Short‐term treatment with ezetimibe, simvastatin or their combination does not alter circulating adiponectin, resistin or leptin levels in healthy men

Abstract

Treatment with ezetimibe, simvastatin or their combination does not alter circulating levels of adiponectin, leptin or resistin in adult healthy men.

Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men

“…Previous kinetic studies have already suggested an increased fractional catabolic rate of LDL apoB-100 following statin therapy, an effect most likely mediated by activation of the LDL receptor gene expression ( 36,37 ). Our data are consistent with results from previous animal and human studies showing an increase in the LDL receptor gene expression following statin therapy (38)(39)(40)(41). Under physiological conditions, HMG-CoAR and LDL receptor mRNAs were closely coregulated, probably because of their common transcriptional activation by SREBP-2 and HNF-4 a ( 42-44 ).…”

Effect of Atorvastatin Versus Rosuvastatin on Levels of Serum Lipids, Inflammatory Markers and Adiponectin in Patients with Hypercholesterolemia

“…Simvastatin was reported failed to affect adiponectin levels or improve insulin sensitivity in subjects with the metabolic syndrome and in healthy men (41,42), while pravastatin exhibits beneficial effects on glucose metabolism especially in the postprandial state associated with increasing plasma adiponectin levels in CAD patients with IGT (43). Atorvastatin has direct effects on the differentiation, apoptosis and endocrine function of adipocytes and can inhibit insulin-induced glucose uptake in differentiated white adipocytes as well as elevate serum adiponectin levels in CAD patients (5,44).…”

Hypolipidemic and pleiotropic effects of a combination of simvastatin and ezetimibe in patients with different types of hyperlipidemia

“…Вместе с тем не обнаружено влияния комбинированной те-рапии на концентрацию лептина, общего и высокомолекулярно-го адипонектина, резистина [34].…”