Short-term pretreatment of naringin isolated from Citrus wilsonii Tanaka attenuates rat myocardial ischemia/reperfusion injury

Liu, Wenting; Cheng, Liping; Li, Xuefei; Zhao, Lili; Hu, Xiaorong; Ma, Zhaocheng

doi:10.1007/s00210-022-02255-x

Cited by 9 publications

(8 citation statements)

References 34 publications

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“…Another relevant aspect in the Citrus fruits industry is represented by the amount of waste [ 28 ]. Indeed, mesocarp and endocarp are by-products, although containing high levels of bioactive constituents, especially Citrus flavonoids, such as naringin [ 29 ]; therefore, there is another field of research that addresses the recovery of waste products.…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective Effects of Grapefruit IntegroPectin Extracted via Hydrodynamic Cavitation from By-Products of Citrus Fruits Industry: Role of Mitochondrial Potassium Channels

Flori

Albanese²,

Calderone

et al. 2022

Foods

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Citrus flavonoids are well-known for their beneficial effects at the cardiovascular and cardio-metabolic level, but often the encouraging in vitro results are not confirmed by in vivo approaches; in addition, the clinical trials are also inconsistent. Their limited bioavailability can be, at least in part, the reason for these discrepancies. Therefore, many efforts have been made towards the improvement of their bioavailability. Hydrodynamic cavitation methods were successfully applied to the extraction of byproducts of the Citrus fruits industry, showing high process yields and affording stable phytocomplexes, known as IntegroPectin, endowed with great amounts of bioactive compounds and high water solubility. The cardioprotective effects of grapefruit IntegroPectin were evaluated by an ex vivo ischemia/reperfusion protocol. Further pharmacological characterization was carried out to assess the involvement of mitochondrial potassium channels. Grapefruit IntegroPectin, where naringin represented 98% of the flavonoids, showed anti-ischemic cardioprotective activity, which was better than pure naringenin (the bioactive aglycone of naringin). On cardiac-isolated mitochondria, this extract confirmed that naringenin/naringin were involved in the activation of mitochondrial potassium channels. The hydrodynamic cavitation-based extraction confirmed a valuable opportunity for the exploitation of Citrus fruits waste, with the end product presenting high levels of Citrus flavonoids and improved bioaccessibility that enhances its nutraceutical and economic value.

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Section: Discussionmentioning

confidence: 99%

Cardioprotective Effects of Grapefruit IntegroPectin Extracted via Hydrodynamic Cavitation from By-Products of Citrus Fruits Industry: Role of Mitochondrial Potassium Channels

Flori

Albanese²,

Calderone

et al. 2022

Foods

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show abstract

“…Therefore, we can discuss, even if not exhaustively, about a putative improvement of the bioavailability. Moreover, we chose to evaluate the anti-ischemic cardioprotection, that has been previously demonstrated for naringin and naringenin [7,12,[24][25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

“…Overall, the experimental results clearly demonstrated the dose-dependent cardioprotective activity of grapefruit IntegroPectin against ischemia/reperfusion injury, showing an efficacy comparable to the purified naringenin but with 10 times lower dose. Moreover, it was reported in the literature that also naringin possesses effective cardioprotection against several types of myocardial insults, yet at higher dose (in the range between 20-100 mg/Kg) compared to that found in grapefruit IntegroPectin [23][24][25][26][27][28].…”

Section: Cardioprotective Effects Of Grapefruit Integropectin In Ex V...mentioning

confidence: 99%

Cardioprotective Effects of Grapefruit Integropectin Extracted via Hydrodynamic Cavitation from By-Products of Citrus Fruits Industry: Role of Mitochondrial Potassium Channels

Flori¹,

Albanese²,

Calderone³

et al. 2022

Preprint

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Citrus flavonoids are well-known for beneficial effects at the cardiovascular and cardio-metabolic level, but often the encouraging in vitro results are not confirmed by in vivo approaches; also clinical trials are inconsistent. The limited bioavailability of them can be, at least in part, the reason of these discrepancies. Therefore many efforts were performed towards the improvement of their bioavailability. Hydrodynamic cavitation methods were successfully applied to the extraction of byproducts of the Citrus fruits industry, showing high process yields and affording stable phytocomplexes, known as IntegroPectin, endowed with great amounts of bioactive compounds and high water solubility. Cardioprotective effects of grapefruit IntegroPectin were evaluated by an ex vivo ischemia/reperfusion protocol. A further pharmacological characterization was carried out to assess the involvement of mitochondrial potassium channels. Grapefruit IntegroPectin, where naringin represented 98% of flavonoids, showed anti-ischemic cardioprotective activity, better than pure naringenin (the bioactive aglycone of naringin). On cardiac isolated mitochondria, this extract confirmed that naringenin/naringin were involved in the activation of mitochondrial potassium channels. The hydrodynamic cavitation-based extraction confirmed a valuable opportunity for the exploitation of Citrus fruits waste, with the end product presenting high levels of Citrus flavonoids and an improved bioaccessibility that enhances its nutraceutical and economic value.

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“…Naringin exerts its total antioxidant capacity in the body through its activity (El-Desoky et al, 2018;Wang et al, 2020). Naringin improved coronary ischemia-reperfusion injury in rats by scavenging free radicals and antioxidant properties (Liu et al, 2022), and it was also protective against ischemia-reperfusion-induced oxidative stress in rat testes (Akondi et al, 2011). Another study revealed the protective effect of naringin against myocardial ischemia-reperfusion injury in rats (Li et al, 2021).…”

Section: Naringin Inhibits the Inflammatory Response Generated During...mentioning

confidence: 99%

Therapeutic potential of naringin in improving the survival rate of skin flap: A review

Wang

et al. 2023

Front. Pharmacol.

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Naringin is the main component of Drynaria. Modern pharmacological studies have shown that naringin has a wide range of pharmacological activities, including antioxidant, anti-inflammatory, anti-apoptotic, anti-ulcer, and anti-osteoporosis effects. Its therapeutic effects have been observed in various clinical models, such as atherosclerosis, cardiovascular diseases, diabetes, neurodegenerative diseases, and rheumatic diseases. This review investigates the pharmacological effects of naringin and the associated mechanisms in improving flap survival. This review will also provide a reference for future rational application of naringin, especially in research to improve flap survival.

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Short-term pretreatment of naringin isolated from Citrus wilsonii Tanaka attenuates rat myocardial ischemia/reperfusion injury

Cited by 9 publications

References 34 publications

Cardioprotective Effects of Grapefruit IntegroPectin Extracted via Hydrodynamic Cavitation from By-Products of Citrus Fruits Industry: Role of Mitochondrial Potassium Channels

Cardioprotective Effects of Grapefruit IntegroPectin Extracted via Hydrodynamic Cavitation from By-Products of Citrus Fruits Industry: Role of Mitochondrial Potassium Channels

Cardioprotective Effects of Grapefruit Integropectin Extracted via Hydrodynamic Cavitation from By-Products of Citrus Fruits Industry: Role of Mitochondrial Potassium Channels

Therapeutic potential of naringin in improving the survival rate of skin flap: A review

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