Short-term effects of aluminum and selenium on redox status in mice brain and blood

Stanevičienė, Inga; Ivanov, Leonid; Kuršvietienė, Lolita; Vieželienė, Dalė

doi:10.5414/tex01472

Cited by 5 publications

(4 citation statements)

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“…Pb exposure also induced lipid peroxidation in the blood, kidney, and liver [ 66 ] with the increase due to a decrease in glutathione and other cellular antioxidant defenses [ 67 ]. Al exposure also induced lipid peroxidation in a variety of organs [ 68 ]. In this case, it is believed that Al acts as a prooxidant and facilitates oxidative stress through superoxide- and endogenous Fe-associated mechanisms [ 69 , 70 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Indicators of Oxidative Damage from Embedded Metal Fragments in a Rat Model

Kalinich

Vergara

Hoffman

2022

Oxidative Medicine and Cellular Longevity

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Injuries suffered in armed conflicts often result in embedded metal fragments. Standard surgical guidance recommends leaving embedded fragments in place except under certain circumstances in an attempt to avoid the potential morbidity that extensive surgery often brings. However, technological advances in weapon systems and insurgent use of improvised explosive devices now mean that practically any metal can be found in these types of wounds. Unfortunately, in many cases, the long-term toxicological properties of embedded metals are not known, further complicating treatment decisions. Because of concerns over embedded metal fragment injuries, the U.S. Departments of Defense and Veterans’ Affairs developed a list of “metals of concern” for these types of injuries. In this study, we selected eight of these metals including tungsten, nickel, cobalt, iron, copper, aluminum, lead, and depleted uranium to investigate the long-term health effects using a rodent model developed in our Institute to study embedded fragment injuries. In this report, we show that metals surgically implanted into the gastrocnemius muscle of laboratory rats to simulate a shrapnel wound induce a variety of cytokines including IFN-γ, IL-4, IL-5, IL-6, IL-10, and IL-13. TNF-α and KC/GRO were not affected, and IL-1β was below the limit of detection. Serum levels of C-reactive protein were also affected, increasing with some metals and decreasing with others. The TBARS assay, an assessment of lipid peroxidation, demonstrated that implanted aluminum and lead increased markers of lipid peroxidation in serum. Taken together, the results suggest that serum cytokine levels, as well as other indicators of oxidative damage, may prove useful in identifying potential adverse health effects of embedded metals.

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Section: Discussionmentioning

confidence: 99%

Serum Indicators of Oxidative Damage from Embedded Metal Fragments in a Rat Model

Kalinich

Vergara

Hoffman

2022

Oxidative Medicine and Cellular Longevity

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“…Cannabis sativa L. produces multiple chemical compounds of different biogenetic classes [ 15 ], and many studies have demonstrated the antioxidant activity of Cannabis in vitro [ 19 , 22 ]. The phenolic compounds are mainly responsible for the antioxidant activity, while hemp seeds due to their active compounds, have health benefits such as lowering the cholesterol level in the blood or alleviating constipation and are also useful in the treatment of cardiovascular diseases [ 11 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…Hempseed has been shown to be a useful antioxidant [ 18 ]. Our recent study showed the ability of Cannabis sativa L. herb extracts to demonstrate antioxidant activity in vitro [ 19 ]. Still, the results of antioxidant properties in vitro and in vivo are not always the same.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Cannabis sativa L. Extract on Oxidative Stress Markers In Vivo

Kubilienė

Mickutė

Baranauskaitė

et al. 2021

Life

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In recent decades, a lot of attention has been paid to Cannabis sativa L. due to its useful applications, including in fibers, oil, food for humans and animals, and therapeutics. The present study aimed to determine antioxidant activity of cannabinoids in Cannabis sativa L. in vivo, evaluating the possible antioxidative effect of Cannabis sativa L. extract (CE) on malondialdehyde (MDA) and glutathione (GSH) concentrations as well as on catalase (CAT) activity in BALB/c mice. In total, 40 mice were divided into five equal groups: the aluminum group (7.5 mg AlCl3/kg/d (0.15 LD50), the saline group, the 10% ethanol group (an appropriate amount of the solution for mouse weight), the CE group (1.6 mg CE/g/day), and the aluminum-CE group (7.5 mg AlCl3 plus 1.6 mg CE/g/day). The results of the study showed that CE significantly decreased (by 26.81%, p < 0.05) the concentration of GSH in blood of the mice and the concentration of MDA in the brain (by 82.12%) and liver (by 53.5%) of the mice compared to the respective concentrations in the AlCl3 group. CE significantly (p < 0.05) increased CAT activity in the brain (by 64.79%) and liver (by 72.37%) of the mice after the AlCl3-induced prooxidant effect. The results showed the antioxidant activity of cannabidiolic acid (CBDA) in vitro. The findings in vivo indicate that Cannabis sativa L. is a good source of natural antioxidants and can be used in the management of oxidative stress.

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“…In our previous experimental studies, we evaluated the effect of acute exposure to Al on oxidative stress and the capacity of the antioxidant system in mouse organs by using the Al intoxication model that involved the injection of AlCl 3 solution into the abdominal cavity of the mouse [25][26][27][28]. However, the obtained results encouraged us to select a different route of administration of Al: the oral route.…”

Section: Introductionmentioning

confidence: 99%

Effects of Long-Term Supplementation with Aluminum or Selenium on the Activities of Antioxidant Enzymes in Mouse Brain and Liver

et al. 2020

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The aim of this study was to investigate the effects of aluminum (Al) or selenium (Se) on the “primary” antioxidant defense system enzymes (superoxide dismutase, catalase, and glutathione reductase) in cells of mouse brain and liver after long-term (8-week) exposure to drinking water supplemented with AlCl3 (50 mg or 100 mg Al/L in drinking water) or Na2SeO3 (0.2 mg or 0.4 mg Se/L in drinking water). Results have shown that a high dose of Se increased the activities of superoxide dismutase and catalase in mouse brain and liver. Exposure to a low dose of Se resulted in an increase in catalase activity in mouse brain, but did not show any statistically significant changes in superoxide dismutase activity in both organs. Meanwhile, the administration of both doses of Al caused no changes in activities of these enzymes in mouse brain and liver. The greatest sensitivity to the effect of Al or Se was exhibited by glutathione reductase. Exposure to both doses of Al or Se resulted in statistically significant increase in glutathione reductase activity in both brain and liver. It was concluded that 8-week exposure to Se caused a statistically significant increase in superoxide dismutase, catalase and glutathione reductase activities in mouse brain and/or liver, however, these changes were dependent on the used dose. The exposure to both Al doses caused a statistically significant increase only in glutathione reductase activity of both organs.

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Short-term effects of aluminum and selenium on redox status in mice brain and blood

Cited by 5 publications

References 0 publications

Serum Indicators of Oxidative Damage from Embedded Metal Fragments in a Rat Model

Serum Indicators of Oxidative Damage from Embedded Metal Fragments in a Rat Model

The Effects of Cannabis sativa L. Extract on Oxidative Stress Markers In Vivo

Effects of Long-Term Supplementation with Aluminum or Selenium on the Activities of Antioxidant Enzymes in Mouse Brain and Liver

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