Short-term changes in bone and mineral metabolism following gastrectomy in gastric cancer patients

Baek, Ki Hyun; Jeon, Hae Myung; Lee, Seong Su; Lim, Dong Jun; Oh, Ki Won; Lee, Won Young; Rhee, Eun-Jung; Han, Je Ho; Yun, Bong; Lee, Kwang Woo; Son, Ho Young; Kang, Sung Koo; Kang, Moo Il

doi:10.1016/j.bone.2007.08.027

Cited by 39 publications

(55 citation statements)

References 35 publications

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“…The bone loss during the first year was − 0.9% in the lumbar spine and − 1.3% in the femoral neck compared with basal levels. We previously reported that the cumulative bone loss during the first year after gastrectomy in gastric cancer patients was −5.7% in the lumbar spine and −6.6% in the femoral neck compared with basal levels [5]. We also found that one year after bone marrow transplantation in hematologic malignancy patients, lumbar spine BMD had decreased by 5.9% and total femoral BMD had decreased by 11.3% [6].…”

Section: Discussionmentioning

confidence: 82%

The effects of thyrotropin-suppressing therapy on bone metabolism in patients with well-differentiated thyroid carcinoma

Kim

Yun

Kim

et al. 2015

Bone

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Section: Discussionmentioning

confidence: 82%

The effects of thyrotropin-suppressing therapy on bone metabolism in patients with well-differentiated thyroid carcinoma

Kim

Yun

Kim

et al. 2015

Bone

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“…As opposite to the results obtained in the current studies, earlier investigations on Korean population have revealed different rates of mean bone loss in lumbar spine (–5.7%), total hip (–5.4%), femoral neck (–6.6%), and trochanter (–8.7%) during 1 year after gastrectomy, which was expressed as the percentage change from the baseline. 20 The difference in the scale of bone tissue loss within lumbar spine observed in the previous and the current studies may result from different densitometric techniques. As opposed to the current study, where vBMD was evaluated separately for trabecular and cortical bone compartments with the use of quantitative computed tomography, the previous trial on Korean patients was performed with the use of dual-energy X-ray absorptiometry (DEXA) technique.…”

Section: Discussionmentioning

confidence: 59%

Negative Effects of Total Gastrectomy on Bone Tissue Metabolism and Volumetric Bone Mineral Density (vBMD) of Lumbar Spine in 1-Year Study in Men

Krupski

Tatara

Bury³

et al. 2016

Medicine

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Gastrectomy induces severe osteoporosis in humans but its quantitative scale within trabecular and cortical compartments was not estimated. The aim of the study was to determine changes of volumetric bone mineral density (vBMD) in lumbar vertebrae (L1–L4) and biochemical bone metabolism markers in serum of patients 1 year after total gastrectomy. The control group consisted of patients (N = 8) subjected to abdominal surgery due to cardiospasmus. Total gastrectomy was performed in the experimental group (N = 6).Volumetric bone mineral density of trabecular and cortical bone of lumbar spine was measured before (baseline) and 1 year after the gastric surgery using the quantitative computed tomography method. Serum concentrations of insulin, insulin-like growth factor-1, tyroxine, interleukin-6, C-terminal telopeptides of type II collagen and bone formation, and resorption markers were determined at baseline and 1 year later, using ELISA, EIA, and IEMA methods.Total gastrectomy induced significant decrease of vBMD values, up to 16.8% and 10.0%, within the trabecular and cortical bone compartments of lumbar spine (P < 0.05). These negative changes of vBMD were associated with significantly increased serum concentration of bone resorption markers such as deoxypyridinoline, pyridinoline, and C-terminal telopeptides of type I collagen, by 13.5%, 32.2%, and 121.5%, respectively (P < 0.05). Neither vBMD nor biochemical bone turnover markers and hormone concentrations were influenced in the control patients.Dramatic bone loss during the first year in gastrectomized patients has proven dynamic osteoporosis progress indicating an importance of treatment interventions in these patients with emphasis on inhibition of intensive bone resorption processes.

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“…Annual cortical bone density loss rate in postmenopausal women was determined between 1 and 2%. 17 The observed gastrectomyinduced significant bone loss in the current study was not related to decreased amino acid concentration in plasma obtained from overnight fasted patients. It is interesting to perform determination of amino acid concentration in plasma collected from gastrectomized patients within shorter periods from food intake than the period of overnight fasting.…”

Section: Discussionmentioning

confidence: 64%

“…However, it should be pointed out that the previous study was performed using dual-energy X-ray absorptiometry (DEXA) method and instead of separately determined changes of vBMD for the trabecular and cortical bone compartments, areal BMD measurements for all vertebrae were presented. 17 Other studies in USA population on gastrectomized patients with the use of DEXA method have revealed 14.1% bone loss in lumbar spine, expressed as a decrease of BMD value. Male patients in those investigations were at mean age of 71.5 years exhibiting nearly 15 years more advanced age in comparison to the current study.…”

Section: Discussionmentioning

confidence: 99%

Effects of total gastrectomy on plasma silicon and amino acid concentrations in men

Tatara

Krupski

Szpetnar

et al. 2015

Exp Biol Med (Maywood)

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The aim of the study was to determine one-year effects of total gastrectomy on plasma silicon and free amino acid concentrations in patients and evaluate changes of volumetric bone mineral density (vBMD) in lumbar spine. Eight patients were enrolled to the control (CTR) group. Six patients subjected to total gastrectomy (GX group) were included to the experimental group. vBMD in trabecular and cortical bone was measured in lumbar vertebrae at baseline (before surgery) and one year later using quantitative computed tomography. Plasma concentrations of silicon and free amino acids were determined at baseline and one year later using photometric method and ion-exchange chromatography. Body weights within CTR and GX groups were not different after one-year follow-up when compared to the baseline values (P > 0.05). An average annual decrease of vBMD in the trabecular bone in the gastrectomized patients reached 15.0% in lumbar spine and was significantly different in comparison to the percentage changes observed in CTR group (P ¼ 0.02). One-year percentage change of vBMD in the cortical bone in L 1 and L 2 has shown significantly decreased values by 10.5 and 9.1% in the GX group when compared to the percentage change observed in the controls (P < 0.05). Plasma concentration of adipic acid was significantly higher by 101.6% one year after total gastrectomy procedure in the patients when compared to the baseline value (P ¼ 0.01). Plasma concentration of silicon was significantly lowered by 26.7% one year after the total gastrectomy when compared to the baseline value (P ¼ 0.009). Total gastrectomy in patients has induced severe osteoporotic changes in lumbar spine within one-year period. The observed osteoporotic changes were associated with decreased plasma concentration of silicon indicating importance of exocrine and endocrine functions of stomach for silicon homeostasis maintenance. Gastrectomy-induced bone loss was not related to decreased amino acid concentration in plasma obtained from overnight fasted patients.

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Short-term changes in bone and mineral metabolism following gastrectomy in gastric cancer patients

Cited by 39 publications

References 35 publications

The effects of thyrotropin-suppressing therapy on bone metabolism in patients with well-differentiated thyroid carcinoma

The effects of thyrotropin-suppressing therapy on bone metabolism in patients with well-differentiated thyroid carcinoma

Negative Effects of Total Gastrectomy on Bone Tissue Metabolism and Volumetric Bone Mineral Density (vBMD) of Lumbar Spine in 1-Year Study in Men

Effects of total gastrectomy on plasma silicon and amino acid concentrations in men

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