Clinical Use of Deslorelin for the Control of Reproduction in the Bitch

Abstract

This study was conducted to evaluate clinical efficacy of deslorelin for inhibiting reproduction in the bitch. Ten adult healthy bitches or bitches with mammary neoplasia for which owners were requesting suppression of cyclicity without performing gonadectomy were administered a 4.7- or a 9.4-mg deslorelin implant subcutaneously. The first implant of deslorelin was administered in anoestrus (n = 5) or in dioestrus (n = 5). Treatment was repeated every 5 months for as long as necessary based on the clinical situation of the dog and owner's desires. Some of the bitches implanted in anoestrus came in heat within 4-15 days after treatment, while none of the bitches implanted in dioestrus showed heat during treatment. Suppression of reproductive cyclicity was successfully achieved in 6/10 bitches for 1-4 years. No behavioural and local/general side-effects were observed in any of the treated bitches. The 4.7-mg deslorelin implant may work well for suppression of cyclicity provided that it is administered in dioestrus and at intervals of 4.5 months. A 9.4-mg implant may be more suitable for this use although its efficacy may also be shorter than 12 months. Owner compliance is an important limiting factor.

Deslorelin Implants in Pre‐pubertal Female Dogs: Short‐ and Long‐Term Effects on the Genital Tract

“…The condition of immaturity of the reproductive axis and the pre‐pubertal genital tract could hinder the primary stimulating effects, thereby preventing the appearance of the induced oestrus, as generally observed in the adult bitch (Romagnoli et al. ; Fontaine and Fontbonne ). Our results are in agreement with two previous studies, one based on nafarelin implanted bitches of 4.88 months of age (Rubion et al.…”

“…Using 4.7 mg and 9.4 mg deslorelin implants, administered in dioestrous bitches, the suppression of the reproductive activity was obtained for a period of 1–4 years, using repeated treatments at intervals of 4.5 months and 10 months, respectively (Romagnoli et al. ).…”

Review on Chemical Sterilization of Male Dogs.

“…These methods can postpone puberty in both sexes and can also control the reproductive cycle (Romagnoli et al, 2009;Rojas et al, 2011;Massei and Miller, 2013;Kisiel, 2017). Among GnRH agonists, deslorelin (Suprelorin, Virbac), can suppress reproduction in male dogs for at least a year (Trigg et al, 2001).…”

Manipulation of the oestrous cycle of the bitch—what works… for now

“…These implants are labelled for temporary induction of infertility of the male adult dog and to treat hyperadrenocorticism in ferrets. Nevertheless, agonists of the gonadotropin‐releasing hormone (GnRH) are supposed to be a good option for suppressing the oestrous cycle and have been used in clinical trials (Fontaine & Fontbonne, ; Maenhoudt, Santos, & Fontbonne, ; Romagnoli et al., ; Trigg et al., ). The deslorelin implants (4.7 or 9.4 mg) are designed as a biocompatible lipid matrix (saturated triglyceride) that provides a sustained, gradual and steady release.…”