Short stature is an inflammatory disadvantage among middle-aged Japanese men

Shimizu, Yūji; Yoshimine, Hiroyuki; Nagayoshi, Mako; Kadota, Koichiro; Takahashi, Kensuke; Izumino, Kiyohiro; Inoue, Kenichiro; Maeda, Takahiro

doi:10.1007/s12199-016-0538-y

Cited by 25 publications

(33 citation statements)

References 21 publications

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“…In the present study, to evaluate the influence of height on progressive vascular remodeling, further analyses showed no-significant association between height and CIMT for subjects with both high and low hemoglobin; fully-adjusted standardized parameter estimates (β) and p-values were β = −0.001, p = 0.992 for subjects with high hemoglobin and β = 0.11, p = 0.290 for subjects with low hemoglobin. Since our present study population comprised individuals within the normal BMI range (18.5-24.9 kg/m 2 ) our present results are compatible with those of previous studies we conducted [2,5]. However, atherosclerosis (increased CIMT) is only one aspect of vascular repair (aggressive endothelial repair).…”

Section: Discussionsupporting

confidence: 89%

“…In a previous study, we reported an inverse association between height and high white blood cell count in those with a BMI ≥ 23kg/m 2 but not with a BMI < 23 kg/m 2 [5]. Since a high white blood cell count, which indicates elevated inflammatory activity, is significantly positively associated with atherosclerosis [4], height may be inversely associated with this disease.…”

Section: Discussionmentioning

confidence: 80%

“…Atherosclerosis is known to be a chronic inflammatory disease [3], and a higher white blood cell count has also been identified as a marker of systemic inflammatory activity that is known to be associated with atherosclerosis [4]. In connection with these phenomena, we also reported that short stature is associated with inflammatory disadvantages since high white blood cell count is inversely associated with height in subjects with a body mass index (BMI) ≥ 23 kg/m 2 but not in those with a BMI < 23 kg/m 2 [5]. Additionally, an Asian-specific inflammation-related single nucleotide polymorphism (SNP) (rs3782886) was also revealed to be significantly associated with short stature [6].…”

Section: Introductionmentioning

confidence: 78%

“…Short stature entails a higher risk of endothelial impairment [2] such as chronic inflammation [5,6], which stimulates endothelial repair activity. Since endothelial activity is closely associated with bone marrow activity [13,23], which is also strongly influenced by age-related decline [14,25], an analysis limited to subjects with high bone marrow activity (high hemoglobin) should strengthen the influence of endothelial repair.…”

Section: Discussionmentioning

confidence: 99%

“…If aggressive vascular repair is evoked by serious endothelial damage, the maximum ability of vascular repair should be defined by height-subjects with a short stature would not activate vascular repair as strongly as subjects with a tall stature (ceiling effect). Since short stature is associated with inflammatory disadvantages [5,6], this type of ceiling effect should act as a strong confounding factor on the association between height and platelet count. We also previously reported that height is positively associated with hematopoietic capacity [27], and bone marrow stroma cells differentiate into megakaryocytes that subsequently produce platelets [29].…”

Section: Discussionmentioning

confidence: 99%

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2018

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Height is reported to be inversely associated with cardiovascular disease. And platelets play an important role in vascular remodeling by supporting CD34-positive cells. To clarify the association between height and platelet, we conducted a crosssectional study of 219 elderly Japanese men. Since hemoglobin concentration is influenced by vascular remodeling activity, an analysis stratified by hemoglobin level was performed. An inverse association was seen between height and platelet count in subjects with a high hemoglobin concentration (≥ 14.5 g/dL), but not in subjects with a low hemoglobin concentration (< 14.5 g/dL). The standardized parameter estimates (β) were β = −0.22, p = 0.019 for subjects with high hemoglobin, and β = −0.01, p = 0.931 for subjects with low hemoglobin. We also found a positive association between platelets and carotid intima media thickness (CIMT) and circulating CD34-positive cells in subjects with high hemoglobin (partial correlation coefficient (r) = 0.21, p = 0.037 and r = 0.40, p =< 0.001), but not in subjects with low hemoglobin (r = 0.04, p = 0.710 and r = 0.06, p = 0.544). In subjects with a high hemoglobin concentration, platelets were inversely associated with height, and positively associated with CIMT and circulating CD34-positive cells. These results indicate that subjects with a short stature activate vascular remodeling to a much greater extent than subjects with a tall stature.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 80%