Clinical applications of concentrated growth factors membrane for sealing the socket in alveolar ridge preservation: a randomized controlled trial

Liu, Yumeng; Li, Xiaoming; Jiang, Changwei; Guo, Huajun; Luo, Guisheng; Huang, Yangyang; Yuan, Changyong

doi:10.1186/s40729-022-00448-w

Cited by 7 publications

(6 citation statements)

References 32 publications

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“…Five studies [ 45 , 51 , 58 , 60 , 61 ] evaluated the efficacy of CGF in ARP procedures (Table 3 ). Follow-up periods ranged from 3 months to 8 months.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…The other two studies [ 60 , 61 ] compared the effects of collagen membranes with CGF membrane as a barrier membrane. Liu et al [ 61 ] reported that the application of CGF membrane had a faster rate of soft tissue healing and similar bone formation compared with Bio-Gide® collagen membranes. Furthermore, the result of study by Lin et al [ 60 ] suggested that bone graft + CGF + CGF membrane effectively reduced the resorption of alveolar ridge and resulted in more newly formed bone than bone graft + collagen membrane.…”

Section: Resultsmentioning

confidence: 99%

“…In this systematic review, there were not enough RCTs to quantitatively compare the effects of CGF membranes with collagen membranes. Compared to collagen membrane, the application of CGF membrane provided a better soft tissue healing rate [ 61 ]. However, when the principle of guided tissue or bone regeneration (GTR or GBR) [ 44 , 83 ] was applied to the treatment of periodontal intrabony defects [ 84 ], peri-implantitis [ 44 , 85 ], or horizontal ridge augmentation [ 53 ], using a barrier membrane over the grafting material, CGF membrane did not provide superior clinical outcomes compared to collagen membranes.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of concentrated growth factor (CGF) in the surgical treatment of oral diseases: a systematic review and meta-analysis

Chen,

Cheng,

Cai

et al. 2023

BMC Oral Health

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Background Concentrated growth factor (CGF), a new autologous platelet concentrate, has been widely investigated to the adjunctive treatment of oral diseases. This study aims to evaluate the efficacy of CGF in the surgical treatment of oral diseases. Methods MEDLINE, Web of Science, Scopus, Cochrane, and EMBASE databases were searched up to July 2023. Only randomized clinical trials were included. The methodologic quality was evaluated by the Cochrane Risk of Bias Tool. RevMan 5.4 software was used for data analysis. Results In the treatment of periodontal intrabony defects, bone graft combined with CGF was significantly superior to bone graft (P < 0.01), with mean intrabony defect depth reduction of 1.41 mm and mean clinical attachment level gain of 0.55 mm. In the regenerative surgery of furcation defects, the effect of CGF group was significantly better than control group (P < 0.0001), with mean probing depth reduction of 0.99 mm, vertical bone gain of 0.25 mm, and horizontal bone gain of 0.34 mm. CGF combined with coronally advanced flap (CAF) was more effective than CAF alone (mean keratinized tissue width increase of 0.41 mm, mean gingival thickness increase of 0.26 mm, P < 0.00001), but less effective than connective tissue graft (CTG) combined with CAF (mean root coverage difference of -15.1%, mean gingival thickness difference of -0.5 mm, P < 0.0001). In the alveolar ridge preservation, additional use of CGF reduced horizontal bone resorption by 1.41 mm and buccal vertical bone resorption by 1.01 mm compared to control group (P < 0.0001). The VAS score of CGF group was significantly lower than that of the control group at the 1st and 7th day after oral surgery (P < 0.0001). Conclusions CGF can exert a positive adjunctive effect for the regenerative surgery of periodontal intrabony defects, furcation defects, and alveolar ridge preservation procedure. CGF combined with CAF has a better therapeutic effect on gingival recession compared to CAF alone, although it is not as effective as CTG combined with CAF. CGF could promote postoperative healing and pain relief in oral surgery within a week. There is currently not enough evidence to support the clinical benefits of CGF in other oral surgeries.

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“…Five studies [ 45 , 51 , 58 , 60 , 61 ] evaluated the efficacy of CGF in ARP procedures (Table 3 ). Follow-up periods ranged from 3 months to 8 months.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy of concentrated growth factor (CGF) in the surgical treatment of oral diseases: a systematic review and meta-analysis

Chen,

Cheng,

Cai

et al. 2023

BMC Oral Health

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“…[ 1 ] Following the removal of all teeth in an adult, alveolar process atrophy and hard-tissue reduction occur. [ 2 3 ] The bundle bone at the site loses function and eventually disappears. [ 4 5 6 ] Most bone loss occurs in the horizontal dimension, primarily on the alveolar ridge’s facial aspect.…”

Section: Introductionmentioning

confidence: 99%

Soft-Tissue Augmentation in Periodontally Compromised Patients during Immediate Placement and Immediate Loading Dental Implant Surgery - A Retrospective Study

Lazarov

2023

Annals of Maxillofacial Surgery

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Introduction The purpose of this article is to describe a soft-tissue augmentation procedure for multiple tooth extraction sites during immediate placement and immediate loading (IPIL) dental implant surgery in periodontally compromised patients and to present follow-up results of its effectiveness. Methods A retrospective study was conducted on data from patients who underwent IPIL dental implant surgery between 2018 and 2021 at an oral implant centre in Bulgaria. Based on inclusion and exclusion criteria, 103 patients were included, 53 of whom had pre-operative indications for connective tissue grafts (CTGs) and 50 of whom did not. The post-operative incidence of gum recession was evaluated in the two patient groups. Results The majority of the 53 patients (56.60%) had six, seven or eight tooth sites grafted. A significant proportion (87%) needed CTGs at the canine teeth (13 and 23), P < 0.001. The post-operative data showed a low incidence of gum recessions in both the patient groups, with a lower rate in the CTG group at tooth no: 13 (2.20% vs. 18%, P = 0.016) and in the total sum of 10 tooth sites with CTGs (P = 0.001). A reduction in gum problems and increased satisfaction with gum health and aesthetics were reported by 100% of the CTG patients. Discussion Soft-tissue augmentation at multiple tooth extraction sites during IPIL dental implant treatment may benefit periodontally compromised patients through an improved prosthesis–tissue interface in the aesthetic area and a reduction in gum infections, swelling, bleeding and pain.

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Can concentrated growth factor prevent postoperative complications of impacted third molar surgery? A split-mouth randomized double-blind trial

Huang,

2024

Clin Oral Invest

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Clinical applications of concentrated growth factors membrane for sealing the socket in alveolar ridge preservation: a randomized controlled trial

Cited by 7 publications

References 32 publications

Efficacy of concentrated growth factor (CGF) in the surgical treatment of oral diseases: a systematic review and meta-analysis

Efficacy of concentrated growth factor (CGF) in the surgical treatment of oral diseases: a systematic review and meta-analysis

Soft-Tissue Augmentation in Periodontally Compromised Patients during Immediate Placement and Immediate Loading Dental Implant Surgery - A Retrospective Study

Can concentrated growth factor prevent postoperative complications of impacted third molar surgery? A split-mouth randomized double-blind trial

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