Short‐term safety and tolerability of antihypertensive agents in Korean patients: an observational study

Kim, Young Sik; Park, Hye Soon; Sunwoo, Sung; Byeon, Jai Jun; Song, Yun Mi; Seo, Hong Gwan; Kim, Cheol Hwan; Cheon, Kyeong Soo; Yoo, Sun Mi; Lee, Jung Kwon

doi:10.1002/pds.554

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…The CCB are the only first-line drug class that can be initiated without knowledge and timely follow-up of electrolyte status and kidney function, making them a convenient choice when follow-up scheduling is challenging. The vasodilating effects of CCB can cause adverse effects encompassing dizziness, flushing, headache and tibial edema, which women are more likely to experience [ 8 , 24 ]. Calcium-channel blockers, especially nifedipine, are safe to use during pregnancy.…”

Section: Differences In Effects Of Drugs Used In Hypertensionmentioning

confidence: 99%

Hypertension: sex-related differences in drug treatment, prevalence and blood pressure control in primary care

et al. 2023

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Antihypertensive treatment is equally beneficial for reducing cardiovascular risk in both men and women. Despite this, the drug treatment, prevalence and control of hypertension differ between men and women. Men and women respond differently, particularly with respect to the risk of adverse events, to many antihypertensive drugs. Certain antihypertensive drugs may also be especially beneficial in the setting of certain comorbidities – of both cardiovascular and extracardiac nature – which also differ between men and women. Furthermore, hypertension in pregnancy can pose a considerable therapeutic challenge for women and their physicians in primary care. In addition, data from population-based studies and from real-world data are inconsistent regarding whether men or women attain hypertension-related goals to a higher degree. In population-based studies, women with hypertension have higher rates of treatment and controlled blood pressure than men, whereas real-world, primary-care data instead show better blood pressure control in men. Men and women are also treated with different antihypertensive drugs: women use more thiazide diuretics and men use more angiotensin-enzyme inhibitors and calcium-channel blockers. This narrative review explores these sex-related differences with guidance from current literature. It also features original data from a large, Swedish primary-care register, which showed that blood pressure control was better in women than men until they reached their late sixties, after which the situation was reversed. This age-related decrease in blood pressure control in women was not, however, accompanied by a proportional increase in use of antihypertensive drugs and female sex was a significant predictor of less intensive antihypertensive treatment.

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Section: Differences In Effects Of Drugs Used In Hypertensionmentioning

confidence: 99%

Hypertension: sex-related differences in drug treatment, prevalence and blood pressure control in primary care

et al. 2023

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“…The frequency of cough on ACEI is consistently higher in female patients (Os et al 1994, Visser et al 1995, Kim et al 2000, Morimoto et al 2004, Brugts et al 2014, Sato and Fukuda 2015, Alharbi et al 2017. In a pooled analysis of three RCTs comparing perindopril and placebo in 27,492 patients with vascular diseases, older age (≥65 years) and female gender were positively associated with risk of ACEI-induced cough, with adjusted odds ratio (OR) of 1.53 (95 % CI: 1.35 to 1.73) and 1.92 (95 % CI: 1.68 to 2.18), respectively (Brugts et al 2014).…”

Section: Epidemiology Of Acei-induced Coughmentioning

confidence: 99%

Drug-Induced Cough

Shim

Song

Morice³

2020

Physiol Res

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Since the recognition of angiotensin-converting enzyme inhibitors (ACEIs)-induced cough, drug has been considered as a potential cause of chronic cough. This review presents recent knowledge on drug-induced coughs in patients with chronic cough. The focus is placed on ACEIs, for which there are a multitude of studies documenting their associations with cough. Additional drugs are discussed for which there are reports of cough as a side effect of treatment, and the potential mechanisms of these effects are discussed.

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“…Moreover, earlier studies showed that the incidence of flushing induced by Ca 2+ channel antagonists is high in middle-aged women (3,4). We previously demonstrated that ovariectomy aggravated nifedipine-induced flushing of tail skin in mice and that this event was blocked by estradiol replacement (5).…”

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confidence: 99%

Soybean Isoflavones Eliminate Nifedipine-Induced Flushing of Tail Skin in Ovariectomized Mice

et al. 2004

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Abstract. Hot flushes are one of the most frequent symptoms in menopausal women. We investigated effect of soybean isoflavones (Soyaflavone HG) on nifedipine-induced flushing in ovariectomized mice. Ovariectomy markedly aggravated nifedipine-induced increase in tail skin temperature. Soyaflavone HG (10 mg / kg, p.o., once a day for 5 days) inhibited nifedipineinduced flushing in ovariectomized mice. The inhibitory effect of Soyaflavone HG was significantly reversed by an estrogen-receptor antagonist, ICI 182,780, suggesting that Soyaflavone HG prevents nifedipine-induced flushing partially through estrogen receptors. We presented the experimental evidence suggesting that soybean isoflavones including Soyaflavone HG have the benefits for menopausal hot flushes.

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Short‐term safety and tolerability of antihypertensive agents in Korean patients: an observational study

Abstract: The tolerability of antihypertensive medication was highest in Korean patients treated with ARAs, followed by CCBs, beta-blockers, diuretics, alpha-blockers, and ACEIs. The incidences of adverse reactions were different by sex, age and drug class.

Cited by 7 publications

References 15 publications

Hypertension: sex-related differences in drug treatment, prevalence and blood pressure control in primary care

Hypertension: sex-related differences in drug treatment, prevalence and blood pressure control in primary care

Drug-Induced Cough

Soybean Isoflavones Eliminate Nifedipine-Induced Flushing of Tail Skin in Ovariectomized Mice

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