Short-Term CT and MR Changes in Brain Tumors Following 125I Interstitial Irradiation

Moringlane, J. R.; Voges, M.; Huber, G.; Leetz, H. K.

doi:10.1097/00004728-199701000-00003

Cited by 8 publications

(3 citation statements)

References 16 publications

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“…The time course in which we see these imaging effects was similar to that seen for central nervous system tumors treated with radiosurgery or interstitial brachytherapy (20)(21)(22). For example, Moringlane et al (22) noted that a ring-like signal on T 1 -positive contrast images developed as early as 1 month in most of their glioma patients treated with interstitial 125 I. This timing is very consistent with our own observations after GliaSite treatment.…”

Section: Discussionsupporting

confidence: 88%

“…Given that GliaSite treatment often treats the adjoining resection cavity surface to a high radiation dose, our findings are consistent with the T 1 -enhancing lesions we observed as being a type of pseudoprogression that does not signify disease recurrence. The time course in which we see these imaging effects was similar to that seen for central nervous system tumors treated with radiosurgery or interstitial brachytherapy (20)(21)(22). For example, Moringlane et al (22) noted that a ring-like signal on T 1 -positive contrast images developed as early as 1 month in most of their glioma patients treated with interstitial 125 I.…”

Section: Discussionsupporting

confidence: 68%

See 1 more Smart Citation

Imaging After GliaSite Brachytherapy: Prognostic MRI Indicators of Disease Control and Recurrence

Kleinberg¹,

Yoon²,

Weingart³

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 68%

Imaging After GliaSite Brachytherapy: Prognostic MRI Indicators of Disease Control and Recurrence

Kleinberg¹,

Yoon²,

Weingart³

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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“…Even more striking on T 1 -weighted images after administering gadolinium contrast material, than with CT. Numerous papers refer to the radiological lesions after Gamma Knife surgery or interstitial irradiation [2,15,18,22,24,31]. The reactive ring is believed to consist of dilated and proliferating vessels.…”

Section: Discussionmentioning

confidence: 99%

Tissue Response to Iodine-125 Interstitial Brachytherapy of Cerebral Gliomas

Julow

Szeifert

Bálint³

et al. 2007

Radiosurgery and Pathological Fundamentals

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The purpose of this study was to investigate histopathological changes and the role of the microglia/macrophage cell system in the therapeutic effect of iodine-125 ( 125 I) interstitial brachytherapy on cerebral gliomas. Out of a series of 60 cases harboring cerebral astrocytomas and other brain tumors treated with 125 I interstitial brachytherapy, autopsy material was available in 10 cases between 0.75 and 60 months after irradiation. The patients were treated with 60-Gy maximum doses at the tumor periphery. Besides the routine HE and Mallory's PTAH trichrome staining, immunohistochemical reactions were carried out for CD15, CD31, CD34, CD45, CD68 (PG-M1), CPM, HAM 56 and HLA-DR antigens to study immunological characteristics of the reactive cell population around gliomas after 125 I treatment. The present immunohistochemical study demonstrated that the early lesions following 125 I interstitial brachytherapy of gliomas are characterized by migrating macrophages apparently concerned with the removal of necrotic debris. The established phase of reactive zone around the necrotic center disclosed a narrow inner rim of microglial accumulation, and a broad outer area consisting of astrocytic gliosis, vascular proliferation, activated microglia and infiltration by macrophages. In the burned-out phase, the necrosis undergoes liquefaction, the microglial rim is replaced by end-stage macrophages, and the reactive zone is transformed into astrocytic gliosis, which can be considered as equivalent to scar tissue formed around necrosis outside of the central nervous system.

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The Application of Image Fusion in Stereotactic Brachytherapy of Brain Tumours

Julow

Major

Emri

et al. 2000

Acta Neurochirurgica

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On the basis of 20 brachytherapeutic image fusion of stereotactic CT (slices with fiducials) with additional stereotactic CT, MRI, PET and SPECT images provides more accurate and precise target volume, more exact localization of catheters and isotope seeds (verification fusion), differentiation between the localization and amount of the necrotic and proliferating parts of the tumours and shows the volume changes in consequence of interstitial irradiation. The image fusion should help to improve the accuracy and minimize the perifocal morbidity of interstitial irradiation.

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Short-Term CT and MR Changes in Brain Tumors Following 125I Interstitial Irradiation

Cited by 8 publications

References 16 publications

Imaging After GliaSite Brachytherapy: Prognostic MRI Indicators of Disease Control and Recurrence

Imaging After GliaSite Brachytherapy: Prognostic MRI Indicators of Disease Control and Recurrence

Tissue Response to Iodine-125 Interstitial Brachytherapy of Cerebral Gliomas

The Application of Image Fusion in Stereotactic Brachytherapy of Brain Tumours

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