Short-course postpartum (6-h) magnesium sulfate therapy in severe preeclampsia

Anjum, Shaheen; Rajaram, G; Bano, Imam

doi:10.1007/s00404-015-3903-y

Cited by 11 publications

(8 citation statements)

References 4 publications

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“…“HELLP syndrome” is a variant of severe pre-eclampsia that is characterized by hemolysis, elevated liver enzymes, and low platelets. Hepatic failure, liver rupture, renal dysfunction or irreversible renal failure secondary to renal cortical necrosis has also been reported [ 15 ]. As defined in ACOG guideline, the gestational hypertension is ‘BP elevation after 20 weeks of gestation in the absence of proteinuria or the aforementioned systemic findings [ 13 ].…”

Section: Methodsmentioning

confidence: 99%

Elective delivery versus expectant management for pre-eclampsia: a meta-analysis of RCTs

Wang

Hao

Sampson³

et al. 2017

Arch Gynecol Obstet

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PurposeTo evaluate the effectiveness and safety of elective delivery versus expectant management for women with pre-eclampsia (PE) and to assess neonatal outcomes before and after 34 weeks gestation.MethodsWe searched Biomed Central, CINAHL, Cochrane Library, Embase, HMIC, Medline, and WHO trial registry, British Nursing Index, ClinicalTrials.gov, Current Controlled Trials, and Web of Science on 16 March, 2016. 1704 citations were identified. Randomised controlled trials comparing elective delivery with expectant management for women with PE were included. Seven studies were included (n = 1501). There were no maternal deaths.ResultsElective delivery lowered incidence of complications in women with PE or hypertension greater than 34 weeks gestation (n = 756; RR, 0.64; 95% CI 0.51–0.80). For women with severe PE less than 34 weeks gestation, elective delivery lowered the incidence of placental abruption (n = 483, 5 RCTs; RR, 0.43; 95% CI 0.19–0.98). For women with PE or hypertension greater than 34 weeks gestation, elective delivery also reduced the need for antihypertensive drug therapy. The need for ventilatory support and the risk of developing neonatal intraventricular hemorrhage or hypoxic ischemic encephalopathy may be increased in infants whose mothers undergo elective delivery for severe PE at less than 34 weeks gestation. However, there was no relevant evidence for women with severe PE over 34 weeks.ConclusionsIn women with PE or gestational hypertension beyond 34 weeks gestation, elective delivery can decrease the incidence of complications, severe hypertension and the need for antihypertensive drug therapy. Elective delivery can also lower the risk of placental abruption in women before 34 weeks gestation with severe PE, however, may be associated with increased risk of neonatal complications.

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Section: Methodsmentioning

confidence: 99%

Elective delivery versus expectant management for pre-eclampsia: a meta-analysis of RCTs

Wang

Hao

Sampson³

et al. 2017

Arch Gynecol Obstet

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“…12,13 Duration of hospital stay was reduced in all reported (four) studies with shorter-duration magnesium sulphate. 6,9,15,16 Flushing was reported in only one study, with 12 cases occurring in the shorterduration group compared with the 24-hours group (P5.03). 11 Unauthorized reproduction of this article is prohibited.…”

Section: Resultsmentioning

confidence: 96%

“…Characteristics of included trials are summarized in Table 1. Six studies included a patient population with preeclampsia only, 6,9–13 three studies randomized patients after their first eclamptic seizure, 14–16 and one study included patients with either preeclampsia or eclampsia (Agarwal A, Sharma M, Das V, Pandey A, Agrawal S, Kumar N. Modification of Pritchard regimen of magnesium sulphate for the conditions of a developing country [abstract]. BJOG 2019;126(Suppl 2):150-1).…”

Section: Resultsmentioning

confidence: 99%

Duration of Postpartum Magnesium Sulphate for the Prevention of Eclampsia

Okonkwo

Nash

2022

Obstetrics &Amp; Gynecology

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To estimate the optimal duration of postpartum magnesium sulphate to prevent eclampsia.DATA SOURCES: MEDLINE, EMBASE, CINAHL, the Cochrane Database of Systematic Reviews, and Clinical-Trials.gov databases were searched from inception until January 2020 and limited to English-language human randomized controlled trials. Search strategy included the key works "eclampsia," "magnesium sulphate," and "postpartum."

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“…Two researchers independently evaluated 174 potentially relevant studies. Sixty randomised trials met our inclusion criteria (Figure ) . Thirty‐six trials (60%) evaluated antihypertensive medication, 23 trials (38%) evaluated anticonvulsant medication, and a single trial compared an antihypertensive medication, nimodipine, with an anticonvulsant medication, magnesium sulphate (Table S1).…”

Section: Resultsmentioning

confidence: 99%