“…This, however, does not negate the published fi ndings of glucagon on the Srebp-2 pathway, including LDLR ( 46 ), PCSK9 ( 50 ), and cholesterol synthesis ( 29 ). The induction of GRA on GLP-2 is so dramatic that it might have masked the activation on the Srebp-2 pathway caused by blockade of GCGR, inasmuch as intestinal cholesterol absorption and hepatic cholesterol synthesis are reversely affected by each other ( 51,52 ). Another set of observations obtained in the present studies of GRA treatment that we posit to be fruitful for further examinations concerns bile acids.…”