Short-Term and Long-Term Intra-Individual Variations and Critical Differences of Haematological Laboratory Parameters

Abstract

Summary:The complete blood cell count and the differential leukocyte count have been studied for their variations within-one-day and during one weck (short-term variations) and during a period of six months (long-term variations) with an automatic haematology analyser (H-6000, Technicon®), in which some new Parameters (large unstained cells, high peroxidase cells, red cell distribution width, platelet distribution width, mean platelet volume, plateletcrit) are included. The influence of external factors such äs sex-differences, smoking/non-smoking, üse of oral contraceptives etc. have also been studied. It appears that the use of critical differences together with haematological data improves the value of these parameters in diagnosis and treatment of patients. Laboratoriumskenngrößen. Kurz-und langzeitige intra-individuelle Änderungen sowie kritische Differenzen hämatologischer

Relationship of airborne microorganisms with the lung function and leucocyte levels of workers with a history of humidifier fever.

“…The criterion used is in close agreement with reference values published by Costongs et al (22). With this criterion the population was dichotomized , P<0.05 (paired t-test, one-sided), " P<O.Ol (paired t-test, one sided).…”

Genetic and environmental causes of variation in basal levels of blood cells

“…Red cel l and pl atel et i ndi ces change l i ttl e over the course of 12 months, w hi l st l evel s of the vari ous l eukocyte sub-types exhi bi t more vari ati on. [1][2][3][4] The exi stence of steady state l evel s across ti me for many bl ood cel l counts i mpl i es that these i ndi ces are subject to homeostati c regul ati on. A n understandi ng of the factors underl yi ng thi s homeostasi s i s desi rabl e not onl y from a theoreti cal perspecti ve, but al so practi cal l y, i n terms of i denti fyi ng new therapeutic possibilities in pathological states characteri sed by abnormal bl ood cel l counts (eg i di opathi c apl asti c anaemi a, neutropeni a etc).…”

Laboratory hematology in the history of Clinical Chemistry and Laboratory Medicine

“…In 1985 Costongs et al were the first to present data that proved to be useful for the interpretation of repeat measurements in a single individual, initially for cellular parameters and soon for routine coagulation assays as well [28,29] . Biological variability data have later been used for defining analytical goals in coagulation testing [30] .…”

“…With regards to authorship or co-authorship, my analysis demonstrates that Dr. Jan van Wersch (the Netherlands) has contributed the most LH papers to the journal: 22 over a period of 14 years. His first publication was in 1985 as a co-author of the paper on biological variability [28] and his last was in 1997 on coagulation and fibrinolysis, which was his predominant field of expertise [54] . The second author who published frequently on LH subjects in the journal is Professor Giuseppe Lippi (Italy), who (co)-authored 18 LH papers in 18 years, starting in 1994 with an article on neutrophils [55] and very recently one on pre-analytical phase [56] .…”