Short-term effect of ambient air pollutant change on the risk of tuberculosis outpatient visits: a time-series study in Fuyang, China

Abstract

There is growing evidence that air pollution plays a role in TB, but few studies have comprehensively included the six common air pollutants. Our objectives were to investigate the association between short-term exposure to six common air pollutants and the risk of tuberculosis outpatient visits in Fuyang, China, during the period 2015-2020. We combined the two models to explore the effects of exposure to six air pollutants on the risk of tuberculosis outpatient visits, including Poisson generalized linear regression model and distributed lag non-linear model (DLNM). We performed stratified analyses for season, gender and age. We used the lag-specific relative risks and cumulative relative risk obtained by increasing pollutant concentration by per 10 units to evaluate the connection between six air pollutants and TB, PM2.5 (RR=1.0018, 95%CI: 1.0004-1.0032, delay of 12 days) and (RR=1.0169,95%CI: 1.0007-1.0333, lag 3 / 31 0-16 days), SO2 were 0.9549 (95%CI: 0.9389-0.9712, lag 0 days) and 0.8212 (95%CI: 0.7351-0.9173, 0-20 days lag). Stratified analyses showed that seasonal differences had a greater impact on TB, and male more likely to develop TB than female, older people more likely to develop TB than younger people. Exposure to O3, CO, PM10, PM2.5, and NO2 increases the risk of TB outpatient visits, except SO2 reduces the risk. Male and elderly people should be protected. We need to pay more attention to the impact of seasonal effects on TB.

Association Between Exposure to Ozone (O3) and the Short-Term Effect on Tuberculosis Outpatient Visits: A Time-Series Study in 16 Cities of Anhui Province, China

“… 37 A study of ambient air pollutants in Fuyang also showed that O 3 exposure is associated with the risk of TB outpatient visits (RR = 1.049, 95% CI: 1.0012–1.0086, 0-day lag). 38 These findings are consistent with the present study, which confirmed that ozone exposure will increase the risk of TB visit for the following possible reasons: It is thought that this phenomenon may be related to the strong oxidizing properties of ozone. As a strong oxidizing gas, ozone can be oxidized at lower temperatures and can participate in a variety of chemical reactions in the atmospheric environment, and it has a severe irritation of the respiratory tract.…”

A systematic review and meta-analysis of the association between air pollutants and the incidence of tuberculosis

“…82 were left after removing duplicates, and then 27 were left after filtering by title. Finally, we accepted 9 articles as the included articles for our research after filtering for the full text and checking references [ 9 , 15 , [17] , [18] , [19] , [20] , [21] , [22] , [23] ].…”

Long-term exposure to ambient fine particulate matter (PM2.5) and attributable pulmonary tuberculosis notifications in Ningxia Hui Autonomous Region, China: a health impact assessment

“…Low-income to middle-income countries account for the greatest proportion of TB cases (>95%) and some of the highest levels of ambient PM 2.5 (population-weighted annual mean PM 2.5 from ~60% to ~75 µg/m 3 ). 4 5 The association between ambient air pollution and TB disease has attracted a modest but growing body of literature, as we highlighted in a 2019 systematic review, 6 various individual studies [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] and a meta-analysis 27 published subsequent to our review. However, most studies have focused on TB-related outcomes among people who already have TB disease (eg, hospitalisations, mortality) while studies of long-term exposure and new TB disease notifications are comparatively scarce, especially in TB-endemic settings.…”