Pros and cons of NRF2 activation as adjunctive therapy in rheumatoid arthritis

Manda, Gina; Milanesi, Elena; Genç, Şermin; Niculite, Cristina Mariana; Neagoe, Ionela Victoria; Tastan, Bora; Dragnea, Elena Mihaela; Cuadrado, Antonio

doi:10.1016/j.freeradbiomed.2022.08.012

Cited by 8 publications

(5 citation statements)

References 302 publications

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“…This enzyme confers protection against oxidative, inflammatory, and hypoxic stress in joint tissues by regulating synovial cell activation and metabolism. 60,61 In the present study, in agreement with previous reports of our research group, 8,9,22 Nrf2 and HO-1 expressions were decreased in the arthritis group. On the contrary, dietary OLA was able to recover Nrf2 and HO-1 expressions.…”

Section: Discussionsupporting

confidence: 93%

Dietary oleacein, a secoiridoid from extra virgin olive oil, prevents collagen-induced arthritis in mice

Rosillo,

Villegas,

Vázquez-Román

et al. 2024

Food Funct.

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Section: Discussionsupporting

confidence: 93%

Dietary oleacein, a secoiridoid from extra virgin olive oil, prevents collagen-induced arthritis in mice

Rosillo,

Villegas,

Vázquez-Román

et al. 2024

Food Funct.

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“…Nrf2 is a redox regulator, which plays a protective role by exerting anti-inflammatory and antioxidant effects ( 168 ). Significantly, the protective role of Nrf2 has been linked to relieving severe symptoms in RA via detoxification, regulation of redox balance, and metabolism ( 34 , 169 ).…”

Section: Other Tfsmentioning

confidence: 99%

Targeting transcription factors for therapeutic benefit in rheumatoid arthritis

et al. 2023

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Rheumatoid arthritis (RA) is a destructive inflammatory autoimmune disease that causes pain and disability. Many of the currently available drugs for treating RA patients are aimed at halting the progression of the disease and alleviating inflammation. Further, some of these treatment options have drawbacks, including disease recurrence and adverse effects due to long-term use. These inefficiencies have created a need for a different approach to treating RA. Recently, the focus has shifted to direct targeting of transcription factors (TFs), as they play a vital role in the pathogenesis of RA, activating key cytokines, chemokines, adhesion molecules, and enzymes. In light of this, synthetic drugs and natural compounds are being explored to target key TFs or their signaling pathways in RA. This review discusses the role of four key TFs in inflammation, namely NF-κB, STATs, AP-1 and IRFs, and their potential for being targeted to treat RA.

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“…Therefore, the inflammatory response against parasitic microorganisms, which is accompanied by the generation of ROS, is one of the main pillars of innate immunity. Uncontrolled inflammation, by creating an imbalance between oxidants and antioxidants, could cause much damage to the host [ 1 , 2 ]. Oxidative stress elicits apoptosis and oxidative stress-induced diseases, such as neurodegenerative and cardiovascular diseases, accelerated aging, secondary infections, and malignancies.…”

Section: Introductionmentioning

confidence: 99%

The role of Nrf2 signaling in parasitic diseases and its therapeutic potential

Vatankhah,

Panahizadeh,

Safari

et al. 2024

Heliyon

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Pros and cons of NRF2 activation as adjunctive therapy in rheumatoid arthritis

Cited by 8 publications

References 302 publications

Dietary oleacein, a secoiridoid from extra virgin olive oil, prevents collagen-induced arthritis in mice

Dietary oleacein, a secoiridoid from extra virgin olive oil, prevents collagen-induced arthritis in mice

Targeting transcription factors for therapeutic benefit in rheumatoid arthritis

The role of Nrf2 signaling in parasitic diseases and its therapeutic potential

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