The effect of three‐monthly albendazole treatment on Th2 responses: Differential effects on IgE and <scp>IL</scp>‐5

Ruiter, Karin de; Tahapary, Dicky L.; Wammes, Linda J.; Wiria, Aprilianto E.; Hamid, Firdaus; Lieshout, Lisette van; Smit, Johannes W. A.; Houwing-Duistermaat, Jeanine J.; Sartono, Erliyani; Supali, Taniawati; Yazdanbakhsh, Maria

doi:10.1111/pim.12428

Cited by 8 publications

(6 citation statements)

References 27 publications

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“…These findings are in agreement with our previous results which showed that albendazole treatment leads to a decrease in total IgE levels [27-29]. Likewise, a school-based cluster-randomized study in Ecuador observed a strong association between total IgE and STH infection but not with age, nutritional, or socioeconomic status, suggesting that STH infection is an important determinant of total IgE [30].…”

Section: Discussionsupporting

confidence: 82%

Prevalence of Atopy following Mass Drug Administration with Albendazole: A Study in School Children on Flores Island, Indonesia

Staal

Hogendoorn

Voets

et al. 2018

Int Arch Allergy Immunol

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Background: In many rural areas of tropical countries such as Indonesia, the prevalence of soil-transmitted helminths (STH) infections remains high. At the same time, the burden of allergic disorders in such rural areas is reported to be low and inversely associated with helminth infections. To reduce the morbidity and transmission of helminth infections, the world health organization recommends preventive treatment of school children by providing mass drug administration (MDA) with albendazole. Here, we had an opportunity to evaluate the prevalence of skin reactivity to allergens before and after albendazole treatment to get an indication of the possible impact of MDA on allergic sensitization. Methods: A study was conducted among 150 school children living in an area endemic for STH infections. Before and 1 year after anthelminthic treatment with albendazole, stool samples were examined for the presence of STH eggs, skin prick tests (SPT) for cockroach and house dust mites were performed, blood eosinophilia was assessed, and total immunoglobulin E (IgE) and C-reactive protein (CRP) were measured in plasma. Results: Anthelminthic treatment significantly reduced the prevalence of STH from 19.6 before treatment to 6% after treatment (p < 0.001). Levels of total IgE (estimate: 0.30; 95% CI 0.22–0.42, p < 0.0001), CRP (estimate: 0.60; 95% CI 0.42–0.86, p = 0.006), and eosinophil counts (estimate: 0.70; 95% CI 0.61–0.80, p < 0.001) decreased significantly. The prevalence of SPT positivity increased from 18.7 to 32.7%. Multivariate analysis adjusted for confounding factors showed an increased risk of being SPT positive to any allergen (OR 3.04; 95% CI 1.338–6.919, p = 0.008). Conclusions: This study indicates that 1 year of MDA with albendazole was associated with a reduced prevalence of STH infections. This study shows that the prevalence of allergic sensitization increases after 1 year of albendazole treatment. Placebo-controlled and larger studies are needed to further substantiate a role of deworming treatment in an increased risk of allergic sensitization.

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Section: Discussionsupporting

confidence: 82%

Prevalence of Atopy following Mass Drug Administration with Albendazole: A Study in School Children on Flores Island, Indonesia

Staal

Hogendoorn

Voets

et al. 2018

Int Arch Allergy Immunol

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“…In epidemiological studies, low SES has been associated with poorer hygiene practices which in turn could increase exposure to other microorganism or parasites . Infections with parasitic helminths are known to induce a strong Th‐2 immune response that can lead to elevated levels of IgE . In the current study, we found no statistically significant differences in the prevalence of current helminth infections between mothers with low and high SES; however, the levels of tIgE in mothers/newborns with low SES were significantly higher than mothers/newborns with high SES.…”

Section: Discussioncontrasting

confidence: 70%

BCG scar, socioeconomic and nutritional status: a study of newborns in urban area of Makassar, Indonesia

Amaruddin

Wahyuni

Hamid

et al. 2019

Tropical Med Int Health

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SummaryObjectiveTo investigate factors that determine the response to Bacille Calmette–Guérin (BCG) vaccination in urban environments with respect to socioeconomic status (SES), prenatal exposure to infections or newborn's nutritional status.MethodsThe study was conducted in an urban area, in Makassar, Indonesia. At baseline, 100 mother and newborns pair from high and low SES communities were included. Intestinal protozoa, soil transmitted helminths, total IgE, anti‐Hepatitis A Virus IgG and anti‐Toxoplasma IgG were measured to determine exposure to infections. Information on gestational age, birth weight/height and delivery status were collected. Weight‐for‐length z‐score, a proxy for newborns adiposity, was calculated. Leptin and adiponectin from cord sera were also measured. At 10 months of age, BCG scar size was measured from 59 infants. Statistical modelling was performed using multiple linear regression.ResultsBoth SES and birth nutritional status shape the response towards BCG vaccination at 10 months of age. Infants born to low SES families have smaller BCG scar size compared to infants born from high SES families and total IgE contributed to the reduced scar size. On the other hand, infants born with better nutritional status were found to have bigger BCG scar size but this association was abolished by leptin levels at birth.ConclusionThis study provides new insights into the importance of SES and leptin levels at birth on the development of BCG scar in 10 months old infants.

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“…All children were offered treatment after the initial trial, and therefore potentially all of these children received treatment for deworming. Appraised in a separate systematic review by Jullien 2016 and classified as high risk of bias and excluded.de Ruiter 2017No relevant outcomes.Diouf 2002Intervention comprised mebendazole, vitamin A, and iron supplementation and metronidazole as a combined intervention versus placebo.Evans 1986Treatments randomized, but some placebo groups accessed treatment. Analysis was by the treatment received, and randomization was ignored (included in the Dickson 2000a Cochrane Review).Fernando 1983Two villages allocated to treatment or no treatment on the basis of a coin toss.…”

Section: Characteristics Of Excluded Studies [Ordered By Study Id]mentioning

confidence: 99%

Public health deworming programmes for soil-transmitted helminths in children living in endemic areas

Taylor-Robinson

Maayan

Donegan

et al. 2019

Cochrane Database of Systematic Reviews

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Background The World Health Organization (WHO) recommends treating all school children at regular intervals with deworming drugs in areas where helminth infection is common. Global advocacy organizations claim routine deworming has substantive health and societal effects beyond the removal of worms. In this update of the 2015 edition we included six new trials, additional data from included trials, and addressed comments and criticisms. Objectives To summarize the effects of public health programmes to regularly treat all children with deworming drugs on child growth, haemoglobin, cognition, school attendance, school performance, physical fitness, and mortality. Search methods We searched the Cochrane Infectious Diseases Group Specialized Register; Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE; Embase; LILACS; the meta Register of Controlled Trials ( m RCT); reference lists; and registers of ongoing and completed trials up to 19 September 2018. Selection criteria We included randomized controlled trials (RCTs) and quasi‐RCTs that compared deworming drugs for soil‐transmitted helminths (STHs) with placebo or no treatment in children aged 16 years or less, reporting on weight, height, haemoglobin, and formal tests of cognition. We also sought data on other measures of growth, school attendance, school performance, physical fitness, and mortality. Data collection and analysis At least two review authors independently assessed the trials for inclusion, risk of bias, and extracted data. We analysed continuous data using the mean difference (MD) with 95% confidence intervals (CIs). Where data were missing, we contacted trial authors. We stratified the analysis based on the background burden of STH infection. We used outcomes at time of longest follow‐up. We assessed the certainty of the evidence using the GRADE approach. Main results We identified 51 trials, including 10 cluster‐RCTs, that met the inclusion criteria. One trial evaluating mortality included over one million children, and the remaining 50 trials included a total of 84,336 participants. Twenty‐four trials were in populations categorized as high burden, including nine trials in children selected because they were helminth‐stool positive; 18 with intermediate burden; and nine as low burden. First or single dose of deworming drugs Fourteen trials reported on weight after a single dose of deworming drugs (4970 participants, 14 RCTs). The effects were variable. There was little or no effect in studies conducted in low and intermediate worm burden groups. In the high‐burden group, there was little or no effect in most studies, except for a large effect detected from one study area in Kenya reported in two trials carried out over 30 years ago. These trials result in qualitative hete...

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The effect of three‐monthly albendazole treatment on Th2 responses: Differential effects on IgE and IL‐5

Cited by 8 publications

References 27 publications

Prevalence of Atopy following Mass Drug Administration with Albendazole: A Study in School Children on Flores Island, Indonesia

Prevalence of Atopy following Mass Drug Administration with Albendazole: A Study in School Children on Flores Island, Indonesia

BCG scar, socioeconomic and nutritional status: a study of newborns in urban area of Makassar, Indonesia

Public health deworming programmes for soil-transmitted helminths in children living in endemic areas

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