Shorter telomere length and DNA hypermethylation in peripheral blood cells of coal workers

Souza, Melissa Rosa de; Kahl, Vivian Francília Silva; Rohr, Paula; Kvitko, Kátia; Cappetta, Mónica; Lopes, Wilner Martinez; Silva, Juliana da

doi:10.1016/j.mrgentox.2018.03.009

Cited by 25 publications

(15 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…De Souza et al . 32 observed DNA instability and an inverse correlation between telomere length and coal exposure in the mine workers but did not detect correlations between aTL and DNA methylation. We also performed correlations examining the relationship of the percentage of global DNA methylation with sex, age and tissues; however, no correlation was found, probably due to our small sample size, despite detecting more global DNA methylation, with no significant difference, in exposed males than in exposed females.…”

Section: Discussioncontrasting

confidence: 57%

“…Telomeres are known to be highly susceptible to oxidative damage and telomere attrition can be accelerated by different environmental factors, such as coal 32 . The ability of ROS to induce 8-oxodG within the GGG triplet found in the telomeric sequence (TTAGGG) is why telomeres are particularly susceptible to oxidative stress-induced damage and chromosome instability, as explained in Coluzzi et al .…”

Section: Discussionmentioning

confidence: 99%

“…The presence of PAH was found in its coal, bottom and fly ash samples 29 , metals were detected in soil samples 30 and Zn, Ni, Cu, Cd, V and Pb were detected in the tissues of the subterranean rodent C. torquatus 23 . In addition, studies with organisms have shown DNA damage in plants ( Baccharis trimera ) 9,31 , snail ( Helix aspersa ) 10 and coal workers’ blood 30,32,33 . To our knowledge, no previous studies have examined the effects of coal and its byproducts on telomere length or DNA global methylation in tuco-tuco.

Figure 1Geographic distribution of C. torquatus , which coincides with the geographic distribution of coal reserves and power plant Candiota (modified from Fernandes et al .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Anthropogenic Effects on Natural Mammalian Populations: Correlation Between Telomere Length and Coal Exposure

Matzenbacher

Silva

Garcia

et al. 2019

Sci Rep

Self Cite

View full text Add to dashboard Cite

The Candiota coal mine in Rio Grande do Sul (RS) is one of the largest in Brazil. Coal is a fossil fuel that causes environmental impacts from its extraction to combustion due to the release of different agents, such as polycyclic aromatic hydrocarbons (PAH) and heavy metals. C tenomys torquatus are herbivorous and subterranean rodents that dig tunnels with their paws and teeth and can be exposed to coal through contaminated food. Exposure to pollutants can cause DNA damage and affect different tissues, inducing alterations in the population structure and genetic diversity. Our study aimed to evaluate the effect of exposure to coal and its derivatives on the C. torquatus population and to examine the relationship of coal exposure with variations in absolute telomere length (aTL), global DNA methylation and genotoxicity. Our study showed an inverse correlation between telomere length and coal exposure in addition to an increase in DNA damage. The results indicate that coal and its byproducts can contribute to the alteration of the C. torquatus population structure, as evidenced by a reduction in the number of adults.

show abstract

Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Figure 1Geographic distribution of C. torquatus , which coincides with the geographic distribution of coal reserves and power plant Candiota (modified from Fernandes et al .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anthropogenic Effects on Natural Mammalian Populations: Correlation Between Telomere Length and Coal Exposure

Matzenbacher

Silva

Garcia

et al. 2019

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…Previous studies have shown that the incidence of hypertension in workers is significantly higher than that in the general population [ 21 , 22 ]. Souza et al demonstrated that occupational coal exposure was associated with shortened RTL [ 16 ], and a case-control study in India found that shorter RTL was associated with essential hypertension [ 23 ]. The telomere length of health care workers (mainly nurses) showed that shift work can lead to shortened telomere length, increased systemic inflammation, and oxidative stress imbalance [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Animal studies and epidemiological surveys found that short telomeres may play an important role in the aetiology of hypertension [ 13 – 15 ]. A recent study found that occupational exposure to coal is positively associated with shorter telomere length [ 16 ], but the relationship between telomere length and high blood pressure among coal miners is unclear. Shanxi Province is rich in coal resources and has a large number of coal miners.…”

Section: Introductionmentioning

confidence: 99%

Relative Telomere Length in Peripheral Blood Cells and Hypertension Risk among Mine Workers: A Case-Control Study in Chinese Coal Miners

Chen

Fan

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

Hypertension is a common chronic disease in middle-aged and elderly people and is an important risk factor for many cardiovascular diseases. Its pathogenesis remains unclear. Epidemiological studies have found that the loss of telomere length in peripheral blood cells can increase the risk of coronary heart disease, myocardial infarction, and other diseases. However, a correlation between loss of telomere length and hypertension has not been established. In this study, we aimed to explore the association between telomere length and the risk of essential hypertension (EH) in Chinese coal miners. A case-control study was performed with 215 EH patients and 222 healthy controls in a large coal mining group located in North China. Face-to-face interviews were conducted by trained staff with the necessary medical knowledge. Relative telomere length (RTL) was measured by a quantitative real-time PCR assay using DNA extracted from peripheral blood. In the control group, the age-adjusted RTL was statistically significantly lower in miners performing hard physical labour compared with nonphysical labour ( P = 0.043 ). A significantly shorter age-adjusted RTL was found in the control group of participants who consumed alcohol regularly compared with those who do not consume alcohol ( P = 0.024 ). Age-adjusted RTL was negatively correlated with body mass index (BMI) and alcohol consumption. Hypertension was also found to be significantly correlated with factors such as age, BMI, alcohol consumption, smoking, and tea consumption. Our results suggest that RTL is associated with hypertension in coal miners.

show abstract

Epigenetic Alterations: The Relation Between Occupational Exposure and Biological Effects in Humans

2019

View full text Add to dashboard Cite

Shorter telomere length and DNA hypermethylation in peripheral blood cells of coal workers

Cited by 25 publications

References 77 publications

Anthropogenic Effects on Natural Mammalian Populations: Correlation Between Telomere Length and Coal Exposure

Anthropogenic Effects on Natural Mammalian Populations: Correlation Between Telomere Length and Coal Exposure

Relative Telomere Length in Peripheral Blood Cells and Hypertension Risk among Mine Workers: A Case-Control Study in Chinese Coal Miners

Epigenetic Alterations: The Relation Between Occupational Exposure and Biological Effects in Humans

Contact Info

Product

Resources

About