Short Report: Long-Term Serum Antibody Isotype Responses to Strongyloides stercoralis Filariform Antigens in Eight Patients Treated with Ivermectin

Lindo, John; Atkins, N.S.; Lee, Michael G.; Robinson, R. D.; Bundy, Donald

doi:10.4269/ajtmh.1996.55.474

Cited by 13 publications

(11 citation statements)

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“…In patients with hydatid disease, specific IgE antibodies constitute about 8 % of total serum IgE (Dessaint et al, 1975); and after efficient treatment, specific IgE antibodies decrease to a low level or disappear within six to twelve months (Bekhti et al, 1977). In patients with strongyloidiasis, specific IgE antibodies levels decrease toward zero within also six to twelve months after efficient treatment with ivermectine (Lindo et al, 1996). IgE have a short half-life (three to four days) in serum, but may persist some months in tissues, being binded to surface receptors.…”

Section: Discussionmentioning

confidence: 99%

A three years follow-up of total serum IgE levels in three patients treated for strongyloidiasis

Poirriez¹

2001

Parasite

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Summary :A three years follow-up of the level of serum total IgE was made for the first time in three patients with strongyloidiasis after efficient treatment. The decrease of IgE was slow and progressive, showing a logarithmic curve. This regular decrease of total serum IgE could be used as an additional criterion for the evaluation of the efficiency of drug therapy in patients with strongyloidiasis. The persistence of high levels of total IgE two or three years after the elimination of the intestinal parasites, after the return of blood eosinophils to a normal level (within six months], and after the disappearance of specific antibodies, shows that the regulation of the IgE elimination seems to be a complex mechanism.KEY WORDS : strongyloidiasis, total serum IgE, elimination. Résumé : ÉTUDE DE L' ÉVOLUTION DURANT TROIS ANS DU TAUX DES IGE SÉRIQUES TOTALES, CHEZ TROIS PATIENTS TRAITÉS POUR ANGUILLULOSE

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Section: Discussionmentioning

confidence: 99%

A three years follow-up of total serum IgE levels in three patients treated for strongyloidiasis

Poirriez¹

2001

Parasite

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“…Previous studies showed that the level of antibodies decrease after treatment, usually after a period of less than a year. 30,32 Many studies propose the hypothesis that the serologic assay might be more sensitive than the stool assay. 32,33 Bailey studied a group of patients with clinical signs of strongyloidiasis, including larva currens and urticaria, and found high levels of anti-IgG in the absence of larvae in the stools.…”

Section: Discussionmentioning

confidence: 99%

“…20 The specificity of the test observed in the present study was similar to the results reported in immunocompetent people, which ranged from 82% to 100%. 14,15,18,27,30,31 Although sensitivity and specificity are intrinsic properties of any given test, the positive and negative predictive values are the most useful information for the user of the test because they represent the rate of true positive and true negative cases, with the results varying depending on the prevalence of the infection in the study area. In our study, the positive predictive value of the ELISA was very low, reflecting a very high rate of false-positive results (half of the positive results).…”

Section: Discussionmentioning

confidence: 99%

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The value of an immunoenzymatic test (enzyme-linked immunosorbent assay) for the diagnosis of strongyloidiasis in patients immunosuppressed by hematologic malignancies.

Schaffel¹,

Nucci²,

Carvalho³

et al. 2001

The American Journal of Tropical Medicine and Hygiene

105

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Abstract. The diagnosis of strongyloidiasis relies upon the identification of the parasite in stool samples. In 1981, a serologic assay was developed, which was useful in the diagnosis of strongyloidiasis in the immunocompetent host. In the present study, we evaluated the enzyme-linked immunosorbent assay (ELISA) in patients with hematologic malignancies. Between April 1995 and December 1998, sera from 164 consecutive patients were tested for the presence of IgG antibody to Strongyloides stercoralis. Patient was considered uninfected after at least three negative stool examinations. The prevalence of strongyloidiasis was 13%. The underlying diseases were acute leukemia in 21% and lymphoma in 52% of the patients. The majority of the patients were receiving chemotherapy (93%) and steroids (76%). The sensitivity, specificity, and positive and negative predictive values were 68%, 89%, 48%, and 95%, respectively. The ELISA may be an excellent assay to rule out the diagnosis of strongyloidiasis in patients with hematologic malignancies.

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“…Although serology has been used as a test of cure in a small number of patients, large-scale studies have not been done. [33][34][35][36] The objective of this study was to evaluate the demographic, clinical, and laboratory features of individuals with proven strongyloidiasis, and to assess the sensitivity of the Centers for Disease Control and Prevention (CDC) Strongyloides EIA and its utility as a test of cure after treatment.…”

Section: Introductionmentioning

confidence: 99%

Serology and eosinophil count in the diagnosis and management of strongyloidiasis in a non-endemic area.

Loutfy

Wilson²,

Keystone³

et al. 2002

The American Journal of Tropical Medicine and Hygiene

184

143

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Abstract. Strongyloidiasis is a chronic infection that may result in significant morbidity; however, diagnosis and management remain problematic. The objective of this study was to 1) evaluate the demographic, clinical, and laboratory features of 76 consecutive individuals who had Strongyloides stercoralis larvae identified in their fecal specimens; 2) determine the sensitivity of the Centers for Disease Control and Prevention (CDC) enzyme immunoassay (EIA) for detecting antibodies to Strongyloides in those with confirmed infection; and 3) assess the serologic responses and changes in eosinophil counts following treatment. Most (96%) cases occurred in immigrants, but some patients had immigrated as long as 40 years earlier. The CDC Strongyloides EIA had a sensitivity of 94.6% (95% confidence interval ‫ס‬ 92.0-97.2%) in this patient population with proven infection. Serologic and eosinophil counts decreased after therapy, suggesting that they may be useful markers of treatment success.

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Short Report: Long-Term Serum Antibody Isotype Responses to Strongyloides stercoralis Filariform Antigens in Eight Patients Treated with Ivermectin

Cited by 13 publications

References 0 publications

A three years follow-up of total serum IgE levels in three patients treated for strongyloidiasis

A three years follow-up of total serum IgE levels in three patients treated for strongyloidiasis

The value of an immunoenzymatic test (enzyme-linked immunosorbent assay) for the diagnosis of strongyloidiasis in patients immunosuppressed by hematologic malignancies.

Serology and eosinophil count in the diagnosis and management of strongyloidiasis in a non-endemic area.

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