Short-Term Evaluation of Guided Bone Reconstruction with Titanium Mesh Membranes and CGF Membranes in Immediate Implantation of Anterior Maxillary Tooth

Abstract

Purpose. The aim of the present prospective study was to evaluate the effect of titanium mesh and concentrated growth factor (CGF) membranes in reconstructing severe labial bone defects during immediate implantation of anterior maxillary tooth. Methods. Patients with severe defects presenting on the anterior labial bone plate of maxillary were enrolled in this study. During immediate implantation, the titanium mesh was used to maintain the space of bone graft, collagen membrane, and xenograft bone that were used to guide bone regeneration (GBR). Cone beam computed tomography (CBCT) was used to measure the height and the labial bone thickness around the implant at the time of the second stage surgery, 6 months, 1 year, and 2 years after restoration. The pink esthetic score (PES) was used to evaluate the esthetic outcomes after restoration. Results. 18 patients were enrolled in this study. The survival rate of implants was 100%, and no complication was observed, except for 1 case of titanium mesh exposure which did not affect osteogenesis. In the second stage of surgery, the labial bone was completely reconstructed, and the top of the implant was covered with a small amount of new bone. The thickness of the labial bone was 3.01 mm (±0.23), 2.96 mm (±0.21), 2.93 mm (±0.19), and 2.92 mm (±0.16) at the time of the second stage surgery, 6 months, 1 year, and 2 years after restoration, respectively. The height of the marginal bone around implants was above the top of implant at the time of the second stage surgery and then reduced 0.72 mm (±0.07), 0.91 mm (±0.08), and 0.90 mm (±0.07) at the time point of 6 months, 1 year, and 2 years after restoration, respectively. The changes of bone thickness and height were statistically significant within one year, but stable after one year. The PES values showed the same tendency. Conclusions. With the limitation of the present prospective study, the combination of titanium mesh and CGF membrane could provide space maintenance for bone augmentation of alveolar bone defects and improve the bone regeneration in patients with severe labial bone defect when immediate implant of anterior maxillary.

“Sticky Bone” Preparation Device: A Pilot Study on the Release of Cytokines and Growth Factors

“…Interesting outcomes have been reported for CGF in bone tissue regeneration, such as inducing active new bone formation in the maxillary sinus without postoperative complications [23,24], and contributing to new bone formation in large diaphyseal bone defects by the Masquelet technique [25]. It also has been proposed in modified protocols combining its fibrin matrix with denatured albumin [7], titanium mesh membranes [26], bone morphogenetic protein-2 (BMP-2) [27], or particulate materials such as in sticky bone [10].…”

Clinical applications of concentrated growth factors membrane for sealing the socket in alveolar ridge preservation: a randomized controlled trial

“…As an autologous blood extract, CGF has the advantages of low cost, convenient collection, and mild postoperative response. In recent years, CGFs membranes were used in guided bone regeneration to promote soft tissue healing [ 26 ]. In addition, the high concentration of anti-infection factors in CGF reduced the likelihood of postoperative infections [ 27 ].…”

Bone regeneration using titanium plate stabilization for the treatment of peri‐implant bone defects: A retrospective radiologic pilot study

“…After healing, BBT‐0 and BBT‐2 decreased by 1.05–1.68 mm and 0.71–1.70 mm, respectively, 4,7 and the crestal bone level at the buccal was found to be 0.35–0.77 mm apical to the implant platform 13,15 . However, greater ridge volume has been obtained using adjunctive titanium mesh or TR‐PTFE, with BBL at reentry ranging from −0.22 to 1.44 mm coronal to the implant platform 13,15,39,40 ; BBT‐0 and BBT‐2 at reentry of 2.0–3.01 mm 13,39–41 and 2.74–2.86 mm, 39,40 respectively; and losses in BBT‐0 and BBT‐2 from initial surgery to reentry of 0.14–0.30 mm 13,40 and 0.29 mm, 40 respectively.…”