Correlation of Serum C-Reactive Protein with Disease Severity in Tuberculosis Patients

Shameem, Mohammad; Fatima, Nazish; Ahmad, Asrar; Malik, Abida; Husain, Qayyum

doi:10.4236/ojrd.2012.24014

Cited by 9 publications

(11 citation statements)

References 16 publications

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“…Similar results were reported in another study with CRP (14) , but the same was not observed for ESR marker. When CI variable and the smear were evaluated, CRP also showed a significant association (Table 3), as shown in published reports (6,22) , in which CRP levels were significantly higher in the most severe tuberculosis before starting treatment.…”

Section: Discussionsupporting

confidence: 57%

Markers of acute-phase response in the treatment of pulmonary tuberculosis

Martins¹,

Gama²,

Valcarenghi

et al. 2014

Jornal Brasileiro De Patologia E Medicina Laboratorial

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Section: Discussionsupporting

confidence: 57%

Markers of acute-phase response in the treatment of pulmonary tuberculosis

Martins¹,

Gama²,

Valcarenghi

et al. 2014

Jornal Brasileiro De Patologia E Medicina Laboratorial

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“…The difference in the CRP levels at the end of treatment was however statistically significant. Similar results were reported by Mohammad Shameemet al [12] , Peresi E et al [7] , Lee JH et al [13] and Plit ML [14] .…”

Section: Discussionsupporting

confidence: 89%

Study of the Serum Levels of C-Reactive Proteins as an Indicator of Disease Activity in Pulmonary Tuberculosis and Monitoring Response to Treatment

Sharma¹,

Sharma²,

Sharma³

et al. 2016

AIMDR

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Background: Pulmonary Tuberculosis is caused by mycobacterium tuberculosis. C-reactive proteins (CRP) are produced in the body by liver in response to inflammation caused by Mycobacterial infection. Insufficient information is available in medical literature, correlating serum CRP levels to the severity of pulmonary tuberculosis. The present study was undertaken to correlate the validity of serum CRP levels to clinical findings. Severity of pulmonary tuberculosis, need for ventilator support, response to anti-tubercular therapy and mortality. Objectives: To correlate the serum CRP levels with clinical findings, mortality, radiological severity and response to anti-tubercular treatment in patients suffering from pulmonary tuberculosis. Methods: The present study was conducted in 50 new sputum positive pulmonary TB patients and 50 healthy individuals. The patients were evaluated for clinical and radiological findings, which were correlated to baseline CRP levels. CRP levels were measured at 2 months and after completion of treatment and correlated to treatment end results. Results: Mean baseline CRP levels in pulmonary tuberculosis patients were 55.32mg/L (range 16-144mg/L).CRP levels among normal healthy individuals were 4.46 mg/L (range 2-8mg/L). CRP levels were significantly higher in TB patients with fever, tachycardia, tachypnea, hypotension, respiratory distress and the need for ventilatory support when compared to patients without these features. The study showed significant correlation between CRP levels and radiological extent of disease. Baseline CRP levels were significantly higher in mortality group when compared to survivor group.CRP levels showed progressive decline in patients who were cured. Conclusion: The CRP levels in pulmonary tuberculosis patients before initiating anti-tubercular therapy showed a positive correlation with features like presence of fever, tachycardia, tachypnea, hypotension, respiratory distress, need for ventilator support, radiological severity and in patients who died. Thus, serum CRP levels can be used as a surrogate marker for severity of pulmonary tuberculosis in the patients. This is probably the first study conducted in North India correlating CRP levels and disease severity of pulmonary Tuberculosis to the best of our knowledge.

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“…Study by Khalid et al [11] in pulmonary TB patients showed a similar pattern with raised overall mean CRP in patients with a mean of 9.87±4.83 in cases and serum CRP was 2.76±1.34 in controls (p 0.01). Shameem et al [12] in their study from north India found results comparable to our study. They found serum-CRP levels to be significantly higher at baseline (43.65 ± 23.68), as compared with the follow-up patients (9.88 ± 5.23).This study also studied changes in serum CRP concentration during treatment with regimen of antitubercular therapy.…”

Section: Discussionsupporting

confidence: 80%

Study of Inflammatory Markers in Sputum Positive Patients of Pulmonary Tuberculosis and its Response to Anti-tubercular Treatment

Dar¹

2018

jmscr

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Correlation of Serum C-Reactive Protein with Disease Severity in Tuberculosis Patients

Cited by 9 publications

References 16 publications

Markers of acute-phase response in the treatment of pulmonary tuberculosis

Markers of acute-phase response in the treatment of pulmonary tuberculosis

Study of the Serum Levels of C-Reactive Proteins as an Indicator of Disease Activity in Pulmonary Tuberculosis and Monitoring Response to Treatment

Study of Inflammatory Markers in Sputum Positive Patients of Pulmonary Tuberculosis and its Response to Anti-tubercular Treatment

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