Short-Term Night-Shift Working Mimics the Pituitary-Adrenocortical Dysfunction in Chronic Fatigue Syndrome

Leese, Graham; Chattington, Paula; Fraser, William D.; Vora, Jiten; Edwards, R. H. T.; Williams, Gareth

doi:10.1097/00006254-199610000-00017

Cited by 15 publications

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“…It has been shown that sleep disruption and sleep deprivation activate the dominant physiological pattern associated with exposure to stressful circumstances, largely involving the hypothalamicpituitary-adrenal (HPA) stress axis and the sympathetic nervous system (Leese et al, 1996;Spath-Schwalbe et al, 1992). Conversely, administering the stress hormones normally secreted during the physiological activation process (e.g., corticotropic-releasing hormone (CRH) and adrenocorticotro pic hormone (ACTH)) impair sleep quality (Van Reeth et al, 2000).…”

Section: Be the Results Of Living With A Chronic Illness That Is Poorlmentioning

confidence: 99%

Sleep Quality and Psychological Adjustment in Chronic Fatigue Syndrome

et al. 2004

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Section: Be the Results Of Living With A Chronic Illness That Is Poorlmentioning

confidence: 99%

Sleep Quality and Psychological Adjustment in Chronic Fatigue Syndrome

et al. 2004

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“…Leese et al [21] have reported that low cortisol and raised ACTH can be observed after only 5 days disruption of sleep and social routine during shift work. The association between diurnal cortisol change and health transition suggests that the former may be a prognostic marker, particularly in the absence of a correlation with illness duration, but we can not exclude the possibility that these significant correlations were chance findings in a large number of essentially exploratory analyses.…”

Section: Discussionmentioning

confidence: 99%

Diurnal Variation of Adrenocortical Activity in Chronic Fatigue Syndrome

et al. 1998

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Baseline morning and evening serum cortisol and ACTH concentrations, and diurnal changes in hormone levels, were measured in 30 patients with chronic fatigue syndrome (CFS) but without concurrent depressive disorder and a control group of 15 weight-, age- and sex-matched healthy volunteers. Morning cortisol levels were non-significantly lower in CFS patients, while evening levels were non-significantly higher. ACTH concentrations were non-significantly higher in both the morning and evening. The diurnal change in cortisol levels was significantly less in CFS than in controls (p < 0.05). In CFS subjects, evening levels of cortisol correlated significantly with measures of general health and physical functioning, while diurnal change in cortisol was positively correlated with measures of functional improvement over the past year and current social functioning. These results suggest that there is a relationship between adrenocortical function and disability in CFS, but do not reveal the causal connection.

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“…While this seems a robust finding in individuals with established CFS, without prospective studies of individuals at high risk of developing CFS it is difficult to tell whether such changes play a causal role, or are a result of downstream factors such as sleep, deconditioning or circadian rhythm disruption (Spath Schwalde et al 1992;Stupnicki & Obminski, 1992 ;Leese et al 1996).…”

Section: Introductionmentioning

confidence: 99%

Predictors of fatigue following the onset of infectious mononucleosis

et al. 2003

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Background. Infectious mononucleosis (IM) is a risk factor for chronic fatigue. Reduced activity is the most consistent factor found to be associated with poor outcome following the onset of infectious mononucleosis. However, little is known about the biological mechanisms involved in the pathogenesis of chronic fatigue following IM and no study, so far, has examined the relation between certain illness beliefs and poor outcome. This study explored immunological, endocrine, behavioural and cognitive responses to the acute illness and assessed which components of these groups of risk factors predicted a chronic course.

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Short-Term Night-Shift Working Mimics the Pituitary-Adrenocortical Dysfunction in Chronic Fatigue Syndrome

Cited by 15 publications

References 0 publications

Sleep Quality and Psychological Adjustment in Chronic Fatigue Syndrome

Sleep Quality and Psychological Adjustment in Chronic Fatigue Syndrome

Diurnal Variation of Adrenocortical Activity in Chronic Fatigue Syndrome

Predictors of fatigue following the onset of infectious mononucleosis

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