Therapeutic potential of naringin in improving the survival rate of skin flap: A review

Wang, Yincang; Li, Xiaodong; Lv, Hang; Sun, Lin; Liu, Bo; Zhang, Xiaofeng; Xu, Xilin

doi:10.3389/fphar.2023.1128147

Cited by 4 publications

(2 citation statements)

References 82 publications

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“…Quercetin is accepted as a safe nutritional supplement that can be used as an antimicrobial, antidiabetic, anti-cancer, antioxidant, and anti-inflammatory agent in humans and animals (Azeem et al, 2023). The pharmacological activities of naringin were noted as antioxidant, antiapoptotic, anti-inflammatory, anti-osteoporosis, and antiulcer activities in detailed investigations (Wang et al, 2023). Cinnamic acid and derivatives are used as anticancer, antioxidant, and antimicrobial drugs in in vitro studies (Ruwizhi & Aderibigbe, 2020).…”

Section: Discussionmentioning

confidence: 99%

Gingko biloba L.’nın Fitokimyasal Bileşimi, Antioksidan ve Anti-Kanser Aktiviteleri Üzerine Bir Araştırma

YILMAZ,

DEVECİ,

TEL-ÇAYAN

2023

Comm. J. Biol.

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The study aims to investigate the phytochemical composition, antioxidant potential, and anti-cancer activities of Ginkgo biloba L. leaf methanol extract. In this study, the phytochemical compounds, total phenolic and flavonoid contents of G. biloba leaf methanol extract were investigated. Additionally, antioxidant and anti-cancer activities [against HT-29 (human colon cancer line), HeLa (human cervical cancer line), and HEK-293 (human embryonic kidney cell line)] were assayed. The main phytochemical compounds were identified as gallic (0.94±0.01 mg/g), p-hydroxy benzoic (0.71±0.01 mg/g), and protocatechuic (0.60±0.02 mg/g) acids in G. biloba leaf methanol extract by HPLC. The total phenolic and total flavonoid contents were measured as 71.20±0.42 µg GAE/mg extract and 13.24±0.35 µg QE/mg extract, respectively. The high antioxidant activity was found in ABTS•+ assay (89.04±0.71%) while moderate antioxidant activity was observed in DPPH• (43.31±0.75%), metal chelating (49.04±0.49%), CUPRAC (absorbance: 0.85±0.01), and phosphomolybdenum (absorbance: 1.16±0.02) assays at 400 µg/mL. The IC50 values of G. biloba leaf methanol extract on HT-29, HeLa, and HEK-293 cell lines were recorded as 406.70±1.55, 84.86±0.98, and >800 µg/mL, respectively. The present study features a new addition to the antioxidant and anti-cancer properties of the therapeutically valuable G. biloba with its phytochemical content.

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Section: Discussionmentioning

confidence: 99%

Gingko biloba L.’nın Fitokimyasal Bileşimi, Antioksidan ve Anti-Kanser Aktiviteleri Üzerine Bir Araştırma

YILMAZ,

DEVECİ,

TEL-ÇAYAN

2023

Comm. J. Biol.

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“…Naringin is a disaccharide derivative, derived from Grapefruit and possesses low intrinsic toxicity. Several reviews related to naringin explain the wide therapeutic potential of naringin and its precursor naringenin [1][2][3] . It has been reported to possess a variety of pharmacologic effects, including antibacterial, antiinflammatory, antioxidant, and antitumor properties.…”

Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of solid lipid nanoparticles of naringin to enhance its bioavailability

Vishal Tiwari, Sandeep Jain

2023

tjjpt

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The objective of the present work was to formulate solid lipid nanoparticles loaded with naringin for improving the bioavailability of naringin. The SLNs loaded with naringin were prepared by using different ratio of palmitic and stearic acid as the lipids and Tween 80 as the surfactant. The method nanoprecipitation was used for preparation of the SLNs. The surfactant (Tween 80) helps in steric stabilization of the SLNs. The size range of SLNs obtained on sonicating for 7 was found to be 429 ± 76 nm when stearic acid was used and 365 ± 28 nm when palmitic acid was used for the preparation of SLNs. The zeta potential of all the SLNs ranged from -16 to -27 mV suggesting a stable formulation. The percentage of drug incorporated during nanoparticle preparation was determined by centrifuging the drug loaded nanoparticles at 15,000 rpm for 15 min and separating the supernatant. The highest encapsulation of naringin (71.7 ± 8.6 %) was obtained when the concentration of palmitic acid was 0.14 mmol. The in vitro release of naringin from the SLNs was measured by dialysis method using simulated gastric fluid as the dissolution medium. In vitro release kinetics studies for naringin loaded SLNs exhibited a sustained release pattern. Sustained release was observed over a period of 3 days. The stability of NSLN-7 was studied by storing at 4 ± 1 °C for 30 days. The particle size remained stable at the end of the study with drug entrapment of 71.5 %. This suggests that the SLNs prepared are stable on storage.

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Elucidating the Osteogenic Potential of Naringin and Naringin–Cu(II) Complex: a Comprehensive In Vitro and In Vivo Study

Cui,

Zhou,

2023

Rev. Bras. Farmacogn.

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Therapeutic potential of naringin in improving the survival rate of skin flap: A review

Cited by 4 publications

References 82 publications

Gingko biloba L.’nın Fitokimyasal Bileşimi, Antioksidan ve Anti-Kanser Aktiviteleri Üzerine Bir Araştırma

Gingko biloba L.’nın Fitokimyasal Bileşimi, Antioksidan ve Anti-Kanser Aktiviteleri Üzerine Bir Araştırma

Formulation and evaluation of solid lipid nanoparticles of naringin to enhance its bioavailability

Elucidating the Osteogenic Potential of Naringin and Naringin–Cu(II) Complex: a Comprehensive In Vitro and In Vivo Study

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