Short repeats in the heme oxygenase 1 gene promoter is associated with increased levels of inflammation, ferritin and higher risk of type-2 diabetes mellitus

Andrews, Mónica; Leiva, Elba; Arredondo, Miguel

doi:10.1016/j.jtemb.2016.06.001

Cited by 12 publications

(11 citation statements)

References 31 publications

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“…In retrospective analysis, T(−413)A single nucleotide polymorphism (SNP) of Heme oxygenase 1 (HMOX1) promoter was significantly more susceptible to albuminuria development than those carrying the A allele, especially in T2DM with longer duration and poor glycemic control 41–43. Yin et al, investigate that blocking of George et al, suggested that the role of Akt deficiency in human type 2 diabetes was underscored by the discovery of a family with type 2 diabetes associated with an inherited loss of function Akt2 mutation that seems to act in a dominant-negative manner to inhibit other Akt isoforms 44.…”

Section: Resultsmentioning

confidence: 99%

<p>A Network Pharmacology-Based Strategy For Predicting Active Ingredients And Potential Targets Of LiuWei DiHuang Pill In Treating Type 2 Diabetes Mellitus</p>

He¹,

Huang²,

Zhang³

et al. 2019

DDDT

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BackgroundTraditional Chinese medicine (TCM) formulations have proven to be advantageous in clinical treatment and prevention of disease. LiuWei DiHuang Pill (LWDH Pill) is a TCM that was employed to treat type 2 diabetes mellitus (T2DM). However, a holistic network pharmacology approach to understanding the active ingredients and the therapeutic mechanisms underlying T2DM has not been pursued.MethodsA network pharmacology approach including drug-likeness evaluation, oral bioavailability prediction, virtual docking, and network analysis has been used to predict the active ingredients and potential targets of LWDH Pill in the treatment of type 2 diabetes.ResultsThe comprehensive network pharmacology approach was successfully to identify 45 active ingredients in LWDH Pill. 45 active ingredients hit by 163 potential targets related to T2DM. Ten of the more highly predictive components (such as :quercetin, Kaempferol, Stigmasterol, beta-sitosterol, Kadsurenone, Diosgenin, hancinone C, Hederagenin, Garcinone B, Isofucosterol) are involved in anti-inflammatory, anti-oxidative stress, and the reduction of beta cell damage. LWDH Pill may play a role in the treatment of T2DM and its complications (atherosclerosis and nephropathy) through the AGE-RAGE signaling pathway, TNF signaling pathway, and NF-kappa B signaling pathway.ConclusionBased on a systematic network pharmacology approach, our works successfully predict the active ingredients and potential targets of LWDH Pill for application to T2DM and helps to illustrate mechanism of action on a comprehensive level. This study provides identify key genes and pathway associated with the prognosis and pathogenesis of T2DM from new insights, which also demonstrates a feasible method for the research of chemical basis and pharmacology in LWDH Pill.

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Section: Resultsmentioning

confidence: 99%

<p>A Network Pharmacology-Based Strategy For Predicting Active Ingredients And Potential Targets Of LiuWei DiHuang Pill In Treating Type 2 Diabetes Mellitus</p>

He¹,

Huang²,

Zhang³

et al. 2019

DDDT

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“…These data show that overexpression of HO-1 protects renal cells from oxidative stress [32,33]. A recent study on 835 patients showed that the SM (short repeat) genotype of the (GT)n microsatellite polymorphism in the HO1 gene promoter and ferritin levels was associated with higher risk for type 2 diabetes [34]. A length polymorphism of GT repeats in the promoter of human HO-1 gene has been shown to modulate gene transcription, and this length polymorphism in the HO-1 gene promoter correlated in a Chinese trial with the susceptibility to coronary artery disease in diabetic patients [35].…”

Section: Heme Oxygenase-1mentioning

confidence: 73%

Genetic Polymorphisms of Antioxidant and Antiglycation Enzymes and Diabetic Complications. How Much Can we Learn from the Genes?

Oikonomou

Groener

Cheko

et al. 2017

Exp Clin Endocrinol Diabetes

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There is growing evidence that reactive metabolites, such as reactive oxygen species and dicarbonyls contribute to diabetic complications. Formation, accumulation, and detoxification of these metabolites are controlled by several enzymes, some of which have genetically determined levels of expression or function. This review not only gives an overview of the different SNPs studied in patients with diabetes mellitus type 1 and type 2, but in addition attempts to bridge the gap between a genetic study and clinical use. Therefore, not only the results of the studies are reviewed, but also their use in identification of subgroups where an increased or decreased risk for a diabetic complication is described, as well as their use in developing novel therapeutic options based on understanding the contribution of an enzyme to a given complication.

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“…Furthermore, the authors found that elevated CRP levels could be regarded as an indicator of metabolic syndrome. Another study associated ferritin levels with the risk of developing type 2 DM and elevated levels of the markers of inflammation 21. Increased serum ferritin and CRP levels are a primary risk factor for the development of chronic diseases.…”

Section: Discussionmentioning

confidence: 99%

Influence of ferritin levels and inflammatory markers on HbA1c in the Type 2 Diabetes mellitus patients

Son¹

2019

Pak J Med Sci

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Objective: Diabetes Mellitus (DM) is a significant public health issue worldwide due to the associated comorbidities. Recent studies have demonstrated a strong relationship between blood glucose levels and serum ferritin levels in patients with type 2 DM. The aim of the study was to investigate the association between Ferritin Levels and Inflammatory Markers on HbA1c in the Type 2 Diabetes Mellitus Patients. Methods: This single-center, cross-sectional, controlled study included patients who were admitted to the Endocrine and Metabolic Disorders outpatient clinics of the Private Kütahya Hospital in the province of Kutahya in the Western Turkey. The study included a total of 172 patients, 84 of whom had type 2 DM and 88 without diabetes and constituted the control group. A total of 190 patients with DM were admitted to the Adult Endocrine and Metabolic Diseases Outpatient Clinics of the hospital between July 1, 2018 and September 1, 2018, and among these, the study was conducted on 172 volunteer patients who met the study inclusion criteria and who did not have any missing data. The HbA1c levels, serum ferritin, hemoglobin (Hb), insulin, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), C-Reactive Protein (CRP), lipid profiles, and uric acid levels were compared between the groups. Results: The serum ferritin levels of the patients with type 2 DM significantly increased with increasing HbA1c levels (p<0.01). A strong positive correlation was found between serum ferritin levels and HbA1c and fasting blood glucose (FBG) levels (p<0.01). Conclusions: Our study results show a significant relationship between HbA1c levels and serum ferritin and CRP levels, suggesting that serum ferritin and CRP levels can be used as a routine screening tool for the early diagnosis of DM. However, further large-scale, prospective studies are needed to confirm these findings. doi: https://doi.org/10.12669/pjms.35.4.1003 How to cite this:Son NE. Influence of ferritin levels and inflammatory markers on HbA1c in the Type 2 Diabetes mellitus patients. Pak J Med Sci. 2019;35(4):---------. doi: https://doi.org/10.12669/pjms.35.4.1003 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Short repeats in the heme oxygenase 1 gene promoter is associated with increased levels of inflammation, ferritin and higher risk of type-2 diabetes mellitus

Cited by 12 publications

References 31 publications

<p>A Network Pharmacology-Based Strategy For Predicting Active Ingredients And Potential Targets Of LiuWei DiHuang Pill In Treating Type 2 Diabetes Mellitus</p>

<p>A Network Pharmacology-Based Strategy For Predicting Active Ingredients And Potential Targets Of LiuWei DiHuang Pill In Treating Type 2 Diabetes Mellitus</p>

Genetic Polymorphisms of Antioxidant and Antiglycation Enzymes and Diabetic Complications. How Much Can we Learn from the Genes?

Influence of ferritin levels and inflammatory markers on HbA1c in the Type 2 Diabetes mellitus patients

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