Shortwave Infrared Imaging with J-Aggregates Stabilized in Hollow Mesoporous Silica Nanoparticles

Chen, Wei; Cheng, Chi‐An; Cosco, Emily D.; Ramakrishnan, Shyam; Lingg, Jakob G. P.; Bruns, Oliver T.; Zink, Jeffrey I.; Sletten, Ellen M.

doi:10.26434/chemrxiv.7503506.v1

Cited by 5 publications

(6 citation statements)

References 8 publications

(10 reference statements)

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“…The NIR‐II QY of FD‐1080 was tested to be 0.31% and could be elevated to 5.94% in FBS buffer. Increasing cyanine NIR‐II dyes have appeared in academic literature through structure redesigning or modifying …”

Section: Synthesis and Chemical Structures Of Nir Dyesmentioning

confidence: 99%

Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

et al. 2019

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Fluorescence bioimaging affords a vital tool for both researchers and surgeons to molecularly target a variety of biological tissues and processes. This review focuses on summarizing organic dyes emitting at a biological transparency window termed the near‐infrared‐II (NIR‐II) window, where minimal light interaction with the surrounding tissues allows photons to travel nearly unperturbed throughout the body. NIR‐II fluorescence imaging overcomes the penetration/contrast bottleneck of imaging in the visible region, making it a remarkable modality for early diagnosis of cancer and highly sensitive tumor surgery. Due to their convenient bioconjugation with peptides/antibodies, NIR‐II molecular dyes are desirable candidates for targeted cancer imaging, significantly overcoming the autofluorescence/scattering issues for deep tissue molecular imaging. To promote the clinical translation of NIR‐II bioimaging, advancements in the high‐performance small molecule–derived probes are critically important. Here, molecules with clinical potential for NIR‐II imaging are discussed, summarizing the synthesis and chemical structures of NIR‐II dyes, chemical and optical properties of NIR‐II dyes, bioconjugation and biological behavior of NIR‐II dyes, whole body imaging with NIR‐II dyes for cancer detection and surgery, as well as NIR‐II fluorescence microscopy imaging. A key perspective on the direction of NIR‐II molecular dyes for cancer imaging and surgery is also discussed.

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Section: Synthesis and Chemical Structures Of Nir Dyesmentioning

confidence: 99%

Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

et al. 2019

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“…Organic NPs doped with small dyes have been reported; these exhibit aggregationinduced emission 25 and J-aggregate formation. 26 These NPs are characterized by high biocompatibility without compromising fluorescence brightness. Conjugated polymer nanoparticles (Pdots) composed of DAD-type conjugated polymers (CPs) have also emerged as new SWIR probes.…”

mentioning

confidence: 99%

Millimeter-Deep Detection of Single Shortwave-Infrared-Emitting Polymer Dots through Turbid Media

Piwoński

Wang

et al. 2020

Nano Lett.

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Fluorescence imaging at longer wavelengths, especially in the shortwave-infrared (SWIR: 1000-1700 nm) region, leads to a substantial decrease in light attenuation, scattering, and background autofluorescence, thereby enabling enhanced penetration into biological tissues. The limited selection of fluorescent probes is a major bottleneck in SWIR fluorescence imaging. Here, we develop SWIR-emitting nanoparticles composed of donor-acceptor-type conjugated polymers.The bright SWIR fluorescence of the polymer dots (primarily attributable to their large absorption cross-section and high fluorescence saturation intensity (as high as 113 kW•cm −2 )) enables the unprecedented detection of single particles as small as 14 nm through millimeter-thick turbid media. Unlike most SWIR-emitting nanomaterials, which have an excited-state lifetime in the range of microseconds to milliseconds, our polymer dots exhibit a subnanosecond excited-state lifetime. These characteristics enable us to demonstrate new time-gated single-particle imaging with a high signal-to-background ratio. These findings expand the range of potential applications of single-particle deep-tissue imaging.

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“…Near-infrared (NIR, 700 -1000 nm) and shortwave infrared (SWIR, 1000 -2000 nm) photoactive materials are highly sought out due to their superior performance in many applications, ranging from deep-tissue imaging, 1 to telecommunications, 2 and LIDAR. 3 Light in the NIR and SWIR transmits over longer distances in the atmosphere and shows less loss for fiber-optic communication due to decreased scatter and absorption in this spectral regime.…”

Section: Introductionmentioning

confidence: 99%

“…𝐻 𝑠 = ∑ 𝐽(𝒏, 𝒎)|𝒏⟩⟨𝒎| 𝒏≠𝒎 + ∑ 𝜖 𝒏 |𝒏⟩⟨𝒏| 𝒏(1) where |𝒏⟩ represents the state where the 𝒏 th molecule is in the excited state while all others in the ground state, 𝐽(𝒏, 𝒎) the excitonic coupling between the two molecules, and 𝜖 𝒏 is the individual site energy.Boundary effects are resolved by imposing periodic boundary conditions, 𝐽(𝒏, 𝒎) = 𝐽(𝒏 − 𝒎). We then diagonalize the Hamiltonian, 𝐻 𝑠 = ∑ 𝜖 𝑘 |𝑘⟩⟨𝑘| 𝑘 , where |𝑘⟩ is the 𝑘 th eigenstate with energy 𝜖 𝑘 .…”

mentioning

confidence: 99%

Design Principles for 2-Dimensional Molecular Aggregates using Kasha’s Model: Tunable Photophysics in Near and Shortwave Infrared

Deshmukh

Koppel²,

Chuang³

et al. 2019

Preprint

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Technologies which utilize near-infrared (700 – 1000 nm) and short-wave infrared (1000 – 2000 nm) electromagnetic radiation have applications in deep-tissue imaging, telecommunications and satellite telemetry due to low scattering and decreased background signal in this spectral region. It is therefore necessary to develop materials that absorb light efficiently beyond 1000 nm. Transition dipole moment coupling (e.g. J-aggregation) allows for redshifted excitonic states and provides a pathway to highly absorptive electronic states in the infrared. We present aggregates of two cyanine dyes whose absorption peaks redshift dramatically upon aggregation in water from ~800 nm to 1000 nm and 1050 nm respectively with sheet-like morphologies and high molar absorptivities (e ~ 105 M-1cm-1). We use Frenkel exciton theory to extend Kasha’s model for J and H aggregation and describe the excitonic states of 2-dimensional aggregates whose slip is controlled by steric hindrance in the assembled structure. A consequence of the increased dimensionality is the phenomenon of an intermediate “I-aggregate”, one which redshifts yet displays spectral signatures of band-edge dark states akin to an H-aggregate. We distinguish between H-, I- and J-aggregates by showing the relative position of the bright (absorptive) state within the density of states using temperature dependent spectroscopy. I-aggregates hold potential for applications as charge injection moieties for semiconductors and donors for energy transfer in NIR and SWIR. Our results can be used to better design chromophores with predictable and tunable aggregation with new photophysical properties.

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Shortwave Infrared Imaging with J-Aggregates Stabilized in Hollow Mesoporous Silica Nanoparticles

Cited by 5 publications

References 8 publications

Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

Millimeter-Deep Detection of Single Shortwave-Infrared-Emitting Polymer Dots through Turbid Media

Design Principles for 2-Dimensional Molecular Aggregates using Kasha’s Model: Tunable Photophysics in Near and Shortwave Infrared

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