Association of short stature and obesity with cardio-metabolic risk factors in Iranian children and adolescents: the CASPIAN-V study

Safari, Omid; Ejtahed, Hanieh‐Sadat; Namazi, Nazli; Heshmat, Ramin; Arjmand, Reza; Saleh, Shahrokh Karbalahi; Seif, Ehsan; Shahsanai, Armindokht; Motlagh, Mohammad Esmaeil; Abdar, Mohammad Esmaeili; Qorbani, Mostafa; Kelishadi, Roya

doi:10.1007/s40200-021-00831-1

Cited by 2 publications

(4 citation statements)

References 24 publications

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“…We observed a positive correlation between UHR and ALT. Previous studies that have directly explored UHR and ALT are limited, but UHR is a new metabolic predictor with high sensitivity and specificity compared to other metabolic syndrome diagnostic criteria ( 15 ). Regarding the association between UHR and ALT, Mehmet Ali Kosekli et al observed that UHR was positively associated with ALT through a controlled study ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

“…Children and adolescents with short stature not only have height problems but also, more importantly, have abnormal metabolic function ( 14 ). Existing studies have shown that children with short stature have higher odds of developing metabolic syndrome compared to the normal height group, which leads to a greatly increased chance of cardiovascular events in the future ( 15 ). Recently, it has been reported that the uric acid to high density lipoprotein cholesterol ratio (UHR) is a new inflammatory and metabolic indicator.…”

Section: Introductionmentioning

confidence: 99%

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Association between the uric acid to high density lipoprotein cholesterol ratio and alanine transaminase in Chinese short stature children and adolescents: A cross-sectional study

Zhao

Zhang

et al. 2023

Front. Nutr.

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ObjectiveUric acid to high-density lipoprotein cholesterol ratio (UHR), the ratio of uric acid to high-density lipoprotein cholesterol, is a newly proposed marker of metabolic abnormalities. There are few previous studies directly investigating the relationship between UHR and alanine aminotransferase (ALT), especially in short stature populations, however, short stature children and adolescents are more likely to have metabolic disorders. This research aimed to investigate the relationship between the UHR and ALT in children and adolescents with short stature.MethodsIn this cross-sectional analysis, the clinical data of 1,510 children with height below −2 SD who were evaluated at the Department of Endocrinology, Affiliated Hospital of Jining Medical University from 1 March 2013 to 31 December 2021, were selected. Anthropometric and biochemical indicators were measured. The relationship between UHR and ALT was analysed.ResultsThe univariate analysis results showed that UHR was positively associated with ALT (β = 0.43, P < 0.0001). Furthermore, after adjusting for possible confounding factors, a non-linear relationship was detected between UHR and ALT through smooth curve fitting, and the inflection point of UHR was 10.93% after multivariate piecewise linear regression analysis. ALT increased with UHR elevation when the UHR was greater than 10.93% (β = 0.69, 95% CI 0.39, 0.98; P < 0.0001). However, we did not observe a significant relationship when the UHR was less than 10.93% (P = 0.9229).ConclusionOur study demonstrated that in Chinese children and adolescents with short stature, UHR may be associated with the regulation of ALT levels, and this relationship merits further investigation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between the uric acid to high density lipoprotein cholesterol ratio and alanine transaminase in Chinese short stature children and adolescents: A cross-sectional study

Zhao

Zhang

et al. 2023

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…We observed a positive correlation between UHR and ALT. Previous studies that have directly explored UHR and ALT are limited, but UHR is a new metabolic predictor with high sensitivity and speci city compared to other metabolic syndrome diagnostic criteria [19]. Regarding the association between UHR and ALT, Mehmet Ali Kosekli et al observed that UHR was positively associated with ALT through a controlled study [24].…”

Section: Discussionmentioning

confidence: 99%

“…Children and adolescents with short stature not only have height problems but also, more importantly, have abnormal metabolic function [18]. Existing studies have shown that children with short stature have higher odds of developing metabolic syndrome compared to the normal height group, which leads to a greatly increased chance of cardiovascular events in the future [19]. Recently, it has been reported that the uric acid to high density lipoprotein cholesterol ratio (UHR) is a new in ammatory and metabolic indicator.…”

Section: Introductionmentioning

confidence: 99%

Association between the uric acid to high density lipoprotein cholesterol ratio and alanine transaminase in Chinese short stature children and adolescents: a cross-sectional study

Zhao

Zhang

et al. 2022

Preprint

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Objective This research aimed to investigate the relationship between the uric acid to high-density lipoprotein cholesterol ratio (UHR) and alanine aminotransferase (ALT) in children and adolescents with short stature. Methods In this cross-sectional analysis, the clinical data of 1510 children with height below − 2 SD who were evaluated at the Department of Endocrinology, Affiliated Hospital of Jining Medical University from March 1, 2013, to December 31, 2021, were selected. Anthropometric and biochemical indicators were measured.The relationship between UHR and ALT was analysed. Results The univariate analysis results showed that UHR was positively associated with ALT (β 0.43, P < 0.0001). Furthermore, after adjusting for possible confounding factors,a nonlinear relationship was detected between UHR and ALT through smooth curve fitting, and the inflection point of UHR was 10.93% after multivariate piecewise linear regression analysis. ALT increased with UHR elevation when the UHR was greater than 10.93% (β 0.69, 95% CI 0.39, 0.98; P < 0.0001). However, we did not observe a significant relationship when the UHR was less than 10.93% (P = 0.9229). Conclusion Our study demonstrated that in Chinese children and adolescents with short stature, UHR may be associated with the regulation of ALT levels, and this relationship merits further investigation.

show abstract

Association of short stature and obesity with cardio-metabolic risk factors in Iranian children and adolescents: the CASPIAN-V study

Cited by 2 publications

References 24 publications

Association between the uric acid to high density lipoprotein cholesterol ratio and alanine transaminase in Chinese short stature children and adolescents: A cross-sectional study

Association between the uric acid to high density lipoprotein cholesterol ratio and alanine transaminase in Chinese short stature children and adolescents: A cross-sectional study

Association between the uric acid to high density lipoprotein cholesterol ratio and alanine transaminase in Chinese short stature children and adolescents: a cross-sectional study

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