Short term variability in urinary bisphenol A in Australian children

Heffernan, Amy; Aylward, Lesa L.; Samidurai, A. J.; Davies, Peter S. W.; Toms, Leisa-Maree; Sly, Peter D.; Mueller, Jochen F.

doi:10.1016/j.envint.2014.03.027

Cited by 27 publications

(16 citation statements)

References 44 publications

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“…58,59 A study of Australian children found that a single sample provided moderately reliable assessment of BPA exposure in children, with 68% of individuals correctly classified by a single sample, and 76% correctly classified by 2 samples. 60 Third, we followed recommendations from prior studies to request standardized timing (first morning) of collections, record the time of day and handling of samples, and measure urine dilution using specific gravity. 42,58 …”

Section: Discussionmentioning

confidence: 99%

Changes in urinary bisphenol A concentrations associated with placement of dental composite restorations in children and adolescents

Maserejian¹,

Trachtenberg²,

Wheaton³

et al. 2016

The Journal of the American Dental Association

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Background BisGMA-based dental composites may release bisphenol A (BPA). Our purpose was to assess changes in urinary BPA concentrations over 6-months follow-up in children and adolescents receiving bisGMA-based restorations. Methods We collected urine and interviewed parents/guardians for BPA-related exposure information before and approximately one-day, 14-days, and 6-months post-treatment among 91 participants aged 3–17 years needing composite restorations. We used multivariable linear regression models to test associations between number of surface-restorations placed and changes in urinary BPA concentrations. Results Participants had on average 1.4 (sd=1.0) surfaces filled with composite at the first treatment visit and a cumulative 2.3 (sd=1.6) surfaces filled during the study. Mean change in BPA between pretreatment and next-day was 1.71 ng/mL (sd=9.94) overall and 0.87 (sd=5.98) after excluding one participant with 8 surfaces filled at the visit. Overall, a greater number of composite surface-restorations placed was associated with higher BPA in the next-day sample (posterior-occlusal eβ=1.47, 95% CI 1.18–1.83; P<0.001), but this was attenuated after restricting to the 88 participants with ≤4 fillings (eβ=1.19, 95% CI 0.86, 1.64), and no association was observed using 14-day (eβ=0.94, 95% CI 0.75–1.18) or 6- month (eβ=0.88, 95% CI 0.74–1.04) samples. Conclusions Placement of bisGMA-based restorations in children and adolescents may produce transient increases in urinary BPA concentration, which are no longer detectable approximately 14-days or 6-months post-treatment in urine samples. When few restorations are placed, increases in urinary BPA concentrations may not be detectable owing to high inter-individual variation in BPA exposure. Practical Implications These results suggest that leaching of BPA from newly placed composites ceases being detectable in urine within 2 weeks of restoration placement. The potential human health impact of such short-term exposure remains uncertain.

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Section: Discussionmentioning

confidence: 99%

Changes in urinary bisphenol A concentrations associated with placement of dental composite restorations in children and adolescents

Maserejian¹,

Trachtenberg²,

Wheaton³

et al. 2016

The Journal of the American Dental Association

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“…The limited data available from studies conducted in children indicate that temporal variation in exposure to BPA may be less pronounced in children, including infants, than in adults (ICC of 0.4-0.51 in children compared with 0.1-0.4 in adults) (34,139,140). In adults, it has been recommended that five urine samples should be collected within one discrete sampling period (i.e., 2 days) to classify exposure with acceptable accuracy (139).…”

Section: Minimising Error By Focusing On Questionnaire Validationmentioning

confidence: 99%

“…In adults, it has been recommended that five urine samples should be collected within one discrete sampling period (i.e., 2 days) to classify exposure with acceptable accuracy (139). Based on an ICC of 0.51 in children over a 2-day period, one-spot sample can classify an individual into their correct exposure quartile 68% of the time (34). However, more samples are needed to correctly classify exposure over a longer period of time.…”

Section: Minimising Error By Focusing On Questionnaire Validationmentioning

confidence: 99%

“…In contrast, inter-individual variation was significantly less of a contributor to total variance than intra-individual variation for metabolites of DEHP, BBzP and organophosphates, thereby indicating that more samples are required for accurate exposure classification for these toxicants. However, more studies are required Brought to you by | University of Queensland -UQ Library Authenticated Download Date | 7/21/15 5:17 AM to characterise the ICC for phthalates and insecticides in young children, as well as to characterise the ICC over the time frame, which is typically assessed through the questionnaire-based approach (months to years as opposed to days) (34).…”

Section: Minimising Error By Focusing On Questionnaire Validationmentioning

confidence: 99%

“…These methods might vary according to several factors, like chemical exposure patterns, the exposure period under investigation, toxicokinetics (including the distribution, metabolism and route of elimination from the body), as well as the practicalities of obtaining and analysing biologic media (33). Although biomonitoring may be conducted just once to reliably classify long-term (weeks, months, and years as opposed to days) exposure to persistent pollutants, multiple samples are required to reliably characterise exposure to chemicals that are non-persistent in the human body (e.g., phthalates, BPA, and organophosphate and pyrethroid insecticides), particularly if they have variable exposure patterns (25,34).…”

Section: Pyrethroids and Organophosphatesmentioning

confidence: 99%

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Assessing exposure of young children to common endocrine-disrupting chemicals in the home environment: a review and commentary of the questionnaire-based approach

English

Healy²,

Jagals³

et al. 2015

Reviews on Environmental Health

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AbstractAlthough infants and young children are particularly vulnerable to endocrine disrupting chemical (EDC) exposure, there is an absence of comprehensive exposure data for this age group. As young children spend the majority of their time indoors, improved methods of exposure assessment are needed to characterise the health risks from exposures in the home environment. Biologic assessment, which has been considered the gold standard for exposure assessment in recent years, is difficult to conduct in young children. Questionnaires are an alternative and indirect method of predicting exposure, which may overcome some of the limitations of direct exposure assessment.The feasibility of using a questionnaire-based approach to predict exposure of young children to EDCs in the home has yet to be comprehensively reviewed. Moreover, there is no one questionnaire that has been validated for predicting the exposure of infants to common EDCs in the home.The aim of this review is to discuss the use and validation of the questionnaire-based approach to predict exposure of children to chemicals from three common classes of EDCs in the home, namely, plasticisers, flame retardants, and insecticides. We discuss the strengths and weaknesses of the questionnaire-based approach as well as the important pathways of exposure in the home environment, by which to guide the design and validation of future exposure questionnaires.The findings from our review indicate that the questionnaire-based approach is a valuable tool in the prediction of exposure to persistent organic pollutants, as well as to toxicants that have consistent patterns of exposure. With improvements to the design and validation process, the questionnaire-based approach may also prove to be a reliable instrument in predicting exposure to EDCs with short-half lives, including bisphenol A, phthalates, and pyrethroid and organophosphate insecticides.

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Biomonitoring to Assess Exposures to Mixtures of Environmental Chemicals

Calafat¹

2018

Chemical Mixtures and Combined Chemical and Nonchemical Stressors

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Short term variability in urinary bisphenol A in Australian children

Cited by 27 publications

References 44 publications

Changes in urinary bisphenol A concentrations associated with placement of dental composite restorations in children and adolescents

Changes in urinary bisphenol A concentrations associated with placement of dental composite restorations in children and adolescents

Assessing exposure of young children to common endocrine-disrupting chemicals in the home environment: a review and commentary of the questionnaire-based approach

Biomonitoring to Assess Exposures to Mixtures of Environmental Chemicals

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