Short communication: The effect of delayed colostrum feeding on plasma concentrations of glucagon-like peptide 1 and 2 in newborn calves

Inabu, Y.; Fischer, Albert J.; Song, Yang; Guan, Le Luo; Oba, M.; Steele, M.A.; Sugino, Toshihisa

doi:10.3168/jds.2018-14412

Cited by 19 publications

(21 citation statements)

References 27 publications

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“…It was reported that circulating level of GLP‐2 was increased approximately 2 hr after nutrient ingestion as a result of nutrients arriving in the distal intestine (Connor, Evock‐Clover, Walker, Elsasser, & Kahl, ). In addition, our previous study reported that rise in plasma GLP‐2 concentration was observed within 6 hr after feeding in neonatal calves (Inabu et al, ). In the current study, all blood samples were collected 4 hr after MR feeding, and no treatment effect was observed for plasma GLP‐2 concentration after weaning period (at 63, 70, and 77 days after birth; data not shown), thus greater plasma GLP‐2 concentration for TB calves until weaning should be attributed to treatment effect.…”

Section: Resultsmentioning

confidence: 91%

“…A treatment effect was observed for plasma GLP‐2 concentration ( p = 0.02): mean plasma concentration of GLP‐2 among whole period was significantly higher for TB (0.60 ± 0.05 ng/ml) compared with CON (0.41 ± 0.05 ng/ml). In our previous studies, it was indicated that plasma GLP‐2 concentration was affected by feeding method of first colostrum (Inabu et al, , ). As described above, feeding method of colostrum feeding is similar among dairies and serum total protein concentration and albumin‐globulin ratio did not differ between treatment groups, thus, greater GLP‐2 concentration for TB from 7 days after birth may not be due to difference in feeding method of colostrum.…”

Section: Resultsmentioning

confidence: 98%

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The effect of tributyrin supplementation to milk replacer on plasma glucagon‐like peptide 2 concentrations in pre‐weaning calves

Inabu

Murayama

Inouchi

et al. 2019

Animal Science Journal

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The objective of this study was to evaluate the effect of tributyrin (TB) supplementation to milk replacer (MR) on performance, health, and blood concentrations of metabolite and glucagon‐like peptide (GLP‐2) in pre‐weaning calves. Twenty Holstein heifer calves were raised on an intensified nursing program using MR supplemented with either palm oil (CON) or TB (TB) at 0.3% (as fed basis) for 7 weeks starting 1 week after birth. Calves were fed a calf starter and kleingrass from the beginning of the study. Blood samples were obtained weekly to measure blood glucose, serum β‐hydroxybutyric acid (BHBA), insulin‐like growth factor 1 (IGF‐1), and plasma GLP‐2 concentrations. Starter DMI and metabolizable energy (ME) intake were lower in TB calves at 46, 47, from 49 to 55 days after birth compared with the CON calves. However, any growth parameters were not affected by TB treatment. Blood glucose, serum BHBA, and IGF‐1 concentrations were not affected by TB supplementation. On the other hand, mean plasma GLP‐2 concentration among whole experimental period was higher for TB (0.60 ng/ml) compared with CON (0.41 ng/ml). In conclusion, feeding MR supplemented with TB increases plasma GLP‐2 concentration, which might counterbalance the growth performance of TB calves despite the decreased ME intake.

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Section: Resultsmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 98%

The effect of tributyrin supplementation to milk replacer on plasma glucagon‐like peptide 2 concentrations in pre‐weaning calves

Inabu

Murayama

Inouchi

et al. 2019

Animal Science Journal

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“…Hammon et al (2013) reported that ingested colostrum enhanced glucose uptake via the improved absorptive capacity of the GIT. In addition, it has been reported that colostrum intake increased plasma concentration of insulin, which is involved in glucose homeostasis (Hammon et al, 2000;Inabu et al, 2018). In the previous study, amount, timing, and frequency of colostrum intake affected insulin secretion in calves (Hadorn et al, 1997;Hammon and Blum, 1998).…”

Section: Introductionmentioning

confidence: 83%

“…Glucagon-like peptide-1 (GLP-1) is a gut-derived peptide secreted from intestinal L-cells in response to nutrient absorption from the intestine (Connor et al, 2015;Inabu et al, 2017Inabu et al, , 2018. Glucagon-like peptide-1 is involved in glucose homeostasis via the stimulation of insulin secretion in both nonruminants (O'Halloran et al, 1990;Holz et al, 1993) and ruminants (Faulkner, 1991;Edwards et al, 1997;Fukumori et al, 2012) as well as its own direct action without mediating insulin action (Luque et al, 2002;Acitores et al, 2005;Sancho et al, 2005Sancho et al, , 2006.…”

Section: Introductionmentioning

confidence: 99%

Effect of extended colostrum feeding on plasma glucagon-like peptide-1 concentration in newborn calves

Inabu

Pyo

Pletts

et al. 2019

Journal of Dairy Science

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Glucagon-like peptide-1 (GLP-1) plays a role in the regulation of glucose homeostasis via the stimulation of insulin secretion. The objective of this study was to evaluate the effect of extended colostrum feeding on plasma concentration of GLP-1. Holstein bull calves (n = 27) were fed pooled colostrum at 7.5% of birth body weight at 2 h after birth and then fed mature milk (M), a 50:50 mixture of pooled colostrum and milk (CM), or pooled colostrum (C; n = 9 for each treatment) at 5% of birth body weight at 12 h after birth and every 12 h thereafter until 72 h after birth. Blood samples were obtained before (1 and 2 h after birth) and after (until 72 h after birth; 42 time points) the first colostrum feeding, and plasma concentrations of glucose, insulin, and GLP-1 were measured. Data were analyzed by ANOVA of JMP 13 (SAS Institute Inc., Cary, NC) with treatment, time, and treatment × time interaction as fixed effects. Treatment × time interaction was observed for plasma insulin and glucose concentrations, which were mainly the result of lower concentrations from 1 to 2 d after birth for C compared with M. Conversely, on d 3 after birth, the difference between treatments was not observed for insulin and glucose. For the entire experimental period, plasma GLP-1 concentration was higher for C (2.25 ng/mL) compared with M (1.41 ng/mL) and tended to be higher compared with CM (1.58 ng/ mL). A treatment × time interaction was observed for GLP-1, but unlike glucose and insulin, this was mainly the result of higher concentrations from 54 to 72 h after birth (on d 3 after birth) for C compared with M or CM. Postprandial plasma concentration of glucose was not correlated with that of GLP-1 but was positively correlated with that of insulin for the 4-h period after feeding on d 1 (r = 0.30) and d 3 after birth (r = 0.33). Postprandial plasma concentration of GLP-1 was positively correlated with that of insulin for the 4-h period after feeding on d 3 after birth (r = 0.20). These results indicate that extended colostrum feeding may increase plasma GLP-1 concentrations, especially 3 d after birth, but further study is necessary to determine the effect on plasma insulin and glucose concentrations.

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“…In addition to containing bioactive molecules, the consumption of colostrum also stimulates endogenous production of beneficial hormones that assist in the maturation of the GIT. For instance, Inabu et al (2018) demonstrated that plasma glucagon-like peptide-1 and -2 concentrations increase after colostrum feeding and that glucagon-like peptide-1 concentration was lower for calves not fed colostrum until 12 h of life compared with calves fed immediately after birth. As glucagon-like peptide-1 and -2 play a key role in glucose homeostasis (Fukumori et al, 2012) and stimulating gastrointestinal growth (Taylor-Edwards et al, 2011), respectively, it is clear that the feeding of colostrum has beneficial effects on gut development and furthers our understanding on the role of gut-derived peptides and their potential implications for the improvement of calf health and performance (Inabu et al, 2018).…”

Section: Colostrum Feedingmentioning

confidence: 99%

Invited Review: Nutritional regulation of gut function in dairy calves: From colostrum to weaning

Fischer

Villot

Niekerk

et al. 2019

Applied Animal Science

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publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. ABSTRACTPurpose: Published literature regarding calf nutrition was reviewed to create an information base for the implementation of proper nutritional management to maximize health and productivity.Sources: The main source of data and information for this review was peer-reviewed literature.Synthesis: Feeding a sufficient volume of colostrum during the first hours of life is crucial to calf health and survival; however, less is known about transition milk feeding and the potential benefits of the myriad of bioactive compounds it contains. After feeding colostrum and transition milk, calves are susceptible to diarrhea when moved onto high amounts of milk, and antibiotic use is often necessary to decrease disease. Feeding an elevated plane of milk nutrition results in increased ADG and, in some studies, increased future milk production. Thus, this nutritional strategy is recommended; however, weaning calves from high volumes of milk represents massive changes in the structure and microbiology of the gastrointestinal tract.Conclusions and Applications: Colostrum and transition milk contain an abundance of bioactive molecules that can positively affect gut development and microbiota. There is significant potential for the use of novel feeding strategies and microbial-based products as alternatives to antibiotics. Calves fed an elevated plane of nutrition in the first month of life have greater productivity and growth. However, weaning should take place later in life. Moreover, applying a proper step-down feeding protocol is recommended, as it allows calves to intake and digest sufficient solid feed for growth and minimize distress at weaning.

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Short communication: The effect of delayed colostrum feeding on plasma concentrations of glucagon-like peptide 1 and 2 in newborn calves

Cited by 19 publications

References 27 publications

The effect of tributyrin supplementation to milk replacer on plasma glucagon‐like peptide 2 concentrations in pre‐weaning calves

The effect of tributyrin supplementation to milk replacer on plasma glucagon‐like peptide 2 concentrations in pre‐weaning calves

Effect of extended colostrum feeding on plasma glucagon-like peptide-1 concentration in newborn calves

Invited Review: Nutritional regulation of gut function in dairy calves: From colostrum to weaning

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