Anthropogenic Effects on Natural Mammalian Populations: Correlation Between Telomere Length and Coal Exposure

Matzenbacher, Cristina Araujo; Silva, Juliana da; Garcia, Ana Letícia Hilário; Cappetta, Mónica; Freitas, Thales Renato Ochotorena de

doi:10.1038/s41598-019-42804-8

Cited by 21 publications

(12 citation statements)

References 50 publications

(74 reference statements)

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“…For example, changes in telomere length have been observed in relation to variation in abiotic or biotic conditions, such as the hydric regime (Dupoué et al 2020), temperature (Simide et al 2016, Nowack et al 2019, Burraco et al 2020a), predation risk (Kärkkäinen et al 2019), nutrient quality (Noguera et al 2015) or exposure to parasites (Asghar et al 2015). Anthropogenic disturbances such as the ones linked to urbanisation (Ibáñez‐Álamo et al 2018) or pollution (Matzenbacher et al 2019) have also been associated with shorter telomere lengths. Theoretically, under stressful conditions, faster telomere shortening could be the consequence of the prioritisation of processes ensuring immediate survival rather than telomere maintenance (Casagrande and Hau 2019), a pattern that may be exacerbated at early life stages (Monaghan and Ozanne 2018, Young et al 2018).…”

Section: Environmental Drivers Of Telomere Length Variationmentioning

confidence: 99%

Telomeres in a spatial context: a tool for understanding ageing pattern variation in wild populations

2021

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Ageing refers to the loss of organismal functionality with age, a process that is characterised by decreased reproduction and survival probability. In natural populations, it is expected that environmental conditions influence an individual's ageing trajectory. Understanding the role of environmental heterogeneity on ageing variation could provide critical insights into population resilience and species distribution but remains overlooked. Telomeres, the end cap of chromosomes, are a promising integrative physiological marker of an individual's health and a possible proxy to aid the understanding of variation in ageing trajectories. Here, we review the existing information on telomere length and its dynamics in wild populations distributed across spatial scales. Despite a relative scarcity of information, there is evidence for divergence in telomere length between populations facing contrasting environments. Nonetheless, a higher spatial resolution and temporal replication are needed to fully understand the role that environmental conditions play on telomere length variation. Since most of the existing studies are correlational, future field and laboratory experiments are required. For the first time, we demonstrate the use of population telomere data to predict species habitat suitability through species distribution models (SDMs). This represents a promising new research area in the study of ageing pattern variation in wild populations. Furthermore, the inclusion of telomere data in future physiological SDMs may improve our understanding of species distribution and population resilience. However, the use of telomeres within this context could be limited if no previous knowledge on the relevance of telomeres as markers of health and survival at the species level is available. Finally, we suggest some key practical and theoretical considerations that, ideally, future studies combining biogeographic and telomere data should pay attention.

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Section: Environmental Drivers Of Telomere Length Variationmentioning

confidence: 99%

Telomeres in a spatial context: a tool for understanding ageing pattern variation in wild populations

2021

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“…Telomeres protect the ends of chromosomes to stabilize the nuclear genome with high delity during youth but usually decreasing during aging and with the in uence of environmental agents and diseases 51,52 . The relationship between TL shortening and aging was not observed in this study, although juvenile organisms presented larger telomeres than subadults and adults (shown in Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Telomere length (TL) was quanti ed from the total C. minutus genomic DNA by using a real-time quantitative Polymerase Chain Reaction (qPCR) method following the protocol according to Callicott and Womack 64 , with minor modi cations by Matzenbacher et al 52 . The forward and reverse primer sequences for the telomeric region gene were 5' CGG TTT GTT TGG GTT TGG GTT TGG GTT TGG TTT GGG TT 3' and 5' GGC TTG CCT TAC CCT TAC CCT TAC CCT TAC CCT TAC CCT 3', respectively.…”

Section: Telomere Length Analysis By Qpcrmentioning

confidence: 99%

Using Telomeric Length Measurements and Methylation to Understand The Karyotype Diversification of Ctenomys Minutus (A Small Fossorial Mammals)

Matzenbacher

Silva

Garcia

et al. 2021

Preprint

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The genus Ctenomys has been widely used in karyotype evolution studies due to the variation in their diploid numbers (2n), which range from 2n = 10 to 2n = 70. Ctenomys minutus is characterized by intraspecific variation in diploid number (2n = 42, 46, 48, and 50), which makes it an interesting model to investigate the genomic instability mechanisms that have led to different cytotypes in this species. We aimed to contribute to the knowledge about telomeres’ role in chromosomal instability and global DNA methylation in the genome evolution of C. minutus. This study found that telomere length differs between cytotypes, but only for females (50a<46a,48a,42), although methylation was also higher, no significant difference was shown. It was also shown that young individuals, regardless of cytotype, had the longest telomere and the most methylated DNA, although only the last was statistically significant. Despite this, there is still much to be answered, although new cytotypes seem to have emerged within the distribution of parental cytotypes by the accumulation of different chromosomal rearrangements.

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“…Significant positive correlations in tissue TL have been reported in other vertebrates including macaques ( Macaca fascicularis ; Gardner et al., 2007), dogs ( Canis lupus familaris ; Benetos et al., 2011), zebra finches ( Taeniopygia guttata ; Reichert et al., 2013) and painted dragon lizards ( Ctenophorus pictus ; Rollings et al., 2019). Studies in nonmodel mammalian species found no significant differences between liver, kidney, muscle and skin rTL in collared tuco‐tucos ( Ctenomys torquatus ; Matzenbacher et al., 2019) while significant correlations in rTL were found across liver, brain, ovary and heart in the bank vole ( Myodes glareolus ; Kesäniemi et al., 2019). Furthermore, a study on brown trout ( Salmo trutta ) found fin rTL to correlate significantly with other tissue rTLs, allowing a noninvasive measurement of telomeres (Debes et al., 2016).…”

Section: Introductionmentioning

confidence: 99%

Wing: A suitable nonlethal tissue type for repeatable and rapid telomere length estimates in bats

Power

Bertelsen

et al. 2020

Molecular Ecology Resources

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Telomeres are used increasingly in ecology and evolution as biomarkers for ageing and environmental stress, and are typically measured from DNA extracted from nonlethally sampled blood. However, obtaining blood is not always possible in field conditions and only limited amounts can be taken from small mammals, such as bats, which moreover lack nucleated red blood cells and hence yield relatively low amounts of DNA. As telomere length can vary within species according to age and tissue, it is important to determine which tissues serve best as a representation of the organism as a whole. Here, we investigated whether wing tissue biopsies, a rapid and relatively noninvasive tissue collection method, could serve as a proxy for other tissues when measuring relative telomere length (rTL) in the Egyptian fruit bat (Rousettus aegyptiacus). Telomeres were measured from blood, brain, heart, kidney, liver lung, muscle and wing, and multiple wing biopsies were taken from the same individuals to determine intra‐individual repeatability of rTL measured by using qPCR. Wing rTL correlated with rTL estimates from most tissues apart from blood. Blood rTL was not significantly correlated with rTL from any other tissue. Blood and muscle rTLs were significantly longer compared with other tissues, while lung displayed the shortest rTLs. Individual repeatability of rTL measures from wing tissue was high (>70%). Here we show the relationships between tissue telomere dynamics for the first time in a bat, and our results provide support for the use of wing tissue for rTL measurements.

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Anthropogenic Effects on Natural Mammalian Populations: Correlation Between Telomere Length and Coal Exposure

Cited by 21 publications

References 50 publications

Telomeres in a spatial context: a tool for understanding ageing pattern variation in wild populations

Telomeres in a spatial context: a tool for understanding ageing pattern variation in wild populations

Using Telomeric Length Measurements and Methylation to Understand The Karyotype Diversification of Ctenomys Minutus (A Small Fossorial Mammals)

Wing: A suitable nonlethal tissue type for repeatable and rapid telomere length estimates in bats

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