Short communication: Risk of subacute ruminal acidosis affects the feed sorting behavior and milk production of early lactation cows

Coon, R.E.; Duffield, T.F.; DeVries, T.J.

doi:10.3168/jds.2018-15064

Cited by 18 publications

(9 citation statements)

References 28 publications

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“…SARA is one of the most important metabolic disorders in ruminant production, which has a certain negative impact on rumen fermentation, animal welfare, productivity and farm profitability [30][31][32]. At present, time for pH below optimal level is used as a critical indicator to determine the severity of SARA.…”

Section: Discussionmentioning

confidence: 99%

Effects of subacute ruminal acidosis on colon epithelial morphological structure, permeability and expression of key tight junction proteins in a dairy goat model

wang

Min

et al. 2020

Preprint

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Background: The hindgut epithelial barrier plays an important role in maintaining absorption and immune homeosrasis in ruminants. However, there is little information available on changes of colon epithelial barrier structure and function following grain-induced subacute ruminal acidosis (SARA). The objective of this study was to investigate the effects of SARA on colon epithelial morphological structure, permeability and gene expression involved in epithelial barrier function using dairy goats as a ruminant model. Methods: Twelve mid-lactating Sannan dairy goats (62.13 ± 4.76 kg) were randomly divided into either control (n = 6) or SARA treatment (n = 6). Control goats were fed a mixed diet (non-fiber carbohydrates/neutral detergent fiber (NFC/NDF) =1.15) for 60 days, SARA induction goats were given 4 mixed diets with NFC to NDF ratios of 1.15, 1.49, 2.12 and 2.66 to induce development of SARA. The duration of each diet was 15 d including 12 d for adaption and 3 d for sampling. Continuous ruminal pH recordings were utilized to diagnose the severity of SARA. Additionally, Plasma and colonic tissue were collected to evaluate the epithelial tissue morphological structure, permeability and expression of tight junction (TJ) protein using histological techniques, Ussing chamber, real-time PCR and western blotting. Results: Profound disruption in the colonic epithelium was mainly manifested as the electron density of TJ decreased, intercellular space widened and mitochondria swelled in SARA dairy goats. Epithelial Isc, Gt and the mucosal-to-serosal flux of FD4 ( P < 0.05) were increased, PD was decreased in SARA dairy goats compared with the control. SARA increased the plasma LPS ( P < 0.001), D-lactic acid contents ( P = 0.025) and DAO activity ( P = 0.003). Increased gene and protein expression of claudin-1 and occludin ( P < 0.05) were observed in colonic epithelium of SARA goats. Conclusion: Overall, the data of present study demonstrate that SARA can impair the barrier function of the colonic epithelium in dairy goats, which is associated with severe epithelial structural damage and increased permeability and changes in the expression of TJ proteins.

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Section: Discussionmentioning

confidence: 99%

Effects of subacute ruminal acidosis on colon epithelial morphological structure, permeability and expression of key tight junction proteins in a dairy goat model

wang

Min

et al. 2020

Preprint

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“…Presumably, the observed relationships will not only be attributable to the composition of the diet but can also be related to the individual feed intake behavior of the animals. In this respect, Coon et al (2019) demonstrated that part of the observed interanimal variance regarding susceptibility to SARA is attributable to behavioral differences in sorting against long particles.…”

Section: Associations Of the Srs With Other Traits And Feed Datamentioning

confidence: 97%

Development of a subacute ruminal acidosis risk score and its prediction using milk mid-infrared spectra in early-lactation cows

Mensching

Zschiesche

Hummel

et al. 2021

Journal of Dairy Science

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A routine monitoring for SARA on the individual level could support the minimization of economic losses and the ensuring of animal welfare in dairy cows. The objectives of this study were (1) to develop a SARA risk score (SRS) by combining information from different data acquisition systems to generate an integrative indicator trait, (2) the investigation of associations of the SRS with feed analysis data, blood characteristics, performance data, and milk composition, including the fatty acid (FA) profile, (3) the development of a milk mid-infrared (MIR) spectra-based prediction equation for this novel reference trait SRS, and (4) its application to an external data set consisting of MIR data of test day records to investigate the association between the MIR-based predictions of the SRS and the milk FA profile. The primary data set, which was used for the objectives (1) to (3), consisted of data collected from 10 commercial farms with a total of 100 Holstein cows in early lactation. The data comprised barn climate parameters, pH and temperature logging from intrareticular measurement boluses, as well as jaw movement and locomotion behavior recordings of noseband-sensor halters and pedometers. Further sampling and data collection included feed samples, blood samples, milk performance, and milk samples, whereof the latter were used to get the milk MIR spectra and to estimate the main milk components, the milk FA profile, and the lactoferrin content. Because all measurements were characterized by different temporal resolutions, the data preparation consisted of an aggregation into values on a daily basis and merging it into one data set. For the development of the SRS, a total of 7 traits were selected, which were derived from measurements of pH and temperature in the reticulum, chewing behavior, and milk yield. After adjustment for fixed effects and standardization, these 7 traits were combined into the SRS using a linear combination and directional weights based on current knowledge derived from literature studies. The secondary data set was used for objective (4) and consisted of test day records of the entire herds, including performance data, milk MIR spectra and MIR-predicted FA. At farm level, it could be shown that diets with higher proportions of concentrated feed resulted in both lower daily mean pH and higher SRS values. On the individual level, an increased SRS could be associated with a modified FA profile (e.g., lower levels of short-and medium-chain FA, higher levels of C17:0, odd-and branched-chain FA). Furthermore, a milk MIR-based partial least squares regression model with a moderate predictability was established for the SRS. This work provides the basis for the development of routine SARA monitoring and demonstrates the high potential of milk composition-based assessment of the health status of lactating cows.

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“…The fact that the behavior of the animal is directly reflected in the pH is also in line with the results of Macmillan et al (2017), who found that cows classified as having a higher risk for SARA ingested feed less evenly during the day than did low-risk cows. Cows at lower and higher SARA risk also differ in sorting behavior (Coon et al, 2019): low-risk cows sorted less feed and thus ate a more balanced diet than did high-risk cows.…”

Section: Modeling Of Reticular and Ventral Ruminal Ph Progressionsmentioning

confidence: 99%

Modeling reticular and ventral ruminal pH of lactating dairy cows using ingestion and rumination behavior

Mensching

Bünemann

Meyer

et al. 2020

Journal of Dairy Science

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Short communication: Risk of subacute ruminal acidosis affects the feed sorting behavior and milk production of early lactation cows

Cited by 18 publications

References 28 publications

Effects of subacute ruminal acidosis on colon epithelial morphological structure, permeability and expression of key tight junction proteins in a dairy goat model

Effects of subacute ruminal acidosis on colon epithelial morphological structure, permeability and expression of key tight junction proteins in a dairy goat model

Development of a subacute ruminal acidosis risk score and its prediction using milk mid-infrared spectra in early-lactation cows

Modeling reticular and ventral ruminal pH of lactating dairy cows using ingestion and rumination behavior

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