Short-term progestin treatments prevent estrous induction by a GnRH agonist implant in anestrous bitches

Corrada, Yanina Alejandra; Hermo, Guillermo; Johnson, Cheri A.; Trigg, T. E.; Gobello, Cristina

doi:10.1016/j.theriogenology.2005.04.028

Cited by 24 publications

(27 citation statements)

References 7 publications

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“…Although it was shown that administration of GnRH implants led to induction of estrus in adult animals 6,15 , lower P4 concentrations were determined after estrus induction with deslorelin implants than during spontaneous estrus in bitches 25 . In the present study, two of the treated prepubertal animals showed an increase in serum E2 concentrations from <5 to 37-41 pg/ ml throughout the study period.…”

Section: Discussionmentioning

confidence: 95%

“…In our study, dogs in the control group (G3) did not show an increase in SCI or P4 and E2 concentrations which comparable to anestrus during the observation period. It has already been described that GnRH agonist implants can be easily implanted and removed without local or systemic side effects 5,6,15 . In agreement with these results, in the present study, we did not observe any local inflammatory reactions and pain symptom or systemic side effects after implant insertion.…”

Section: Discussionmentioning

confidence: 99%

“…Bitches exhibit different responses to administration of deslorelin implants depending on the stage of the estrus cycle. A sharp, initial stimulatory gonadotropin response to GnRH agonist treatment known as 'flare-up' occurs after implant insertion which results in an increased release of FSH and LH 15,16 . In dogs, estrus can be induced within 3 to 10 days after treatment 2,6,17 .…”

Section: Introductionmentioning

confidence: 99%

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Clinical and Endocrine Short-Term Effects of GnRH Analogue Deslorelin in Prepubertal Bitches: Does A “Flare-up” Occur?

Kaya¹,

Aslan²,

Kaya³

et al. 2013

Kafkas Univ Vet Fak Derg

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SummaryLong-acting GnRH agonists have been used both in canine estrus induction and prevention. The objective of the study was to investigate the clinical and endocrine short-term effects of a deslorelin implant (4.7 and 9.4 mg) in terms of initial "flare-up" in prepubertal bitches. Fourteen healthy, cross-breed prepubertal female dogs, aged 4 months, were used in the study. An implant containing 9.4 mg (G1, n=5) and 4.7 mg (G2, n=4) deslorelin (Suprelorin®) or a placebo (sodium chloride 0.9%, G3, n=5) was inserted subcutaneously. Estrus was monitored once daily by physical and sexual behavioral changes. Vaginal cytology, serum progesterone (P4) and estradiol 17β (E2) concentrations were monitored weekly for the first five weeks throughout the treatment. None of the bitches in the treatment (G1 and G2) and control (G3) group showed any signs of estrous throughout the study period. No local reactions were observed at the implantation site. Two bitches showed an increase in serum P4 concentrations (>1.0 ng/ml) in G1 (2/5; 40%), however, only one of these two animals (P4=6.37 ng/ml) showed an increase in serum E2 concentrations up to 37 pg/ml. No marked increase in serum P4 and E2 concentrations were observed during the first 13 weeks of treatment in G2. These data demonstrate that in prepubertal bitches, insertion of a deslorelin implant does not cause a "flare-up effect" which commonly occurs in anestrus adult bitches during the first month after implantation. However, further studies are needed to demonstrate that the "flare-up" effect of deslorelin implant in bitches especially during later prepubertal stages. Keywords: Prepubertal bitches, Suprelorin®, Flare-up effect Prepubertal Köpeklerde GnRH Analoğu Deslorelinin Kısa DönemKlinik ve Endokrinolojik Etkileri: "Flare-up" Gözlenir mi? ÖzetUzun etkili GnRH agonistleri köpeklerde hem östrusun uyarılmasında hem de baskılanmasında kullanılmaktadırlar. Bu çalışmada, pubertas öncesi dönemdeki dişi köpeklerde deslorelin implant (4.7 ve 9.4 mg) kullanımının "flare-up" dönemi olarak değerlendirilebilecek klinik ve endokrinolojik kısa dönem etkilerinin varlığı araştırılmıştır. Bu amaçla pubertas öncesi dönemde olduğu belirlenen ortalama 4 aylık yaşta on dört adet sağlıklı melez dişi kopek kullanıldı. Köpeklere deri altı yolla 9.4 mg (G1, n=5) ve 4.7 mg (G2, n=4) deslorelin (Suprelorin®) etken maddesi içeren implantlar ya da plasebo (sodyum klorür %0.9; G3; n=5) uygulandı. Östrus belirtileri günlük olarak fiziksel değişiklikler ve davranış değişiklikleri yönünden takip edildi. Ayrıca çalışma süresince vaginal sitoloji, serum progesteron (P4) ve östradiol 17β (E2) konsantrasyonları haftalık olarak izlendi. Tedavi (G1 ve G2) ve kontrol grubundaki (G3) hayvanların hiçbirinde östrus bulgusu belirlenmedi. İmplantın yerleştirildiği bölgede herhangi bir lokal yan etki gözlenmedi. Grup 1'de iki köpekte (2/5; %40) serum P4 düzeyinde bir artış gözlenirken, bu köpeklerden yalnızca birinde (P4=6,37 ng/ml) serum E2 düzeyinin 37 pg/ml'ye kadar yükseldiği belirlendi. Grup 2'de 13 haftal...

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical and Endocrine Short-Term Effects of GnRH Analogue Deslorelin in Prepubertal Bitches: Does A “Flare-up” Occur?

Kaya¹,

Aslan²,

Kaya³

et al. 2013

Kafkas Univ Vet Fak Derg

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“…2001). More recently, Corrada et al. (2006) treated 10 bitches with a 2.0 mg/kg dosage of MA orally for 8 days starting 4 days prior to administration of a 10‐mg deslorelin implant: only 1/10 bitches showed a post‐oestrous heat response while 4/10 bitches presented a mild vulvar enlargement.…”

Section: Discussionmentioning

confidence: 99%

Clinical Use of Deslorelin for the Control of Reproduction in the Bitch

Romagnoli

Stelletta

Milani

et al. 2009

Reprod Domestic Animals

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This study was conducted to evaluate clinical efficacy of deslorelin for inhibiting reproduction in the bitch. Ten adult healthy bitches or bitches with mammary neoplasia for which owners were requesting suppression of cyclicity without performing gonadectomy were administered a 4.7- or a 9.4-mg deslorelin implant subcutaneously. The first implant of deslorelin was administered in anoestrus (n = 5) or in dioestrus (n = 5). Treatment was repeated every 5 months for as long as necessary based on the clinical situation of the dog and owner's desires. Some of the bitches implanted in anoestrus came in heat within 4-15 days after treatment, while none of the bitches implanted in dioestrus showed heat during treatment. Suppression of reproductive cyclicity was successfully achieved in 6/10 bitches for 1-4 years. No behavioural and local/general side-effects were observed in any of the treated bitches. The 4.7-mg deslorelin implant may work well for suppression of cyclicity provided that it is administered in dioestrus and at intervals of 4.5 months. A 9.4-mg implant may be more suitable for this use although its efficacy may also be shorter than 12 months. Owner compliance is an important limiting factor.

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“…Whereas Wright et al. (2001) noted that megestrol acetate was able to prevent the induced oestrus, Corrada et al. (2006) observed oestrus in three bitches between 26 and 51 days after implantation; the treatment with progestagens simply time‐shifted the induced oestrus.…”

Section: Capitalizing On the Stimulating Effects Of Gnrh Agonists: Oementioning

confidence: 95%

Clinical Use of GnRH Agonists in Canine and Feline Species

Fontaine

Fontbonne

2010

Reprod Domestic Animals

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GnRH (gonadotrophin releasing hormone) is a key hormone of reproductive function in mammals; agonist forms have been largely developed, and data concerning their use in small animal reproduction are now abundant. GnRH agonists act by a two-step mechanism. First, their agonist properties on the pituitary will cause marked LH (luteinizing hormone) and FSH (follicle-stimulating hormone) secretion into the bloodstream, accompanied by an increase in the concentrations of sex steroid hormones. Then, in case of constant administration, GnRH agonists will lead to pituitary desensitization, and FSH and LH levels will collapse. These two effects have been widely documented, and these compounds have many potential benefits in a clinical context, capitalizing both on their stimulating and sterilizing effects.

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Short-term progestin treatments prevent estrous induction by a GnRH agonist implant in anestrous bitches

Cited by 24 publications

References 7 publications

Clinical and Endocrine Short-Term Effects of GnRH Analogue Deslorelin in Prepubertal Bitches: Does A “Flare-up” Occur?

Clinical and Endocrine Short-Term Effects of GnRH Analogue Deslorelin in Prepubertal Bitches: Does A “Flare-up” Occur?

Clinical Use of Deslorelin for the Control of Reproduction in the Bitch

Clinical Use of GnRH Agonists in Canine and Feline Species

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