Short-term exercise combined with Acipimox administration induces an increase in plasma ACTH and its subsequent fall in the recovery phase in bulimic women

Smitka, Kvido; Papežová, Hana; Vondra, K; Hill, Martin; Hainer, Vojtěch; Nedvı́dková, J

doi:10.1016/j.regpep.2012.12.010

Cited by 4 publications

(5 citation statements)

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“…Also lower dosages of leptin could potentially ameliorate hyperactivity, depression, the metabolic profile, and reproductive function in acutely ill AN patients after weight regain [257]. At present, leptin, ghrelin, GOAT, NPY, tumour necrosis factor-alpha (TNF- α ) downregulating agents such as dexamethasone and potentially Aci, or their synthetic analogs [6, 7, 13, 56, 256–258] as well as selective serotonin reuptake inhibitors (SSRI) and serotonin NE reuptake inhibitors (SNRI) may be useful agents for the modulation of food intake, especially serotonin-dopamine antagonists (e.g., Olanzapine) which have been found to be effective for treating AN [256, 259]. In the treatment of eating disorders, modified blood-brain barrier in AN and BN is a therapeutic target for delivery of any therapeutics to the central nervous system [103, 104, 260] (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, because of reduced volume of subcutaneous abdominal AT, less leptin is secreted into plasma. It has been shown that SNS can exert tonic inhibitory action on leptin secretion and that adrenergic regulation may contribute to rapid decrease both of plasma leptin and insulin levels during exercise in AN and BN patients [6, 7, 30]. …”

Section: An Overview Of Hunger-satiety Signals and Autoantibodies mentioning

confidence: 99%

“…It has been reported that BN patients with a significantly higher number of daily binge/vomiting episodes hyposecrete leptin in spite of no changes in their BMI [6, 7, 238, 239]. Interestingly, we observed opposite changes in plasma leptin and ghrelin levels during the exercise with Aci administration and in the postexercise recovering phase in both BN patients and healthy women [6, 7, 12, 13, 240]. Plasma soluble OB-R was unaffected in BN patients when compared with the controls [234].…”

Section: An Overview Of Hunger-satiety Signals and Autoantibodies mentioning

confidence: 99%

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The Role of “Mixed” Orexigenic and Anorexigenic Signals and Autoantibodies Reacting with Appetite-Regulating Neuropeptides and Peptides of the Adipose Tissue-Gut-Brain Axis: Relevance to Food Intake and Nutritional Status in Patients with Anorexia Nervosa and Bulimia Nervosa

Smitka

Papežová

Vondra

et al. 2013

International Journal of Endocrinology

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Eating disorders such as anorexia (AN) and bulimia nervosa (BN) are characterized by abnormal eating behavior. The essential aspect of AN is that the individual refuses to maintain a minimal normal body weight. The main features of BN are binge eating and inappropriate compensatory methods to prevent weight gain. The gut-brain-adipose tissue (AT) peptides and neutralizing autoantibodies play an important role in the regulation of eating behavior and growth hormone release. The mechanisms for controlling food intake involve an interplay between gut, brain, and AT. Parasympathetic, sympathetic, and serotoninergic systems are required for communication between brain satiety centre, gut, and AT. These neuronal circuits include neuropeptides ghrelin, neuropeptide Y (NPY), peptide YY (PYY), cholecystokinin (CCK), leptin, putative anorexigen obestatin, monoamines dopamine, norepinephrine (NE), serotonin, and neutralizing autoantibodies. This extensive and detailed report reviews data that demonstrate that hunger-satiety signals play an important role in the pathogenesis of eating disorders. Neuroendocrine dysregulations of the AT-gut-brain axis peptides and neutralizing autoantibodies may result in AN and BN. The circulating autoantibodies can be purified and used as pharmacological tools in AN and BN. Further research is required to investigate the orexigenic/anorexigenic synthetic analogs and monoclonal antibodies for potential treatment of eating disorders in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Section: An Overview Of Hunger-satiety Signals and Autoantibodies mentioning

confidence: 99%

Section: An Overview Of Hunger-satiety Signals and Autoantibodies mentioning

confidence: 99%

See 1 more Smart Citation

The Role of “Mixed” Orexigenic and Anorexigenic Signals and Autoantibodies Reacting with Appetite-Regulating Neuropeptides and Peptides of the Adipose Tissue-Gut-Brain Axis: Relevance to Food Intake and Nutritional Status in Patients with Anorexia Nervosa and Bulimia Nervosa

Smitka

Papežová

Vondra

et al. 2013

International Journal of Endocrinology

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“…Hypoleptinaemia is actually accompanied by a decrease in basal energy expenditure in women with amenorrhea. Indeed, in anorexia nervosa (AN) and bulimia nervosa (BN) patients, plasma leptin levels were found to be lower than in normal weight controls (Nedvídková et al, 2000;Dostálová et al, 2007;Smitka et al, 2011Smitka et al, , 2013a. However, realimentation leads to an increase in plasma leptin levels in AN and BN patients.…”

Section: Leptinmentioning

confidence: 99%

Adipose Tissue as an Endocrine Organ: An Update on Pro-inflammatory and Anti-inflammatory Microenvironment

2015

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Adipose tissue is recognized as an active endocrine organ that produces a number of endocrine substances referred to as "adipokines" including leptin, adiponectin, adipolin, visfatin, omentin, tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), resistin, pigment epithelium-derived factor (PEDF), and progranulin (PGRN) which play an important role in the food intake regulation and significantly influence insulin sensitivity and in some cases directly affect insulin resistance in skeletal muscle, liver, and adipose tissue. The review summarizes current knowledge about adipose tissue-derived hormones and their influence on energy homeostasis regulation. The possible therapeutic potential of these adipokines in the treatment of insulin resistance, endothelial dysfunction, a pro-inflammatory response, obesity, eating disorders, progression of atherosclerosis, type 1 diabetes, and type 2 diabetes is discussed.

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“…These “mixed” signals may initiate or exacerbate episodes of binge-purging and post-binge eating cycles in BN (4). In our previous studies, we documented different responses of growth hormone (GH), ghrelin, NPY, and ACTH to treatment with the anti-hyperlipidemic drug Acipimox (OLB) in BN, and we confirmed that OLB with exercise indicates GH inhibition of ghrelin (4, 9–11). Thus, OLB administration has been shown as an enhancer of GH, ACTH, and leptin release.…”

Section: Introductionmentioning

confidence: 54%

Acipimox Administration With Exercise Induces a Co-feedback Action of the GH, PP, and PYY on Ghrelin Associated With a Reduction of Peripheral Lipolysis in Bulimic and Healthy-Weight Czech Women: A Randomized Study

et al. 2019

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Objective: Anti-lipolytic drugs and exercise are enhancers of growth hormone (GH) secretion. Decreased circulating free fatty acids (FFA) have been proposed to exert ghrelin-GH feedback loop after administration of an anti-lipolytic longer-acting analog of nicotinic acid, Acipimox (OLB, 5-Methylpyrazine-2-carboxylic acid 4-oxide, molecular weight of 154.1 Da). OLB administration strongly suppresses plasma FFA during exercise. Neuroendocrine perturbations of the adipose tissue (AT), gut, and brain peptides may be involved in the etiopathogenesis of eating disorders including bulimia nervosa (BN) and anorexia nervosa. BN is characterized by binge eating, self-induced vomiting or excessive exercise.Approach: To test the hypothesis that treatment with OLB together with exercise vs. exercise alone would induce feedback action of GH, pancreatic polypeptide (PP), peptide tyrosine tyrosine (PYY), and leptin on ghrelin in Czech women with BN and in healthy-weight Czech women (HW). The lipolysis rate (as glycerol release) in subcutaneous abdominal AT was assessed with microdialysis. At an academic medical center, 12 BN and 12 HW (the control group) were randomized to OLB 500 mg 1 h before a single exercise bout (45 min, 2 W/kg of lean body mass [LBM]) once a week vs. identical placebo over a total of 2 weeks. Blood plasma concentrations of GH, PP, PYY, leptin, ghrelin, FFA, glycerol, and concentrations of AT interstitial glycerol were estimated during the test by RIA utilizing 125I-labeled tracer, the electrochemiluminescence technique (ECLIA) or colorimetric kits.Results: OLB administration together with short-term exercise significantly increased plasma GH (P < 0.0001), PP (P < 0.0001), PYY, and leptin concentrations and significantly decreased plasma ghrelin (P < 0.01) concentrations in both groups, whereas short-term exercise with placebo resulted in plasma ghrelin (P < 0.05) decrease exclusively in BN. OLB administration together with short-term exercise significantly lowered local subcutaneous abdominal AT interstitial glycerol (P < 0.0001) to a greater extent in BN.Conclusion: OLB-induced suppression of plasma ghrelin concentrations together with short-term exercise and after the post-exercise recovering phase suggests a potential negative co-feedback of GH, PP, PYY, and leptin on ghrelin secretion to a greater extent in BN. Simultaneously, the exercise-induced elevation in AT interstitial glycerol leading to a higher inhibition of peripheral lipolysis by OLB in BN.Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT03338387

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Short-term exercise combined with Acipimox administration induces an increase in plasma ACTH and its subsequent fall in the recovery phase in bulimic women

Cited by 4 publications

References 44 publications

The Role of “Mixed” Orexigenic and Anorexigenic Signals and Autoantibodies Reacting with Appetite-Regulating Neuropeptides and Peptides of the Adipose Tissue-Gut-Brain Axis: Relevance to Food Intake and Nutritional Status in Patients with Anorexia Nervosa and Bulimia Nervosa

The Role of “Mixed” Orexigenic and Anorexigenic Signals and Autoantibodies Reacting with Appetite-Regulating Neuropeptides and Peptides of the Adipose Tissue-Gut-Brain Axis: Relevance to Food Intake and Nutritional Status in Patients with Anorexia Nervosa and Bulimia Nervosa

Adipose Tissue as an Endocrine Organ: An Update on Pro-inflammatory and Anti-inflammatory Microenvironment

Acipimox Administration With Exercise Induces a Co-feedback Action of the GH, PP, and PYY on Ghrelin Associated With a Reduction of Peripheral Lipolysis in Bulimic and Healthy-Weight Czech Women: A Randomized Study

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