Short Physical Performance Battery and Incident Cardiovascular Events Among Older Women

Bellettiere, John; LaMonte, Michael J.; Unkart, Jonathan T.; Liles, Sandy; Laddu-Patel, Deepika; Manson, JoAnn E.; Banack, Hailey R.; Seguin‐Fowler, Rebecca A.; Chavez, Paul; Tinker, Lesley F.; Wallace, Robert B.; LaCroix, Andrea Z.

doi:10.1161/jaha.120.016845

Cited by 31 publications

(20 citation statements)

References 44 publications

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“…Moreover, the decline in physical function related to aging often leads to loss of independence and ability to perform activities of daily life, as well as poorer quality of life [ 17 ]. Poor physical function is associated with increased risk of outcomes such as cognitive impairment, institutionalization, falls [ 18 ], disability [ 7 ], cardiovascular events [ 19 ], and mortality [ 7 , 20 ]. Therefore, elderly people on KRT should receive greater attention from their health care team and interventions should be proposed.…”

Section: Discussionmentioning

confidence: 99%

Age, diabetes mellitus, and dialysis modality are associated with risk of poor muscle strength and physical function in hemodialysis and peritoneal dialysis patients

Silva

Antônio

Reis

et al. 2021

Kidney Res Clin Pract

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Background: Due to the poor outcomes associated with the impairment of physical function and muscle strength in patients on maintenance dialysis, it is important to understand the factors that may influence physical function and muscle strength. The aim of this study was to explore the factors associated with physical function in hemodialysis and peritoneal dialysis patients. Methods: Patients with chronic kidney disease on dialysis for at least 3 months, aged 18 years old or above, were enrolled. Physical function was assessed by handgrip strength, gait and sit-to-stand tests, and the Short Physical Performance Battery (SPPB). Clinical and laboratory data were collected to verify the association with physical function parameters through binary logistic regression. Results: One-hundred ninety patients on maintenance dialysis were included; 140 patients (73.7%) on hemodialysis and 50 (26.3%) on peritoneal dialysis. The mean age was 57.3 ± 14.9 years, 109 (57.4%) were male, and 87 (45.8%) were older than 60 years. The median SPPB was 8.0 points (6.0-10.0 points) and the mean ± standard deviation of handgrip strength was 24.7 ± 12.2 kg. Binary logistic regression showed that age, type of renal replacement therapy, diabetes mellitus, and serum creatinine were significantly associated with both higher 4-meter gait test times and lower SPPB scores. Only age and diabetes mellitus were associated with higher sit-to-stand test times, while age and ferritin were associated with lower handgrip strength. Conclusion: Age, diabetes mellitus, serum creatinine, and hemodialysis modality are factors related to physical function in dialysis patients.

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Section: Discussionmentioning

confidence: 99%

Age, diabetes mellitus, and dialysis modality are associated with risk of poor muscle strength and physical function in hemodialysis and peritoneal dialysis patients

Silva

Antônio

Reis

et al. 2021

Kidney Res Clin Pract

View full text Add to dashboard Cite

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“…Previous studies have evaluated the association of SPPB and mortality and shown SPPB score is an independent predictor of all‐cause mortality among patients discharged from acute care hospitals 40 . Further studies by Bellettiere et al reported strong linear inverse associations between SPPB and incident CVD 41 . In the Health ABC cohort, worse performance on a physical function assessment battery was associated with a higher risk for HF 35 .…”

Section: Discussionmentioning

confidence: 99%

Prefrailty, impairment in physical function, and risk of incident heart failure among older adults

Segar

Singh

Goyal

et al. 2021

J American Geriatrics Society

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Objective Evaluate the association between prefrailty and the risk of heart failure (HF) among older adults. Design, setting, and participants This prospective, community‐based cohort study included participants from the Atherosclerotic Risk in Communities study who underwent detailed frailty assessment using Fried Criteria and physical function assessment using the Short Performance Physical Battery (SPPB) score. Individuals with prevalent HF and frailty were excluded. Main outcomes and measures Adjusted association between prefrailty (vs robust), physical function measures (SPPB score, grip strength, and gait speed), and incident HF (overall and HF subtypes, HF with reduced [HFrEF, EF < 50%] and preserved ejection fraction [HFpEF]) were assessed using Cox proportional hazards models. Results Among 5210 participants (mean age 75 years, 58% women), 2565 (49.2%) were identified as prefrail. In cross‐sectional analysis, prefrail individuals had a higher burden of chronic myocardial injury (troponin, Std β = 0.08 [0.05–0.10]) and neurohormonal stress (NT‐ProBNP, Std β = 0.03 [0.02–0.05]) after adjustment for potential confounders. Over a median follow‐up of 4.6 years, there were 232 (4.5%) HF events (HFrEF: 102; HFpEF: 97). Prefrailty was associated with an increased risk of HF after adjusting for potential clinical confounders and cardiac biomarkers (aHR [95% CI] = 1.65 [1.24–2.20]). Among HF subtypes, prefrailty was associated with an increased risk of HFpEF but not HFrEF (aHR [95% CI] = 1.73 [1.11–2.70] and 1.38 [0.90–2.10], respectively). A lower SPPB score was also associated with an increased risk of overall HF and HFpEF, but not HFrEF. Among individual components, increased gait speed were associated with a lower risk of HFpEF, but not HFrEF. Conclusions and relevance Subtle abnormalities in physiological reserve (prefrailty) and impairment in physical function (SPPB) were both significantly associated with a higher risk of incident HF, particularly HFpEF. These findings highlight the potential role of routine assessment of geriatric syndromes for early identification of HF risk.

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“…11 Physical performance, including upper and lower extremity functions, declines gradually with age, and poor physical performance in the elderly is strongly associated with adverse health outcomes such as CVD and mortality. [12][13][14] Notably, different types of physical performance have different effects on cardiovascular function. Lower extremity function assists the heart in pumping blood, while upper extremity function is closely related to endothelial function.…”

Section: Open Accessmentioning

confidence: 99%

“…Cohort studies have observed a significant inverse linear doseresponse relationship between SPPB total score and CVD. 12 UK Biobank research suggests that adding grip strength to existing risk scores improved the prediction of CVD. 13 However, our study indicated that SPPB total score rather than grip strength was associated with CVD risk.…”

Section: Physical Performance Night Sleep Duration and Cvd Riskmentioning

confidence: 99%

Mediating effects of lower extremity function on the relationship between night sleep duration and cardiovascular disease risk: a cross-sectional study in elderly Chinese without cardiovascular diseases

et al. 2021

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ObjectiveThe purpose of this study is to investigate the mediating effect of physical performance on the relationship between night sleep duration and risk of cardiovascular disease (CVD) in elderly Chinese without CVD.Methods782 participants without CVD over 65 years (average: 70.82±3.86 years, 448 women) were included in this study. CVD risk was calculated by the Framingham Risk Score and participants were divided into four groups of night sleep duration (in hours): <7 hours, ≥7–8 hours, >8–9 hours and >9 hours. Upper extremity function was measured by grip strength and lower extremity function was measured by the Short Physical Performance Battery (SPPB), consisting of balance, 4 m walk and chair stands tests.ResultsAfter adjusting for covariates, long night sleep duration (>9 hours) and CVD risk were significantly positively associated compared with moderate night sleep duration (≥7–8 hours) (β=1.152; 95% CI 0.05 to 2.25). SPPB total score (indirect effect ab=−0.122; 95% CI −0.291 to –0.0008) rather than grip strength partially mediated the relationship between long night sleep duration and CVD risk, in which chair stands played a major mediating role (indirect effect ab=−0.171; 95% CI −0.040 to –0.0006), while balance (indirect effect ab=−0.016; 95% CI −0.100 to 0.063) and 4 m walk (indirect effect ab=0.048; 95% CI −0.066 to 0.201) did not.ConclusionsLower extremity function, especially lower limb muscle strength, partially mediates a positive association between long night sleep duration and CVD risk in the elderly without CVD. Suitable interventions for physical performance and sleep may minimise the risk of subsequent CVD.

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Short Physical Performance Battery and Incident Cardiovascular Events Among Older Women

Cited by 31 publications

References 44 publications

Age, diabetes mellitus, and dialysis modality are associated with risk of poor muscle strength and physical function in hemodialysis and peritoneal dialysis patients

Age, diabetes mellitus, and dialysis modality are associated with risk of poor muscle strength and physical function in hemodialysis and peritoneal dialysis patients

Prefrailty, impairment in physical function, and risk of incident heart failure among older adults

Mediating effects of lower extremity function on the relationship between night sleep duration and cardiovascular disease risk: a cross-sectional study in elderly Chinese without cardiovascular diseases

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