1996
DOI: 10.1016/s0014-2999(96)00831-x
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Short-term oral administration of l-arginine reverses defective endothelium-dependent relaxation and cGMP generation in diabetes

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Cited by 58 publications
(38 citation statements)
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“…Similarly, L-arginine treatment in vivo did not affect cholesterol or glucose level nine-treated diabetic rats. Consistent with present findings, studies published recently showed that treatment in hypercholesterolemic rabbits (Bö ger et al, 1995(Bö ger et al, , 1997 or diabetic rats (Pieper et al, 1996), respectively. orally with L-arginine reduced the lipid peroxidation products in patients with diabetes (Lubec et al, 1997a) Several other mechanisms could contribute to the preventive effect of L-arginine on the functional abnorand in the diabetic mice (Lubec et al, , 1997b.…”
Section: Discussionsupporting
confidence: 92%
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“…Similarly, L-arginine treatment in vivo did not affect cholesterol or glucose level nine-treated diabetic rats. Consistent with present findings, studies published recently showed that treatment in hypercholesterolemic rabbits (Bö ger et al, 1995(Bö ger et al, , 1997 or diabetic rats (Pieper et al, 1996), respectively. orally with L-arginine reduced the lipid peroxidation products in patients with diabetes (Lubec et al, 1997a) Several other mechanisms could contribute to the preventive effect of L-arginine on the functional abnorand in the diabetic mice (Lubec et al, , 1997b.…”
Section: Discussionsupporting
confidence: 92%
“…However, our findings show that the in-(EDRF/NO) prevented impairment in vascular reactivcreased responsiveness of aortae from untreated diaity caused by experimental diabetes. Our results are betic rats to NA did not result from an alteration in consistent with those which show that L-arginine supthe sensitivity of tissue to this agonist because the pD 2 plementation in vitro (Pieper and Peltier, 1995; Pieper value was not significantly different from that of the unand Dondlinger, 1997; or in vivo (Pieper et al, 1996) normalizes endothelium-dependent Fig. 2.…”
Section: Discussionsupporting
confidence: 89%
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