Short communication: Minimum bactericidal concentration of disinfectants evaluated for bovine digital dermatitis-associated Treponema phagedenis-like spirochetes

Hartshorn, R.; Thomas, Evangelos; Anklam, Kelly; Lopez-Benavides, M.; Buchalova, M.; Hemling, T. C.; Döpfer, Dörte

doi:10.3168/jds.2012-5994

Cited by 27 publications

(28 citation statements)

References 20 publications

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“…The level of contamination reported here is relatively low compared with levels used to test disinfectant activity (Hartshorn and others 2013), and therefore, it may not adversely affect biocide activity at concentrations typically used on farm. Furthermore, the relatively small herd size and the use of one farm means that further work is needed to generalise to large herd scenarios.…”

mentioning

confidence: 85%

Effect of a prewash on footbath contamination: a randomised control trial

et al. 2017

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mentioning

confidence: 85%

Effect of a prewash on footbath contamination: a randomised control trial

et al. 2017

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“…The antibacterial properties of copper have been known for a very long time, the first reports of using copper against several diseases being more than 3,000 yr old (Konieczny and Rdzawski, 2012). Hartshorn et al (2013) demonstrated an in vitro effect of copper sulfate against a Treponema phagedenis-like isolate. They also found that the effectiveness of copper sulfate was severely hampered when manure was present.…”

Section: Short Communicationmentioning

confidence: 98%

Short communication: Efficacy of copper sulfate hoof baths against digital dermatitis—Where is the evidence?

Thomsen

2015

Journal of Dairy Science

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Digital dermatitis is a major problem in modern dairy production because of decreased animal welfare and financial losses. Individual cow treatments are often seen as too time consuming by farmers, and walk-through hoof baths have therefore been used extensively to control digital dermatitis. For decades, copper sulfate hoof baths have been used to treat and prevent digital dermatitis. Copper sulfate has been referred to as the industry gold standard when it comes to hoof-bath chemicals. In several scientific studies testing the efficacy of other hoof-care products, copper sulfate has been used as a positive control, thereby indicating that copper sulfate has a known positive effect. However, this may not be the case. A dilemma may exist between (1) copper sulfate generally being perceived as being effective against digital dermatitis and (2) a possible lack of well-documented scientific evidence of this effect. The objective of this study was to evaluate the existing scientific literature to determine whether the efficacy of copper sulfate used in hoof baths against digital dermatitis has in fact been demonstrated scientifically. A systematic literature search identified 7 peer-reviewed journal articles describing the efficacy of copper sulfate in hoof baths as treatment or prevention of bovine digital dermatitis. Only 2 of the 7 studies compared copper sulfate to a negative control; most studies were relatively small, and often no clear positive effect of copper sulfate was demonstrated. In conclusion, the frequent claim that copper sulfate is widely reported to be effective is supported by little scientific evidence. Well-designed clinical trials evaluating the effect of copper sulfate against digital dermatitis compared with a negative control are needed. Until such studies have been made, the efficacy of copper sulfate in hoof baths against digital dermatitis remains largely unproven.

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“…The aim of this study was the in vitro determination of the MIC and MBC of Thymox (Laboratoire M2, Sherbrooke, Québec, Canada) for a selection of microorganisms related to infectious bovine foot diseases using a broth dilution method similar to that described by Hartshorn et al (2013). A secondary aim was to compare the in vitro efficacy of copper sulfate (a commonly used antibacterial agent in the industry) and Thymox against the same selected microorganisms.…”

Section: Short Communicationmentioning

confidence: 99%

“…Using a broth dilution method similar to that described by Hartshorn et al (2013), the in vitro MIC and MBC values for Thymox and copper sulfate were established. Thymox is a broad-spectrum agricultural disinfectant with a footbath indication.…”

Section: Short Communicationmentioning

confidence: 99%

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Short communication: Determination of the ability of Thymox to kill or inhibit various species of microorganisms associated with infectious causes of bovine lameness in vitro

Kulow

Zibaee

Allard³

et al. 2015

Journal of Dairy Science

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Infectious claw diseases continue to plague cattle in intensively managed husbandry systems. Poor foot hygiene and constant moist environments lead to the infection and spread of diseases such as digital dermatitis (hairy heel warts), interdigital dermatitis, and interdigital phlegmon (foot rot). Currently, copper sulfate and formalin are the most widely used disinfecting agents in bovine footbaths; however, the industry could benefit from more environmentally and worker friendly substitutes. This study determined the in vitro minimum inhibitory concentrations and minimum bactericidal concentrations of Thymox (Laboratoire M2, Sherbrooke, Québec, Canada) for a selection of microorganisms related to infectious bovine foot diseases. Thymox is a broad-spectrum agricultural disinfectant that is nontoxic, noncorrosive, and readily biodegradable. The values for minimum inhibitory concentration and minimum bactericidal concentration indicated that Thymox inhibited growth and killed the various species of microorganisms under study at much lower concentrations compared with the recommended working concentration of a 1% solution. Overall, the values found in this study of minimum inhibitory concentration and minimum bactericidal concentration of Thymox show its potential as an alternative antibacterial agent used in bovine footbaths; however, field trials are needed to determine its effectiveness for the control and prevention of infectious claw diseases.

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Short communication: Minimum bactericidal concentration of disinfectants evaluated for bovine digital dermatitis-associated Treponema phagedenis-like spirochetes

Cited by 27 publications

References 20 publications

Effect of a prewash on footbath contamination: a randomised control trial

Effect of a prewash on footbath contamination: a randomised control trial

Short communication: Efficacy of copper sulfate hoof baths against digital dermatitis—Where is the evidence?

Short communication: Determination of the ability of Thymox to kill or inhibit various species of microorganisms associated with infectious causes of bovine lameness in vitro

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