Short term improvement of migraine headaches during ketogenic diet: a prospective observational study in a dietician clinical setting

Lorenzo, Cherubino Di; Sirianni, Giulio; Pierelli, Francesco

doi:10.1186/1129-2377-14-s1-p219

Cited by 6 publications

(8 citation statements)

References 3 publications

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Section: Fasting and Carbohydrate Restricted Dietsmentioning

confidence: 99%

“…Di Lorenzo and colleagues compared ketogenic and low-calorie (1200–1500 kcal/d) diets, in a group of 108 migraineurs [14]. KD was superior to low-calorie diet with a 90% responder rate, while low calorie diet was not effective [14]. Di Lorenzo et al [41] have additionally reported migraine remission following ketosis in an open-label study on 96 migraine suffers.…”

Section: Fasting and Carbohydrate Restricted Dietsmentioning

confidence: 99%

“…Despite several animal studies have been conducted on the effects of ketosis on different aspects of metabolism [52, 53], the exact pathway by which it may affect on CSD, and trigeminal activation has not yet been clarified. However, several mechanisms have been proposed in the literature [14, 52, 53]. According to in vitro research, it is thought that ketosis may attenuate the severity of migraine headache through compensating serotoninergic dysfunction, inhibition of neuronal excitability, decreasing CGRP synthesis and release, and cortical spreading depression (CSD) and by brain mitochondrial function improvement [14, 52, 53].…”

Section: Fasting and Carbohydrate Restricted Dietsmentioning

confidence: 99%

“…However, several mechanisms have been proposed in the literature [14, 52, 53]. According to in vitro research, it is thought that ketosis may attenuate the severity of migraine headache through compensating serotoninergic dysfunction, inhibition of neuronal excitability, decreasing CGRP synthesis and release, and cortical spreading depression (CSD) and by brain mitochondrial function improvement [14, 52, 53]. Moreover, studies on mouse models indicated that ketosis may prevent neurogenic inflammation [19, 54] which is believed to play an important role in migraine pathogenesis [28].…”

Section: Fasting and Carbohydrate Restricted Dietsmentioning

confidence: 99%

“…So far, the effects of different types of diets have been studied in relation to migraine and headache [14–18]. It is speculated that dietary interventions could affect headache/ migraine characteristics through a variety of mechanisms.…”

Section: Introductionmentioning

confidence: 99%

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Association of diet and headache

et al. 2019

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The global prevalence of migraine as a primary headache has been estimated as 14.4% in both sexes. Migraine headache has been ranked as the highest contributor to disability in under 50 years old population in the world. Extensive research has been conducted in order to clarify the pathological mechanisms of migraine. Although uncertainties remains, it has been indicated that vascular dysfunction, cortical spreading depression (CSD), activation of the trigeminovascular pathway, pro-inflammatory and oxidative state may play a putative role in migraine pain generation. Knowledge about pathophysiological mechanisms of migraine should be integrated into a multimodal treatment approach to increase quality of life in patients. With respect to this, within the integrative health studies growing interest pertains to dietary interventions. Although the number of studies concerning effects of diet on headache/migraine is not yet very large, the current article will review the available evidence in this area. All publications on headache/migraine and dietary interventions up to May 2019 were included in the present review through a PubMed/MEDLINE and ScienceDirect database search. According to the current findings, Ketogenic diet and modified Atkins diet are thought to play a role in neuroprotection, improving mitochondrial function and energy metabolism, compensating serotoninergic dysfunction, decreasing calcitonin gene-related peptide (CGRP) level and suppressing neuro-inflammation. It can also be speculated that prescription of low glycemic diet may be promising in headache/migraine control through attenuating the inflammatory state. Moreover, obesity and headaches including migraine could be attributed to each other through mechanisms like inflammation, and irregular hypothalamic function. Thereby, applying dietary strategies for weight loss may also ameliorate headache/migraine. Another important dietary intervention that might be effective in headache/migraine improvement is related to balance between the intake of essential fatty acids, omega-6 and omega-3 which also affect inflammatory responses, platelet function and regulation of vascular tone. Regarding elimination diets, it appears that targeted these diets in migraine patients with food sensitivities could be effective in headache/migraine prevention. Taken together, dietary approaches that could be considered as effective strategies in headache/migraine prophylaxis include weight loss diets in obese headache patients, ketogenic and low-calorie diets, reducing omega-6 and increasing omega-3 fatty acid intakes.

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Section: Fasting and Carbohydrate Restricted Dietsmentioning

confidence: 99%

Section: Fasting and Carbohydrate Restricted Dietsmentioning

confidence: 99%

Section: Fasting and Carbohydrate Restricted Dietsmentioning

confidence: 99%

Section: Fasting and Carbohydrate Restricted Dietsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of diet and headache

et al. 2019

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Obesity, Weight Loss, and Nutrition in Headache Disorders

Armand

2021

Integrative Headache Medicine

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Diet and nutraceutical interventions for headache management: A review of the evidence

Orr

2016

Cephalalgia

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Background The use of complementary and alternative medicines (CAM) is common among patients with primary headaches. In parallel, CAM research is growing. Diet interventions comprise another category of non-pharmacologic treatment for primary headache that is of increasing clinical and research interest. Methods A literature search was carried out to identify studies on the efficacy of diet and nutraceutical interviews for primary headache in the pediatric and adult populations. MEDLINE, Embase and EBM Reviews-Cochrane Central Register of Controlled Trials were searched to identify studies. Results There is a growing body of literature on the potential use of CAM and diet interventions for primary headache disorders. This review identified literature on the use of a variety of diet and nutraceutical interventions for headache. Most of the studies assessed the efficacy of these interventions for migraine, though some explored their role in tension-type headache and cluster headache. The quality of the evidence in this area is generally poor. Conclusions CAM is becoming more commonplace in the headache world. Several interventions show promise, but caution needs to be exercised in using these agents given limited safety and efficacy data. In addition, interest in exploring diet interventions in the treatment of primary headaches is emerging. Further research into the efficacy of nutraceutical and diet interventions is warranted.

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Short term improvement of migraine headaches during ketogenic diet: a prospective observational study in a dietician clinical setting

Cited by 6 publications

References 3 publications

Association of diet and headache

Association of diet and headache

Obesity, Weight Loss, and Nutrition in Headache Disorders

Diet and nutraceutical interventions for headache management: A review of the evidence

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