Short Sleep Duration Is Associated with Shorter Telomere Length in Healthy Men: Findings from the Whitehall II Cohort Study

Jackowska, Marta; Hamer, Mark; Carvalho, Lívia A.; Erusalimsky, Jorge D.; Butcher, Lee; Steptoe, Andrew

doi:10.1371/journal.pone.0047292

Cited by 114 publications

(74 citation statements)

References 39 publications

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“…1–5 While long and short sleep duration have been associated with adverse health outcomes, 6–9 including cardiovascular disease (CVD), diabetes, obesity and mortality, short sleep duration in particular may have a deleterious impact on health, appearing to deregulate physiological processes relating to appetite 1011 and glucose metabolism, 12 and has also been associated with shorter telomere length. 13 Not all segments of the population, however, appear to have equal distributions of sleep duration. Disparities have been noted by race/ ethnicity 1415 and socioeconomic status (SES), 1617 with shorter sleep duration in those with low SES and in minority populations.…”

Section: Introductionmentioning

confidence: 99%

Geographic variations in sleep duration: a multilevel analysis from the Boston Area Community Health (BACH) Survey

Fang

Subramanian

Piccolo

et al. 2014

J Epidemiol Community Health

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Background Sleep plays an important role in health and varies by social determinants. Little is known, however, about geographic variations in sleep and the role of individual-level and neighbourhood-level factors. Methods We used a multilevel modelling approach to quantify neighbourhood variation in self-reported sleep duration (very short <5 h; short 5–6.9 h; normative 7–8.9 h; long ≥9 h) among 3591 participants of the Boston Area Community Health Survey. We determined whether geographic variations persisted with control for individual-level demographic, socioeconomic status (SES) and lifestyle factors. We then determined the role of neighbourhood SES (nSES) in geographic variations. Additional models considered individual health factors. Results Between neighbourhood differences accounted for a substantial portion of total variability in sleep duration. Neighbourhood variation persisted with control for demographics, SES and lifestyle factors. These characteristics accounted for a portion (6–20%) of between-neighbourhood variance in very short, short and long sleep, while nSES accounted for the majority of the remaining between-neighbourhood variances. Low and medium nSES were associated with very short and short sleep (eg, very short sleep OR=2.08; 95% CI 1.38 to 3.14 for low vs high nSES), but not long sleep. Further inclusion of health factors did not appreciably increase the amount of between-neighbourhood variance explained nor did it alter associations. Conclusions Sleep duration varied by neighbourhood in a diverse urban setting in the northeastern USA. Individual-level demographics, SES and lifestyle factors explained some geographic variability, while nSES explained a substantial amount. Mechanisms associated with nSES should be examined in future studies to help understand and reduce geographic variations in sleep.

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Section: Introductionmentioning

confidence: 99%

Geographic variations in sleep duration: a multilevel analysis from the Boston Area Community Health (BACH) Survey

Fang

Subramanian

Piccolo

et al. 2014

J Epidemiol Community Health

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“…In addition, stratifying by lung function within the group of healthy smokers (current and ex-smokers) did not clarify the issue, although for FVC, an effect could be detected in smokers of the lower quartile. The underlying reason for not detecting an effect may be found in the complex interactions between smoking and genetic and/or lifestyle factors, such as dietary antioxidants or physical activity, affecting biological age and its markers [1,3,[27][28][29][30][31][32], but also in the heterogeneity of smoking exposure, and its amount and duration.…”

Section: Discussionmentioning

confidence: 99%

Telomere length in circulating leukocytes is associated with lung function and disease

Albrecht¹,

Sillanpää²,

Karrasch³

et al. 2013

European Respiratory Journal

108

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Several clinical studies suggest the involvement of premature ageing processes in chronic obstructive pulmonary disease (COPD). Using an epidemiological approach, we studied whether accelerated ageing indicated by telomere length, a marker of biological age, is associated with COPD and asthma, and whether intrinsic age-related processes contribute to the interindividual variability of lung function.Our meta-analysis of 14 studies included 934 COPD cases with 15 846 controls defined according to the Global Lungs Initiative (GLI) criteria (or 1189 COPD cases according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria), 2834 asthma cases with 28 195 controls, and spirometric parameters (forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC) of 12 595 individuals. Associations with telomere length were tested by linear regression, adjusting for age, sex and smoking status.We observed negative associations between telomere length and asthma (b5 -0.0452, p50.024) as well as COPD (b5 -0.0982, p50.001), with associations being stronger and more significant when using GLI criteria than those of GOLD. In both diseases, effects were stronger in females than males. The investigation of spirometric indices showed positive associations between telomere length and FEV1 (p51.07610 -7 ), FVC (p52.07610 -5 ), and FEV1/FVC (p55.27610 -3 ). The effect was somewhat weaker in apparently healthy subjects than in COPD or asthma patients.Our results provide indirect evidence for the hypothesis that cellular senescence may contribute to the pathogenesis of COPD and asthma, and that lung function may reflect biological ageing primarily due to intrinsic processes, which are likely to be aggravated in lung diseases. @ERSpublicationsTelomere length is decreased in asthma and COPD patients and positively associated with spirometric indices

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“…В когортном исследовании Whitehall II приняли участие 434 человека (47,5% мужчин и 52,5% жен-щин), средний возраст которых составлял 63,3 года [34]. Участники ответили на вопросы о статусе курения, возрасте, уровне образования и занятости, индексе мас-сы тела (ИМТ) и т.п.…”

Section: продолжительность сна и длина теломерunclassified

Sleep Duration: Modern View of the Problem From the Standpoint of a Cardiologist

Драпкина

Shepel

2015

Racionalʹnaâ farmakoterapiâ v kardiologii

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Введение «Сон -это особое генетически детерминированное состояние организма теплокровных животных (мле-копитающих и птиц), характеризующееся закономер-ной последовательной сменой определенных поли-графических картин в виде циклов, фаз и стадий» [1]. Сон является неоднородным процессом и представляет собой последовательность функциональных состояний головного мозга: фазы медленного сна (ортодоксаль-ный сон, сон без сновидений) и фазы быстрого сна (па-радоксальный сон, сон со сновидениями или REM-фаза). Нормальный восьмичасой сон состоит из 4-6 вол-нообразных циклов, каждый из которых длится около 90 минут. При этом фаза медленного сна занимает 75-85% от всего времени сна, а фаза быстрого сна -до 25%.Сон необходим для физического и психического здо-ровья. Потеря или нарушение продолжительности сна влечет за собой нарушение функции различных орга-нов и систем. Национальная комиссия по исследова-нию расстройств сна у жителей США отмечает, что 36% взрослых людей имеют проблемы, связанные с его на-рушениями. При этом около 40 млн американцев страдают хроническими нарушениями сна, а у 20-30 млн инсомния носит периодический характер, что создает угрозу возникновения различных заболеваний [2]. В России около 45% взрослых людей не удовле-творены качеством и продолжительностью своего сна, а почти 20% нуждаются в серьезном лечении нарушений сна [3].На продолжительность и качество сна влияют раз-личные факторы: генетические, биологические, пове-денческие, экологические, социальные и другие. Дли-тельное воздействие этих факторов вызывает каскад из-менений в организме человека, результатом которых яв-ляется развитие ряда заболеваний, в том числе и сер-дечно-сосудистой системы (рис. 1). Продолжительность сна и общая смертностьПервоначально эксперименты, целью которых было определение связи длительности сна и риска возник-новения заболеваний, проводились на животных. До-статочно революционными для своего времени были опыты М.М. Манасеиной, которые стали пионерскими в данном направлении. В 1880-1890-х годах с целью В настоящее время известна и доказана роль нарушений продолжительности сна в развитии различных хронических заболеваний, включая заболевания сердечно-сосудистой системы. Кроме того, результаты многих клинических исследований демонстрируют связь между нарушением продолжительности сна и скоростью уко-рочения теломер. В свою очередь, короткие теломеры ассоциируются с развитием артериальной гипертонии, хронической сердечной недостаточности, атеросклеро-за и других заболеваний, летальность от которых в России и в мире в целом остается высокой. В данной статье представлен обзор клинических исследований, дока-зывающих негативное влияние нарушений продолжительности сна на общую и сердечно-сосудистую смертность, а также подробно рассматриваются работы, в кото-рых установлена связь между продолжительностью сна и длиной теломер. Today the role of disturbances in sleep duration in the development of various chronic diseases, including cardiovascular diseases is known and proven. In addition, the results of many clinical studies de...

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Short Sleep Duration Is Associated with Shorter Telomere Length in Healthy Men: Findings from the Whitehall II Cohort Study

Cited by 114 publications

References 39 publications

Geographic variations in sleep duration: a multilevel analysis from the Boston Area Community Health (BACH) Survey

Geographic variations in sleep duration: a multilevel analysis from the Boston Area Community Health (BACH) Survey

Telomere length in circulating leukocytes is associated with lung function and disease

Sleep Duration: Modern View of the Problem From the Standpoint of a Cardiologist

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