Short-Term Effect of High-Dose Vitamin D on the Level of Interleukin 10 in Patients with Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Ashtari, Fereshteh; Toghianifar, Nafiseh; Zarkesh-Esfahani, Hamid; Mansourian, Marjan

doi:10.1159/000439278

Cited by 51 publications

(41 citation statements)

References 24 publications

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“…In addition, the UVB-dependent generation of bioactive Vitamin D and its relevance for MS have been studied over decades, since high serum levels of Vitamin D correlate with low incidence and disease activity, thus representing both a mechanistic explanation for the latitude gradient as well as a druggable target for MS 27,28 . However, even though recent clinical studies showed a decrease in inflammatory cytokine serum levels of Vitamin D treated patients 29 , an intervention study using Vitamin D2 failed to show effectiveness of the treatment, but, in contrast, demonstrated increased disease scores in the treatment group after the study period 30 . Thus, changes in Vitamin D levels might represent an epiphenomenon of sun exposure rather than an explanation for the latitude gradient or a druggable target for therapeutic intervention in MS.…”

Section: Geographic Factors and Sun Exposurementioning

confidence: 94%

Environmental control of autoimmune inflammation in the central nervous system

Rothhammer

Quintana

2016

Current Opinion in Immunology

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Summary Multiple Sclerosis (MS) is a chronic autoimmune inflammatory demyelinating disorder of the central nervous system (CNS), which causes severe disability and requires extensive medical attention and treatment. While the infiltration of pathogenic immune cells into the CNS leads to the formation of inflammatory lesions in its initial relapsing-remitting stage, late stages of MS are characterized by progressive neuronal loss and demyelination even without continued interaction with the peripheral immune compartment. Several genetic and environmental factors modulate and influence these processes on multiple levels. Genetic variants confer a predisposition for the development of MS, but are not accessible to therapeutic intervention as of today. However, migration studies suggest that environmental factors influence disease development, activity and progression. This article reviews mechanisms of disease pathogenesis in MS and their modulation by environmental factors such as geographical localization, the gut microbiome and the diet.

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Section: Geographic Factors and Sun Exposurementioning

confidence: 94%

Environmental control of autoimmune inflammation in the central nervous system

Rothhammer

Quintana

2016

Current Opinion in Immunology

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“…At the end of the study, the researchers found that IL-10 levels increased significantly after taking the high-dose vitamin D3 for three months. They concluded that high doses of vitamin D could be valuable in promoting an anti-inflammatory state in RRMS patients (Ashtari et al, 2015). Fitzgerald et al (2015) studied the relationship between 25-hydroxyvitamin D (25[OH] D) levels and disease course in patients with RRMS treated with interferon beta-1b.…”

Section: Resultsmentioning

confidence: 99%

High-Dose Vitamin D3 Intake Is Associated with Decreased Symptoms of Multiple Sclerosis

Steinwart¹,

Duriancik²

2018

American Journal of Immunology

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Multiple sclerosis (MS) is one of the most widespread disabling autoimmune neurological conditions of adults between the ages of 20 and 40 globally. Medical researchers do not completely understand the possible causes of MS, nor have they determined the rate of progression. A limited number of clinical trials conducted in recent years have explored the link between vitamin D deficiency and MS with vitamin D supplementation as a possible element in the treatment of this disease. The primary goal of this review was to synthesize the evidence regarding the link between vitamin D3 levels and the symptoms of MS. A PubMed search was conducted using keywords Vitamin D, multiple sclerosis, MS, RRMS, prevention, treatment and cause. 1153 articles and sources were found using the key phrase "multiple sclerosis and vitamin D," but these were narrowed to 11 based on publication dates between 2013 and 2018, clinical trials were included, while reviews were excluded and the relevance of the goals to this review. Study designs included experimental clinical trials where pretest/posttest data were presented. Articles were excluded if they were not peer reviewed or only described the method and were awaiting results. Although not all studies found uniform results, the majority of the evidence suggests that high intakes of vitamin D may be associated with improved quality of life through the reduction of certain symptoms of MS. This was especially evident in patients who started the studies with a vitamin D deficiency. It may be too early to prescribe an increase in daily supplementation of vitamin D with the hope of reducing the development of or in the treatment of MS, but recent studies indicate that high doses of vitamin D could decrease the probability of some symptoms of the disease and possibly give favorable results in treatment. Further studies are needed before specific recommendations can be made.

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“…Daily vitamin D supplementation for 35 days increased IL‐10 in vitamin D insufficient subjects (serum 25(OH)D < 29 ng/mL) (Barker et al, ). Furthermore, three month supplementation with 50000 IU vitamin D for 3 month increased IL‐10 in multiple sclerosis (Ashtari, Toghianifar, Zarkesh‐Esfahani, & Mansourian, ). IL‐10 is an anti‐inflammatory cytokine that can reduce the oxidative stress and amplify insulin sensitivity (Zhang et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…increased IL-10 in multiple sclerosis (Ashtari, Toghianifar, Zarkesh-Esfahani, & Mansourian, 2015). IL-10 is an anti-inflammatory cytokine that can reduce the oxidative stress and amplify insulin sensitivity (Zhang et al, 2017).…”

Section: Ta B L E 3 Effects Of Vitamin D On Omentin Vaspin An Inflammentioning

confidence: 99%

The effects of supplementation with vitamin D on inflammatory biomarkers, omentin, and vaspin in women with type 2 diabetes: A randomized double‐blind placebo‐controlled clinical trial

Fazelian

Paknahad

Khajehali³

et al. 2018

J Food Biochem

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Type 2 diabetes (T2DM) is a global problem that increases the risk of inflammation and hormonal dysfunction. The purpose of this study was to determine the effect of vitamin D on inflammatory biomarkers, omentin, and vaspin in diabetic women with anxiety. In this study, 51 women with T2DM were allocated to receive one oral pearl of 50,000 IU vitamin D3 (26) or a placebo (25) fortnightly for 16 weeks. Anthropometric indices, dietary intake, high sensitivity C‐reactive protein (hs‐CRP), Interleukin 10 (IL‐10), vaspin, and omentin were measured at the baseline and after 16‐weeks supplementation. Serum hs‐ CRP was reduced (p = 0.01) and IL‐10 concentrations was increased (p = 0.04) in intervention group. Vitamin D marginally increased serum levels of omentin (p = 0.06), however, vaspin did not change post‐intervention. According to subgroup analysis, omentin levels increased significantly in participants with lower baseline serum vitamin D (p = 0.008). Vitamin D can improve anti‐inflammatory biomarkers in diabetic patients. Practical applications Diabetes is prevalent in the world. Inflammation in diabetic patients causes other chronic diseases such as cardio vascular disease. Adipose tissue contributes to the regulation of metabolism and insulin sensitivity. Two hormones secreted from adipose tissue that play an important role in insulin function and anti‐inflammatory activity. Vitamin D, can improve insulin sensitivity and inflammation via effects on the adipocytokines secretion. For the first time, a trial study conducted to determine the effect of vitamin D on inflammation and the serum levels of omentin and vaspin.

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Short-Term Effect of High-Dose Vitamin D on the Level of Interleukin 10 in Patients with Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Cited by 51 publications

References 24 publications

Environmental control of autoimmune inflammation in the central nervous system

Environmental control of autoimmune inflammation in the central nervous system

High-Dose Vitamin D3 Intake Is Associated with Decreased Symptoms of Multiple Sclerosis

The effects of supplementation with vitamin D on inflammatory biomarkers, omentin, and vaspin in women with type 2 diabetes: A randomized double‐blind placebo‐controlled clinical trial

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