Short-term exposure to the peroxisome proliferators, perfluorooctanoic acid and perfluorodecanoic acid, causes significant increase of 8-hydroxydeoxyguanosine in liver DNA of rats

Perfluorooctanoic acid (PFOA) but not perfluorooctane sulfonate (PFOS) showed DNA damage in comet assay on Paramecium caudatum

“…According to Abdellatif et al (2003Abdellatif et al ( -2004, dietary exposure to 0.02% PFOA for 5 and 9 weeks does not affect 8-OH-dG in the liver of Wistar rats. The difference in the 8-OH-dG induction between the reports of Takagi et al (1991) and Abdellatif et al (2003Abdellatif et al ( -2004 may be attributable to administration schedule and/or to the rat strain.…”

“…We detected increases in both ROS in the DCFH-DA assay and DNA damages in the comet assay; however we detect neither the DNA strand brakes nor increase in 8-OH-dG level. Takagi et al (1991) reported that single intraperitoneal injection of 100 mg/kg PFOA induced 8-OH-dG in the liver of F344 rats. According to Abdellatif et al (2003Abdellatif et al ( -2004, dietary exposure to 0.02% PFOA for 5 and 9 weeks does not affect 8-OH-dG in the liver of Wistar rats.…”

“…Takagi et al (1991) reported PFOA-induced 8-OHdG in rat liver. According to Abdellatif et al (2003Abdellatif et al ( -2004, PFOA does not affect rat liver 8-OH-dG significantly.…”

Differential toxicity between perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA)

“…In rodents, the PXR receptor can interact with PPARα in the coordination of hepatocyte proliferation, but there are differences in the amino acid composition of the ligand binding domain of the mouse receptor and the human receptor. A significant increase in 8-OH-dG liver levels, a biomarker for oxidative stress, was observed at ≥ 10 mg PFOA/kg in the liver but not the kidney of Fischer 344 male rats by Takagi et al (1991). Work with HepG2 cells by Hu and Hu (2009) suggested that PFOA could induce apoptosis by overwhelming the homeostasis of antioxidative systems, increasing reactive oxygen species (ROS), impacting mitochondria, and changing expression of apoptosis gene regulators.…”

Per- and polyfluorinated substances in the Nordic Countries

“…Animal experimental studies Several studies have been published on the potential biological responses of exposure to PFBA in experimental animals Das et al, 2008;Permadi et al, 1992;Takagi et al, 1991) and in studies conducted in primary rat hepatocytes (Intrasuksri and Feller, 1991;Intrasuksri et al, 1998;Vanden Heuvel et al, 1991). In general, PFBA was effective in inducing peroxisome proliferation in these rodent studies but the in vivo potency was lower than for PFOA at same doses.…”