A three years follow-up of total serum IgE levels in three patients treated for strongyloidiasis

Poirriez, J.

doi:10.1051/parasite/2001084359

Cited by 6 publications

(4 citation statements)

References 6 publications

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“…It is well known that helminth parasites are potent inducers of IgE production . So far, only a few longitudinal studies have been performed to study the effect of anthelmintic treatment on polyclonal IgE levels . In line with our findings, Cooper et al.…”

Section: Discussionsupporting

confidence: 92%

The effect of three‐monthly albendazole treatment on Th2 responses: Differential effects on IgE and IL‐5

Ruiter

Tahapary

Wammes

et al. 2017

Parasite Immunology

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Helminth parasites induce a strong Th2 response, characterized by high levels of IgE and elevated signature cytokines such as IL-5. As many global deworming programmes are underway, there is concern that this might lead to emergence of Th1-mediated pathologies when the counterbalancing helminth-induced Th2 response is absent. Therefore, we assessed the effect of deworming on Th2-mediated responses in a household-clustered randomized controlled trial in Indonesia. Total plasma IgE and whole-blood IL-5 responses to mitogen phytohaemagglutinin (PHA) were measured in 1494 and 682 subjects, respectively, at baseline, 9 and 21 months after three-monthly single-dose treatment with albendazole or placebo. Anthelmintic treatment did not result in complete removal of helminth infections in the community. However, treatment significantly decreased IgE levels in albendazole- compared to placebo-treated subjects. IL-5 responses to PHA were not significantly affected by anthelmintic treatment and tended to increase in albendazole-treated subjects, indicating that intensive treatment of helminth parasites has different outcomes on B-cell (IgE levels) and T-cell (IL-5) responses. The data shows that 2 years of deworming can have differential effects on responses typified as Th2-mediated, which needs to be taken into account when examining the impact of helminths on noncommunicable diseases.

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Section: Discussionsupporting

confidence: 92%

The effect of three‐monthly albendazole treatment on Th2 responses: Differential effects on IgE and IL‐5

Ruiter

Tahapary

Wammes

et al. 2017

Parasite Immunology

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“…Investigations of IgE in helminth-exposed populations or infected patient groups have examined the effects on IgE levels of anthelmintic treatment [ 16 - 18 ] and the effects of migration on IgE levels in individuals that migrate from endemic to non-endemic countries. Studies of the effects of anthelmintic treatment on IgE levels have shown that levels of IgE remain highly elevated 2 to 3 years after providing effective anthelmintic treatment [ 16 , 17 ]. A study of 34 expatriates with filarial helminth infections and provided effective anthelmintic treatment showed that the mean IgE level fell to within normal limits after a median of 33 months [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Environmental determinants of total IgE among school children living in the rural Tropics: importance of geohelminth infections and effect of anthelmintic treatment

Cooper

Alexander

Moncayo³

et al. 2008

BMC Immunol

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Background: The environmental factors that determine the elevated levels of polyclonal IgE observed in populations living in the Tropics are poorly understood but may include geohelminth infections. We investigated the association between geohelminth infections and total IgE levels in school children in rural tropical Ecuador, and assessed the effect on IgE of repeated anthelmintic treatments over a period of 12 months. The study was nested within a clusterrandomized study that randomized 68 schools to receive either 400 mg of albendazole every 2 months over a year or no treatment. We studied random samples of children completing follow-up and representing four groups stratified by the presence of geohelminth infection at baseline and treatment allocation. We measured levels of total IgE and anti-A. lumbricoides IgG (used as a measure of past and current geohelminth infectious exposure) in blood samples collected at the start of the study and after 12 months.

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“…Loutfy et al, in their study have suggested that serological tests mainly EIA with serial eosinophil counts could be used to monitor the response to the treatment [ 76 ]. In a study involving 3 patients with strongyloidiasis, serial total IgE levels decreased after effective treatment indicating a possibility of using serial total IgE levels in monitoring the response to treatment [ 111 ]. As no prospective studies were done in this direction, it would be very difficult to determine which test would be the test-of-cure for strongyloidiasis [ 76 ].…”

Section: Managementmentioning

confidence: 99%

Intestinal strongyloidiasis and hyperinfection syndrome

2006

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In spite of recent advances with experiments on animal models, strongyloidiasis, an infection caused by the nematode parasite Strongyloides stercoralis, has still been an elusive disease. Though endemic in some developing countries, strongyloidiasis still poses a threat to the developed world. Due to the peculiar but characteristic features of autoinfection, hyperinfection syndrome involving only pulmonary and gastrointestinal systems, and disseminated infection with involvement of other organs, strongyloidiasis needs special attention by the physician, especially one serving patients in areas endemic for strongyloidiasis. Strongyloidiasis can occur without any symptoms, or as a potentially fatal hyperinfection or disseminated infection. Th2 cell-mediated immunity, humoral immunity and mucosal immunity have been shown to have protective effects against this parasitic infection especially in animal models. Any factors that suppress these mechanisms (such as intercurrent immune suppression or glucocorticoid therapy) could potentially trigger hyperinfection or disseminated infection which could be fatal. Even with the recent advances in laboratory tests, strongyloidiasis is still difficult to diagnose. But once diagnosed, the disease can be treated effectively with antihelminthic drugs like Ivermectin. This review article summarizes a case of strongyloidiasis and various aspects of strongyloidiasis, with emphasis on epidemiology, life cycle of Strongyloides stercoralis, clinical manifestations of the disease, corticosteroids and strongyloidiasis, diagnostic aspects of the disease, various host defense pathways against strongyloidiasis, and available treatment options.

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A three years follow-up of total serum IgE levels in three patients treated for strongyloidiasis

Cited by 6 publications

References 6 publications

The effect of three‐monthly albendazole treatment on Th2 responses: Differential effects on IgE and IL‐5

The effect of three‐monthly albendazole treatment on Th2 responses: Differential effects on IgE and IL‐5

Environmental determinants of total IgE among school children living in the rural Tropics: importance of geohelminth infections and effect of anthelmintic treatment

Intestinal strongyloidiasis and hyperinfection syndrome

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