Reversal Effects of ? -Arginine Treatment on Blood Pressure and Vascular Responsiveness of Streptozotocin-Diabetic Rats

Özçeli̇kay, A.Tanju; Tay, Aydin; Güner, Şahika; Taşyaran, V; Arı, Nuray; Dinçer, Ü. Deniz; Altan, V.Melih

doi:10.1006/phrs.1999.0576

Cited by 42 publications

(29 citation statements)

References 53 publications

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“…Our functional experiments showed augmented responses to both KCl and PE in the aortae of db/db mice confirming earlier reports of enhanced contractile function in conduit and resistance arteries of db/db mice (Piercy and Taylor 1998;Kanie and Kamata 2000;Pannirselvam et al 2002;Guo et al 2005;Pannirselvam et al 2005;Xie et al 2006;Erdei et al 2007;Zhong et al 2007;Miike et al 2008) as well as in other models of diabetes (Kawasaki 1997;Ozcelikay et al 2000;Okon et al 2003;Matsumoto et al 2007;Shi et al 2007). We and others (Okon et al 2003;Guo et al 2005;Xie et al 2006) have reported that there were no significant changes in the thickness or the cross-sectional areas of the aortae from db/db compared to control mice suggesting that changes in biochemical and/or signaling mechanisms rather than structural changes are responsible for the observed hyper-reactivity.…”

Section: Discussionsupporting

confidence: 91%

Weight and inflammation are the major determinants of vascular dysfunction in the aortae of db/db mice

Sallam

Fisher

Golbidi

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

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The key roles that obesity, hyperglycemia, hyperlipidemia, inflammation, and oxidative stress play in the progression of diabetes vascular complications are well recognized; however, the relative contribution and importance of these individual factors remain uncertain. At 6, 10, or 14 weeks old, blood samples and thoracic aortae were collected from db/db mice and their non-diabetic controls. Plasma samples were analyzed for glucose, 8-isoprostane, CRP, triglycerides, LDL, and HDL as markers of glycemic status, oxidative stress, inflammation, and dyslipidemia, respectively. The responses of the aortic rings to high KCl, phenylephrine (PE), acetylcholine (ACh), and sodium nitroprusside were examined. Statistical methods were used to estimate the strength of the association between plasma variables and vascular functions. Systemic inflammation occurred in db/db mice at an earlier age than did hyperglycemia or oxidative stress. Aortae of db/db showed augmented contractions to PE which were positively correlated with weight, plasma glucose, 8-isoprostane, and CRP. Also, db/db mice showed impaired endothelium-dependent ACh vasorelaxation which was negatively correlated with weight, plasma glucose, and 8-isoprostane. Multivariate analysis and stepwise modeling show that CRP is the major determinant of the contractile responses, while weight and HDL are the major determinants of ACh-induced relaxation. Among the traditional risk factors of obesity, hyperglycemia, oxidative stress, inflammation, and dyslipidemia, our study reveals that weight and inflammation are the major determinants of vascular dysfunction in the aortae of db/db mice. Our findings partially resolve the complexity of diabetes vasculopathies and suggest targeting weight loss and inflammation for effective therapeutic approaches.

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Section: Discussionsupporting

confidence: 91%

Weight and inflammation are the major determinants of vascular dysfunction in the aortae of db/db mice

Sallam

Fisher

Golbidi

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Several prospective studies have indicated that hypertension in diabetic patients takes place at a rate more than twice compared to the normal population. The hypertension is also considered an independent risk factor for cardiovascular mortality in patients with diabetes (Ozcelikay et al, 2000). It has been suggested that alterations in the reactivity of blood vessels to neurotransmitters and circulating hormones are responsible for the cardiovascular complications of diabetes (Christlieb et al, 1976;Ozcelikay et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Oral magnesium administration prevents vascular complications in STZ-diabetic rats

et al. 2005

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“…Several prospective studies have indicated that hypertension in diabetic patients takes place at a rate more than twice of what is compared to the normal population [14]. The hypertension is also considered an independent risk factor for cardiovascular mortality in patients with diabetes [14].…”

Section: Discussionmentioning

confidence: 99%

Vasodilator response to <i>Psidium guajave</i> leaves of mesenteric bed vessels from diabetic and non-diabetic rats

Zaheri¹,

Farshidfar²,

Soltani³

et al. 2014

JDM

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Mortality from cardiovascular abnormalities is almost three times more prevalent in the diabetic population than that in the general population. Psidium guajave has been used traditionally for a long time as a medicinal herb to cure diabetes. Endothelial dependent vasorelaxation effect of Psidium guajave extract on normal aortic rings was observed. This study was designed to investigate the endothelium and nitric oxide roles in PGE-induced vasorelaxation in diabetic rat vessel. Diabetes was induced by a single intraperitoneal injection of streptozotocin. Eight weeks later, superior mesenteric arteries of non-diabetic and diabetic groups were isolated and perfused according to the McGregor method. Prepared vascular beds were constricted with phenylephrine to induce 70% -75% of maximal constriction. Psidium guajave extract at concentrations of 0.1 to 4 mg/100ml added to the medium and perfusion pressure was recorded. Baseline perfusion pressure of diabetic group was significantly higher than non-diabetic rats in both intact and denuded endothelium. Psidium guajave extract caused a significantly dose depended decrease in perfusion pressure in non-diabetic and diabetic groups in both intact and denuded endothelium. In the presence of N (ω)-nitro-L-arginine methyl ester, Psidium guajave ex-tractinduced relaxation in intact mesenteric beds of non-diabetic and diabetic animals was not suppressed. From the results of this study, it may be concluded that vasorelaxatory effect of Psidium guajave extract is not mediated by endothelium and nitric oxide in both diabetic and non-diabetic vessel and supports the use of the plant's leaves as a natural, adjunct phytomedicine in the management of diabetes vessel complications.

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Reversal Effects of ? -Arginine Treatment on Blood Pressure and Vascular Responsiveness of Streptozotocin-Diabetic Rats

Cited by 42 publications

References 53 publications

Weight and inflammation are the major determinants of vascular dysfunction in the aortae of db/db mice

Weight and inflammation are the major determinants of vascular dysfunction in the aortae of db/db mice

Oral magnesium administration prevents vascular complications in STZ-diabetic rats

Vasodilator response to <i>Psidium guajave</i> leaves of mesenteric bed vessels from diabetic and non-diabetic rats

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Reversal Effects of ? -Arginine Treatment on Blood Pressure and Vascular Responsiveness of Streptozotocin-Diabetic Rats

Cited by 42 publications

References 53 publications

Weight and inflammation are the major determinants of vascular dysfunction in the aortae of db/db mice

Weight and inflammation are the major determinants of vascular dysfunction in the aortae of db/db mice

Oral magnesium administration prevents vascular complications in STZ-diabetic rats

Vasodilator response to &lt;i&gt;Psidium guajave&lt;/i&gt; leaves of mesenteric bed vessels from diabetic and non-diabetic rats

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Vasodilator response to <i>Psidium guajave</i> leaves of mesenteric bed vessels from diabetic and non-diabetic rats