SHORT COMMUNICATIONS: Interaction of Mouse Interferon and Platelet-Derived Growth Factor During Multiplication of BALB/c 3T3 Cells

Abstract

Mouse fibroblast-drived interferon (MuIFN) at concentrations of 0.1-0.001 U/ml enhanced the multiplication of BALB/c 3T3 cells. Experiments with the cells cultured in 5% platelet poor plasma serum (PPPS) medium in which the cells not multiply without platelet derived growth factor (PDGF), suggested that there is a positive cooperativity between small amounts of MuIFN and submitogenic doses of PDGF. The growth-promoting activity of 10,000-1,000 U/ml detected in the partially purified MuIFN from C243 cells assayed in 5% PPPS medium was probably the result of the contamination of MuIFN preparations with a PDGF-like growth factor.

Interactions of interferons and transforming growth factors during clonal growth of mouse or human cells in soft agar and in mice

“…The effects we describe are not limited to TGFs. Antagonistic interactions between IFNs and platelet-derived growth factor (I'DGF) as well as other GFs have been described (Inglot c't nl., 1980;Oleszak and Inglot, 1980;Inglot and Albin, 1983;Inglot and Pajtasz, 1986). The ability of various protein and non-protein growth-stimulating factors to reverse the antiproliferative activity of interferons has also been investigated in detail (Ebsworth et n / .…”

“…Antagonistic interactions between IFNs and platelet-derived growth factor (I'DGF) as well as other GFs have been described (Inglot c't nl., 1980;Oleszak and Inglot, 1980;Inglot and Albin, 1983;Inglot and Pajtasz, 1986). Antagonistic interactions between IFNs and platelet-derived growth factor (I'DGF) as well as other GFs have been described (Inglot c't nl., 1980;Oleszak and Inglot, 1980;Inglot and Albin, 1983;Inglot and Pajtasz, 1986).…”