Short, fine and WHO asbestos fibers in the lungs of quebec workers with an asbestos‐related disease

Adib, Georges; Guire, Louise De; Dion, Chantal; Dufresne, A.

doi:10.1002/ajim.22180

Cited by 24 publications

(19 citation statements)

References 34 publications

(75 reference statements)

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“…Nevertheless, asbestos bodies were easily detectable in the lung dust analyses and histological evaluations (Figure 3a). This fact is confirmed by other authors [25][26][27] and in other studies [28]. Asbestos fibers, including chrysotile/white asbesbeen diagnosed as a bridge finding for BK 4104, recognition as an occupational disease had been recommended and this would not have been possible without the quite demanding lung dust analysis and histological examination applying iron staining.…”

Section: Discussionsupporting

confidence: 61%

Histological findings and lung dust analysis as the basis for occupational disease compensation in asbestos-related lung cancer in Germany

Feder

Theile

Tannapfel

2017

Int J Occup Med Environ Health

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Objectives: This study has researched the significance of histologically raised findings and lung dust analyses in the context of claiming the recognition of and thus compensation for an asbestos-associated occupational disease. Material and Methods: For this approach, all findings from the German Mesothelioma Register in 2015 that included lung dust analyses were evaluated and were compared with information on asbestos fiber exposure at work based on fiber years, and with the results of radiological findings. Results: For 68 insured persons, recognition of an asbestos-induced lung disease according to Section 4104 of the German Ordinance on Occupational Diseases (Berufskrankheitenverordnung -BKV) could be recommended solely on the basis of the histological examinations of lung tissues and complementary lung dust analyses. Neither did the calculation of the cumulative asbestos dust exposure at work yield 25 fiber years, nor could bridge findings (e.g., plaques) be identified. In addition, the autopsies of 12 patients revealed plaques that had not been diagnosed during radiological examinations. These results show that -irrespective of the prescribed working techniques and radiological diagnosis -pathological/anatomical and histological diagnostics are often the only way for the insureds to demonstrate the causal connection between asbestos and their disease. Even after long intervals of up to 40 years post last exposure, the asbestos fibers would still be easily detectable in the lung tissues evaluated. Conclusions: Whenever suitable tissue is available, it should be examined for mild asbestosis with the aid of a lung dust analysis. Otherwise there is a risk that an occupational disease is wrongfully rejected. In the context of health insurance, the lung dust analysis and the resulting proof of the presence of asbestosis often constitute one option of providing evidence of an occupational disease. Int J Occup Med Environ Health 2018;31(3):293 -305

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Section: Discussionsupporting

confidence: 61%

Histological findings and lung dust analysis as the basis for occupational disease compensation in asbestos-related lung cancer in Germany

Feder

Theile

Tannapfel

2017

Int J Occup Med Environ Health

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“…Adib and colleagues analysed the fibres detected in lung tissue obtained from workers in Quebec whose disease was recognised as asbestos-related. The results showed that half of the asbestos fibres found in the lung tissues of workers were short (<5 µm) and the aspect ratios of the tremolite fibres were always <20:1 49. Some may suppose that short fibres are generated from the disintegration of long fibres; however, in an animal study conducted by Pott and colleagues, chrysotile asbestos was milled into short fibres, such that nearly 100% of the fibres were shorter than 5 µm, and were intraperitoneally injected into Wistar rats.…”

Section: Discussionmentioning

confidence: 97%

Cancer mortality in a population exposed to nephrite processing

Yang¹,

Huang

Shie

et al. 2016

Occup Environ Med

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“…Even many years after the last exposure, asbestos fibres can be found in the lungs of asbestos worker. In a study of workers in Quebec, Canada, based on data collected between 1988-2007, even 30 years or more after the last exposure, chrysotile fibres were found in worker's lungs [29]. In North Carolina, USA, more than half of hospitalizations concerned persons aged 65-84 years [3].…”

Section: Discussionmentioning

confidence: 99%

Asbestosis hospitalizations in Poland (2006–2016): results from the National Hospital Discharge Registry

Kanecki

Kosińska

Tyszko

et al. 2020

Ann Agric Environ Med.

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Introduction and objective. Occupational asbestos exposure is one of the major public health issues. Although asbestos use in Poland has decreased, asbestosis continues to remain an important health concern in the area of occupational medicine. The aim of the study is to perform a descriptive analysis of hospitalization cases in patients suffering from asbestosis in Poland. Materials and method. The authors used hospital discharge records to conduct a retrospective, population-based study. To estimate the asbestosis hospitalization rate, data from the Nationwide General Hospital Morbidity Study conducted by the National Institute of Public Health were used. Events were defined as in-patient hospital discharges during 2006-2016. 1,101 hospitalization records of 764 patients were included in the study. Results. In the study group of first-time hospitalized patients, the mean and median ages were 68.1 and 69 years, respectively; CI: 67.3-68.9; SD: 11.1, min-max:16-99 years. In this group, significant gender differences were observed (560 males vs. 204 female; P<0.001). No statistical differences were observed regarding the place of residence. During the observation period, 61 in-hospital deaths were reported (8% of all patients), 40 of whom (5.2 % of all patients) took place during the first-time hospitalizations. Asbestosis hospitalizations were mainly clustered in the southwestern region, whereas the highest hospitalization rates were clustered in several areas of Poland. Conclusions. The authors believe this study to be the first evaluation of asbestosis in Poland made on the basis of the hospital morbidity database. The data presented may be helpful in comparative studies on the epidemiology of asbestosis across European countries.

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Short, fine and WHO asbestos fibers in the lungs of quebec workers with an asbestos‐related disease

Abstract: Our findings stress the relevance of considering several dimensional criteria to characterize health risks associated with asbestos inhalation.

Cited by 24 publications

References 34 publications

Histological findings and lung dust analysis as the basis for occupational disease compensation in asbestos-related lung cancer in Germany

Histological findings and lung dust analysis as the basis for occupational disease compensation in asbestos-related lung cancer in Germany

Cancer mortality in a population exposed to nephrite processing

Asbestosis hospitalizations in Poland (2006–2016): results from the National Hospital Discharge Registry

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