Short-term exposure to dim light at night disrupts rhythmic behaviors and causes neurodegeneration in fly models of tauopathy and Alzheimer's disease

Kim, Mari; Manivannan, S.; Cho, Yun Ho; Kim, Gye Hyeong; Lee, Eunil; Park, Joong Jean

doi:10.1016/j.bbrc.2017.12.021

Cited by 34 publications

(23 citation statements)

References 30 publications

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“…A decrease of brain activation while working is also reported after sleeping under 10 lx light [13]. ALAN also affects learning and memory impairment [77] with increase of neurodegenerataion in Alzheimer's drosophila model [78].…”

Section: Alan Exposure In the General Populationmentioning

confidence: 92%

Light and Life at Night as Circadian Rhythm Disruptors

Lee

Kim

2019

Chronobiol Med

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The axial rotation of the Earth, together with the light of the sun, generates 24-hour cycles of day and night, and this light-dark cycle is the basis of 24-hour circadian rhythms. Living organisms have their own endogenous circadian rhythms, also with a duration of approximately 24 hours, driven by environmental factors, especially light and darkness [1]. And it is widely known that circadian rhythms of mammals are regulated by an internal biological clock located in the suprachiasmatic nuclei (SCN) situated directly above the optic chiasm [2]. Maintaining the biological clock is crucial for coordinated function throughout the human body because this near-24-hour oscillations are found in essentially every physiological process in the human brain and body [3,4]. The period, phase and amplitude of circadian rhythms can be affected by circadian gene variants, light exposure, social cues, meal times and work schedules [5-8]. Light is the most effective

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Section: Alan Exposure In the General Populationmentioning

confidence: 92%

Light and Life at Night as Circadian Rhythm Disruptors

Lee

Kim

2019

Chronobiol Med

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“…Several processes such as oxidative stress, inflammation, dopamine synthesis, and cellular metabolism are under the control of the circadian clock, and may contribute to neurodegeneration (Logan and McClung, 2019). Although most studies have suggested that circadian disorder is a symptom of neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease, some evidence indicates that circadian dysregulation induced by night illumination can cause enhanced incidence of tau deposition and neurodegeneration (Kim et al, 2018). Furthermore, increased risk of Alzheimer’s disease and Parkinson’s disease has been associated with the incidence of single-nucleotide polymorphisms in CLOCK and BMAL1 , and in BMAL1 and PER1 , respectively (Logan and McClung, 2019).…”

Section: Circadian Rhythm Disorder and Diseasesmentioning

confidence: 99%

New Insights Into the Circadian Rhythm and Its Related Diseases

et al. 2019

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Circadian rhythms (CR) are a series of endogenous autonomous oscillators generated by the molecular circadian clock which acting on coordinating internal time with the external environment in a 24-h daily cycle. The circadian clock system is a major regulatory factor for nearly all physiological activities and its disorder has severe consequences on human health. CR disruption is a common issue in modern society, and researches about people with jet lag or shift works have revealed that CR disruption can cause cognitive impairment, psychiatric illness, metabolic syndrome, dysplasia, and cancer. In this review, we summarized the synchronizers and the synchronization methods used in experimental research, and introduced CR monitoring and detection methods. Moreover, we evaluated conventional CR databases, and analyzed experiments that characterized the underlying causes of CR disorder. Finally, we further discussed the latest developments in understanding of CR disruption, and how it may be relevant to health and disease. Briefly, this review aimed to synthesize previous studies to aid in future studies of CR and CR-related diseases.

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“…As with PD, cause and effect remain unclear. While much of the data focuses on circadian dysregulation as a symptom of AD, there is some evidence from fly models that circadian disruption through nocturnal light exposure results in increased tau deposition and neurodegeneration (Kim et al., ), so circadian dysregulation may serve to speed the progression of disease in vulnerable individuals.…”

Section: Future Of Circadian Rhythm Disordersmentioning

confidence: 99%

Circadian disruption and human health: A bidirectional relationship

Abbott

Malkani

Zee

2019

Eur J of Neuroscience

102

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Circadian rhythm disorders have been classically associated with disorders of abnormal timing of the sleep–wake cycle, however circadian dysfunction can play a role in a wide range of pathology, ranging from the increased risk for cardiometabolic disease and malignancy in shift workers, prompting the need for a new field focused on the larger concept of circadian medicine. The relationship between circadian disruption and human health is bidirectional, with changes in circadian amplitude often preceding the classical symptoms of neurodegenerative disorders. As our understanding of the importance of circadian dysfunction in disease grows, we need to develop better clinical techniques for identifying circadian rhythms and also develop circadian based strategies for disease management. Overall this review highlights the need to bring the concept of time to all aspects of medicine, emphasizing circadian medicine as a prime example of both personalized and precision medicine.

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Short-term exposure to dim light at night disrupts rhythmic behaviors and causes neurodegeneration in fly models of tauopathy and Alzheimer's disease

Cited by 34 publications

References 30 publications

Light and Life at Night as Circadian Rhythm Disruptors

Light and Life at Night as Circadian Rhythm Disruptors

New Insights Into the Circadian Rhythm and Its Related Diseases

Circadian disruption and human health: A bidirectional relationship

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