Short course chemotherapy for pulmonary tuberculosis

Ormerod, L.P.; McCarthy, O.R.; Rudd, Robin; Horsfield, N.

doi:10.1016/s0954-6111(06)80099-5

Cited by 8 publications

(5 citation statements)

References 9 publications

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“…After the start of treatment, the number of bacilli in the sputum decreases rapidly and in more than 90 percent of cases sputum smears become negative for AFB at 3 months. Studies have also shown that the time for sputum sterilization (indicated by sputum negativity at 2 or 3 months) is an important determinant of relapse [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Correlation of Serum C-Reactive Protein with Disease Severity in Tuberculosis Patients

Shameem¹,

Fatima²,

Ahmad³

et al. 2012

OJRD

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Purpose: To study the factors influencing sputum smear conversion including Serum C-Reactive Protein (CRP) and its correlation with disease severity in tuberculosis patients. Method: Levels of Serum-CRP concentrations were determined in 60 patients with pulmonary tuberculosis, 30 healthy volunteers and patients in follow-up after completion of antitubercular treatment (DOTS therapy). Results: Serum-CRP levels were found to be significantly higher in smear-positive group as compared with the follow-up patients and smear-negative control group. The values were 43.65 ± 23.68, 9.88 ± 5.23 and 4.04 ± 3.85 mg/L respectively (P < 0.0001). Among the smear-positive patients, Serum-CRP levels were the highest in AFB3+ patients (65.28 ± 10.32) as compared with the AFB2+ patients (35.93 ± 7.22), AFB1+ patients (16.37 ± 2.62) and AFB scanty patients (10.92 ± 2.97) respectively, the difference was found statistically significant (P < 0.0001). Correlation of predictors of sputum smear conversion also revealed that these values were significantly higher in active pulmonary tubercular patients as compared to control. It is also found significant positive correlation between AFB smear positive patients with levels of Serum-CRP concentration. Conclusion: Serum-CRP levels are significantly correlated with disease severity in patients with active pulmonary tuberculosis. Thus these findings from the present study would certainly add new criteria for early diagnosis of TB, which may lead to development of new strategies to treat TB.

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Section: Introductionmentioning

confidence: 99%

Correlation of Serum C-Reactive Protein with Disease Severity in Tuberculosis Patients

Shameem¹,

Fatima²,

Ahmad³

et al. 2012

OJRD

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show abstract

“…After the start of treatment, the number of bacilli in the sputum decreases rapidly and in more than 90% of cases sputum smears become negative for AFB at 3 months. Studies have also shown that the time to sputum sterilisation (indicated by sputum negativity at 2 or 3 months) is an important determinant of relapse (4–8). New risk factors for TB, such as human immunodeficiency virus (HIV) infection are challenging problems for TB control all over the world.…”

Section: Introductionmentioning

confidence: 99%

Factors influencing sputum smear and culture conversion time among patients with new case pulmonary tuberculosis

Güler

Ünsal

Dursun

et al. 2006

International Journal of Clinical Practice

111

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Sputum smear and culture conversion are important indicators for the effectiveness of treatment and the infectivity of the patient. The aim of this study was to identify the factors influencing both sputum smear and culture conversion time among patients with new case pulmonary tuberculosis (TB). The study was conducted in a reference hospital in Turkey in which 737 patients with pulmonary TB were hospitalised between January 2000 and 2005. We evaluated 306 (193 men and 113 women) human immunodeficiency virus-negative patients diagnosed with new case pulmonary TB. Factors associated with both sputum smear and culture conversion time (days) were investigated. Patients with diabetes mellitus (DM), cavitary disease, radiologically extensive disease had longer sputum smear and culture conversion time than the other groups. In addition, old age, male sex, smoking and thrombocytosis were found to be significantly associated with sputum smear conversion time. In the logistic regression analysis, the presence of DM and extensive disease were determined as independent factors associated with persistent sputum smear and culture positivity at the end of 2 months. The presence of DM and extensive disease were found to be independent risk factors influencing both sputum smear and culture conversion time in pulmonary TB. Sputum smear and culture examinations should be considered together to assess the poor prognosis.

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“…The appropriate treatment regimen should be started without waiting for culture results, if the clinical picture and cytology and/or histology are consistent with a diagnosis of TB 19 …”

Section: Discussionmentioning

confidence: 99%

“…A minority of TB cases show resistance to these antibiotics. In England, 6–8 per cent of cases are resistant to isoniazid, and 1 per cent of cases are resistant to more than one of the standard antituberculous antibiotics 19 . Multidrug-resistant TB is defined as TB caused by organisms that are resistant to isoniazid and rifampicin, two of the first-line drugs in TB treatment.…”

mentioning

confidence: 99%

Tuberculosis presenting as bilateral vocal fold palsy: case report and review of otolaryngological manifestations of tuberculosis

2011

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Short course chemotherapy for pulmonary tuberculosis

Cited by 8 publications

References 9 publications

Correlation of Serum C-Reactive Protein with Disease Severity in Tuberculosis Patients

Correlation of Serum C-Reactive Protein with Disease Severity in Tuberculosis Patients

Factors influencing sputum smear and culture conversion time among patients with new case pulmonary tuberculosis

Tuberculosis presenting as bilateral vocal fold palsy: case report and review of otolaryngological manifestations of tuberculosis

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