Short-term glucocorticoids for flares in people with rheumatoid arthritis receiving disease-modifying anti-rheumatic drugs (DMARDs)

Glennon, Vanessa; Whittle, Samuel L; Hill, Catherine; Johnston, Renea V; Avery, Jodie; Grobler, Liesl; McKenzie, Bayden J; Cyril, Sheila; Pardo, Jordi Pardo; Buchbinder, Rachelle

doi:10.1002/14651858.cd014898

Cited by 4 publications

(3 citation statements)

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“…This is the case of the transcriptional antagonism between NFκB and glucocorticoid receptors (GR). Glucocorticoids trigger immune suppression, partly by decreasing the expression of inflammatory genes that are under the transcriptional control of NFκB [155]. It has been demonstrated that CBP functions in this case as an integrator of the physical interaction between NFκB-p65 and GR at the level of the Rel Homology Domain (RHD), and not as a limiting co-factor for the transcriptional NFκB program [156].…”

Section: The Nrf2-nfκb Crosstalkmentioning

confidence: 99%

Pros and cons of NRF2 activation as adjunctive therapy in rheumatoid arthritis

Manda

Milanesi

Genç

et al. 2022

Free Radical Biology and Medicine

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Section: The Nrf2-nfκb Crosstalkmentioning

confidence: 99%

Pros and cons of NRF2 activation as adjunctive therapy in rheumatoid arthritis

Manda

Milanesi

Genç

et al. 2022

Free Radical Biology and Medicine

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“…Nonsteroidal anti-inflammatory drugs (NSAIDs), such as naproxen and ibuprofen, were also used as treatment methods for RA, but they have the least effects on preventing or reducing the damage caused to the joints. Therefore, these drugs no longer remain the preferred treatment according to the guidelines recently presented . Citronellol (Ct), a monoterpene alcohol, is commonly present in the essential oils of different kinds of aromatic plants, for example, Cymbopogon citratus, Lippia alba, and C.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, these drugs no longer remain the preferred treatment according to the guidelines recently presented. 15 Citronellol (Ct), a monoterpene alcohol, is commonly present in the essential oils of different kinds of aromatic plants, for example, Cymbopogon citratus , Lippia alba , and C. winterianus . 16 Many studies reported pharmacological functions of Ct such as antibacterial, antifungal, antihypertensive, vasodilation, antioxidant, and anti-inflammatory.…”

Section: Introductionmentioning

confidence: 99%

Mechanistic Evaluation of Antiarthritic Effects of Citronellol in CFA-Induced Arthritic Rats

Dar,

Mobashar,

Shabbir

et al. 2023

ACS Omega

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Rheumatoid arthritis (RA) is an autoimmune disease characterized by systemic inflammation, joint tissue damage, pain, and synovitis. It leads to deformity of joints, disability, and even premature death. Markers of inflammation are highly expressed in synovium fluid and serum of arthritic patients and play an important role in the pathophysiology of RA. These transcription factors promote the fabrication of type I interferons and inflammatory cytokines. In RA, degradation of synovial cartilage and bone results from stimulation of proinflammatory cytokines. Citronellol (Ct), a monoterpene alcohol, is found in citrus fruits and essential oils of many aromatic plants. It possesses numerous pharmacological properties such as antioxidant activity and potential antinociceptive and anti-inflammatory effects. Keeping in view the significant anti-inflammatory role of Ct, a trial of 28 days was conducted. Ct was administered orally at three different doses (25, 50, and 100) mg/kg in Freund's adjuvant-induced arthritic rats, and the results were compared with piroxicam, chosen as the standard drug. The antiarthritic activity of the compound was evaluated through measurements of arthritic scoring and plethysmometry before and after treatment. The blood biochemical and hematological parameters and histopathological analyses were performed. Additionally, qPCR was conducted to analyze the mRNA expression levels of TNF-α, IL-1β, NF-κB, MMP3, IL-6, and IL-4 in the blood. ELISA was performed to evaluate the levels of PGE2. The results demonstrated that Ct showed significant results at all doses, but the highest dose proved to be most significant in terms of decreasing arthritic scoring and paw edema, indicating the antiarthritic potential of Ct. Furthermore, the compound was found to downregulate all the proinflammatory cytokines (TNF-α, IL-1β, NF-κB, MMP3, and IL-6) and upregulate the anti-inflammatory cytokine (IL-4). The levels of PGE2 were also reduced which further supported the antiarthritic effects of Ct and validated it as a potential antiarthritic candidate.

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