Short exposure to a diet rich in both fat and sugar or sugar alone impairs place, but not object recognition memory in rats

Beilharz, Jessica E.; Maniam, Jayanthi; Morris, Margaret J.

doi:10.1016/j.bbi.2013.11.016

Cited by 194 publications

(167 citation statements)

References 36 publications

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“…In contrast, these markers were not significantly elevated in rats that received the cafeteria diet without added sucrose. Hippocampal BDNF mRNA was similar across all groups (30), which confirms the current results.…”

Section: Discussionsupporting

confidence: 80%

High Fat Diet- Induced Neurotoxicity Alters Following vitamin E and C Administration in Hippocampus of Male Rats

et al. 2017

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Background: Consumption of a high fat diet (HFD) leads to spatial memory impairment and hippocampal cell death. Objectives: The present study evaluated the capacity of antioxidant supplementation to interact with the effects of high fat diet at the molecular level. Methods: Animal groups were exposed to HFD for 9 months with free access to high fat diet and high fat diet with antioxidant supplementation (vitamin E, vitamin C, and Astaxanthin). At the end of the study, brains were removed and the level of brain-derived

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Section: Discussionsupporting

confidence: 80%

High Fat Diet- Induced Neurotoxicity Alters Following vitamin E and C Administration in Hippocampus of Male Rats

et al. 2017

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“…[7][8][9][10] Studies performed in animal models of diet-induced obesity and InsRes such as longterm HFFD feeding show a deficient execution in memory and learning tasks. [11][12][13][14][15][16] These cognitive alterations were associated with functional and structural changes in the hippocampus, such as reduced number and complexity of dendritic spines in the CA1 subfield, altered establishment of long-term potentiation and long-term depression, and diminished dentate gyrus (DG) neurogenesis. [11][12][13] The latter was correlated with decreased expression of brain derived neurotrophic factor, cyclic AMP-response element-binding protein and the synaptic proteins synapsin, and stargazin.…”

Section: Introductionmentioning

confidence: 99%

“…[11][12][13][14][15][16] These cognitive alterations were associated with functional and structural changes in the hippocampus, such as reduced number and complexity of dendritic spines in the CA1 subfield, altered establishment of long-term potentiation and long-term depression, and diminished dentate gyrus (DG) neurogenesis. [11][12][13] The latter was correlated with decreased expression of brain derived neurotrophic factor, cyclic AMP-response element-binding protein and the synaptic proteins synapsin, and stargazin. 11 It has been extensively shown that insulin has a pivotal role in hippocampal neuronal function as a metabolic, growth, synaptic, and survival modulator.…”

Section: Introductionmentioning

confidence: 99%

Short-Term High-Fat-and-Fructose Feeding Produces Insulin Signaling Alterations Accompanied by Neurite and Synaptic Reduction and Astroglial Activation in the Rat Hippocampus

Calvo-Ochoa

Hernández‐Ortega

Ferrera

et al. 2014

J Cereb Blood Flow Metab

123

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Chronic consumption of high-fat-and-fructose diets (HFFD) is associated with the development of insulin resistance (InsRes) and obesity. Systemic insulin resistance resulting from long-term HFFD feeding has detrimental consequences on cognitive performance, neurogenesis, and long-term potentiation establishment, accompanied by neuronal alterations in the hippocampus. However, diet-induced hippocampal InsRes has not been reported. Therefore, we investigated whether short-term HFFD feeding produced hippocampal insulin signaling alterations associated with neuronal changes in the hippocampus. Rats were fed with a control diet or an HFFD consisting of 10% lard supplemented chow and 20% high-fructose syrup in the drinking water. Our results show that 7 days of HFFD feeding induce obesity and InsRes, associated with the following alterations in the hippocampus: (1) a decreased insulin signaling; (2) a decreased hippocampal weight; (3) a reduction in dendritic arborization in CA1 and microtubule-associated protein 2 (MAP-2) levels; (4) a decreased dendritic spine number in CA1 and synaptophysin content, along with an increase in tau phosphorylation; and finally, (5) an increase in reactive astrocyte associated with microglial changes. To our knowledge, this is the first report addressing hippocampal insulin signaling, as well as morphologic, structural, and functional modifications due to short-term HFFD feeding in the rat.

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“…Hippocampal-dependent forms of learning and memory are particularly vulnerable to the detrimental effects of the overconsumption of high fat and high sugar diets (Molteni et al 2002;Beilharz et al 2014;Hsu et al 2015;Reichelt et al 2015a,b;Abbott et al 2016). Furthermore, these detrimental effects can be long lasting.…”

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confidence: 99%

“…Continuous consumption of sucrose for 4 wk decreased neurogenesis measured by reduced BrdU immunoreactive cells in the DG (van der Borght et al 2011), however this more direct assay of neurogenesis was not measured in the current study. Neuroinflammation is another likely candidate as it inhibits neurogenesis (Monje et al 2003), and high sugar diets increase levels of pro-inflammatory cytokines in the hippocampus (van der Borght et al 2011;Beilharz et al 2014;Hsu et al 2015). Despite consuming similar amounts of energy overall as control rats, the rats that consumed sucrose had increased adiposity.…”

mentioning

confidence: 99%

Daily access to sucrose impairs aspects of spatial memory tasks reliant on pattern separation and neural proliferation in rats

2016

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High sugar diets reduce hippocampal neurogenesis, which is required for minimizing interference between memories, a process that involves "pattern separation." We provided rats with 2 h daily access to a sucrose solution for 28 d and assessed their performance on a spatial memory task. Sucrose consuming rats discriminated between objects in novel and familiar locations when there was a large spatial separation between the objects, but not when the separation was smaller. Neuroproliferation markers in the dentate gyrus of the sucrose-consuming rats were reduced relative to controls. Thus, sucrose consumption impaired aspects of spatial memory and reduced hippocampal neuroproliferation.

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Short exposure to a diet rich in both fat and sugar or sugar alone impairs place, but not object recognition memory in rats

Cited by 194 publications

References 36 publications

High Fat Diet- Induced Neurotoxicity Alters Following vitamin E and C Administration in Hippocampus of Male Rats

High Fat Diet- Induced Neurotoxicity Alters Following vitamin E and C Administration in Hippocampus of Male Rats

Short-Term High-Fat-and-Fructose Feeding Produces Insulin Signaling Alterations Accompanied by Neurite and Synaptic Reduction and Astroglial Activation in the Rat Hippocampus

Daily access to sucrose impairs aspects of spatial memory tasks reliant on pattern separation and neural proliferation in rats

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