AimsThe aim of this study was to determine whether myocardial velocity gradients assessed by M-mode colour Doppler tissue imaging could be of clinical relevance and represent reliable indicators of regional left ventricular function after acute myocardial infarction.
Methods and ResultsAmong 64 consecutive patients with a first acute myocardial infarction, in 50 who had a marked asynergy in the parasternal short-axis view at the mid-papillary muscle level, myocardial velocities and velocity gradients were assessed in the anteroseptum and posterior wall by M-mode Doppler tissue imaging. Similar measurements were obtained in 11 matched healthy volunteers who served as a control group.In patients with anterior myocardial infarction, the peak myocardial velocity gradient in the anteroseptum was significantly lower when compared with controls (mean [SD] 0路0 0路5 vs 1路1 0路7 s 1 during systole, P<0路01; and 0路3 0路6 vs 2路0 0路5 s 1 during diastole, P<0路01). Conversely, the peak systolic myocardial velocity gradient in the posterior wall was significantly higher than in controls (2路6 1路2 vs 1路8 1路2 s 1 , P<0路05).In patients with inferior myocardial infarction, the peak velocity gradient in the posterior wall was significantly lower when compared with healthy subjects (0路9 0路6 vs 1路8 1路2 s 1 during systole and 1路4 1路4 vs 4路9 1路2 s 1 during diastole, both P<0路01). The peak systolic tissue velocity gradient in the anteroseptum was significantly higher than in controls (2路1 1路0 vs 1路1 0路7 s