Short Communication Association of ATP1A1 gene polymorphism with heat tolerance traits in dairy cattle

Liu, Y X; Zhou, Xiaoping; Li, D Q; Cui, Qun-Wei; Wang, G L

doi:10.4238/vol9-2gmr769

Cited by 36 publications

(37 citation statements)

References 14 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mutations in the intron region of the IGF2 gene are closely related to muscle and fat deposit (Knoll et al, 2000;Liu et al, 2003). Liu et al (2010) found a C to T variation in intron 14 of the bovine ATP1A1 gene, and they also found significant correlations between the ATP1A1 gene polymorphism and the coefficient of heat tolerance. In this study, we found that all four SNPs in the bovine Insig-1 gene exist in the intron region, which may affect the economic traits by affecting the translation efficiency of Insig-1 itself.…”

Section: Discussionmentioning

confidence: 85%

Four SNPs of insulin-induced gene 1 associated with growth and carcass traits in Qinchuan cattle in China

Liu¹,

Liu²,

He³

et al. 2012

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. The insulin-induced gene 1 (Insig-1) is a regulator of lipid metabolism and plays an important role in the sterol-mediated regulation of SREBP, SCAP and HMG-CoA reductase. We used PCR-RFLP and DNA sequencing to detect polymorphisms of the Insig-1 gene in 215 individuals of the Qinchuan cattle breed. Four SNPs [4366(A>G), 4534(T>C), 5001(T>C), and 5235(G>A)] were indentified. The association of the genetic viariation with growth and carcass traits (body length, withers height, hip width, slaughter weight, and carcass weight) was analyzed. The individuals with better performance had the GG genotype at locus A4366G, and CC genotypes at locus T4534C and locus T5001C. These could be used for beef cattle breeding improvement in China. Additionally, linkage disequilibrium analysis reflected that all mutations were in low linkage disequilibrium with each other. We concluded that polymorphisms in the Insig-1 gene are associated with growth and carcass traits and could be used for marker-assisted selection and management in beef cattle breeding programs.

show abstract

Section: Discussionmentioning

confidence: 85%

Four SNPs of insulin-induced gene 1 associated with growth and carcass traits in Qinchuan cattle in China

Liu¹,

Liu²,

He³

et al. 2012

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…The least-squares mean of each genotype was estimated, and differences between genotypes were analyzed using the Bonferroni test (Schenkel et al 2006). The model (Liu et al 2010) was: Y ĳ = μ + G i + e ĳ , where Y ij are the observed values of different egg traits, μ is the population mean, G i are the effects of individual genotypes, and e ĳ is the effect of random error.…”

Section: Statistical and Association Analysismentioning

confidence: 99%

Investigation of insulin-like growth factor-1 gene with egg-laying traits in the Muscovy duck (Cairina moschata)

Liu

Lan

et al. 2016

Can. J. Anim. Sci.

View full text Add to dashboard Cite

Muscovy duck (Cairina moschata) is characterized by broodiness, and egg-laying traits in this species should be of primary concern. As a member of the IGF superfamily of proteins, insulin-like growth factor-1 (IGF-1) is an important positive regulator of growth and gonad development in vertebrates. To explore the effect of IGF-1 on the growth hormone/insulin-like growth factors (GH/IGF) axis, we cloned and characterized IGF-1 of Muscovy duck. The expression level of IGF-1 was widely expressed in all the tested tissues, and the highest level was detected in the liver. In laying ducks, IGF-1 expression levels in the hypothalamus, pituitary, and ovary were very significantly higher (P < 0.01) than that in the tissues of nesting duck, and IGF-1 expression levels in the heart and liver were significantly higher (P < 0.05) than that in nesting duck tissues. Furthermore, a single nucleotide polymorphism (SNP) (A/G) was found and significantly (P < 0.05) associated with age at first egg and egg number at 300 d. This study provides the first evidence that IGF-1 promote egg-laying traits of Muscovy duck through two axes, involving GH/IGF and hypothalamic-pituitary-gonadal axes. These findings enrich the information of IGF-1 of Muscovy duck and demonstrate for the first time the ability of IGF-1 to promote reproduction, indicating that IGF-1 could be used as an important marker gene.

show abstract

“…Slick-haired crossbred calves of Carora (Brown Swiss 3 Venezuelan Criollo breed) and Holstein had lower RT compared with normal-haired contemporaries (0.188C to 0.48C). Liu et al (2010) investigated an ATP1A1 gene polymorphism in six genotypes. The heterozygous AC genotype showed the highest heat tolerance coefficient and lowest respiration rate, and therefore was the most favourable at the ATP1A1-P14 locus for the anti-heat stress trait in the population.…”

Section: Effects Of Hyperthermia On Dna Integrity and Embryonic Develmentioning

confidence: 99%

Future consequences and challenges for dairy cow production systems arising from climate change in Central Europe – a review

Gauly

Bollwein

Breves

et al. 2013

Animal

142

View full text Add to dashboard Cite

It is well documented that global warming is unequivocal. Dairy production systems are considered as important sources of greenhouse gas emissions; however, little is known about the sensitivity and vulnerability of these production systems themselves to climate warming. This review brings different aspects of dairy cow production in Central Europe into focus, with a holistic approach to emphasize potential future consequences and challenges arising from climate change. With the current understanding of the effects of climate change, it is expected that yield of forage per hectare will be influenced positively, whereas quality will mainly depend on water availability and soil characteristics. Thus, the botanical composition of future grassland should include species that are able to withstand the changing conditions (e.g. lucerne and bird's foot trefoil). Changes in nutrient concentration of forage plants, elevated heat loads and altered feeding patterns of animals may influence rumen physiology. Several promising nutritional strategies are available to lower potential negative impacts of climate change on dairy cow nutrition and performance. Adjustment of feeding and drinking regimes, diet composition and additive supplementation can contribute to the maintenance of adequate dairy cow nutrition and performance. Provision of adequate shade and cooling will reduce the direct effects of heat stress. As estimated genetic parameters are promising, heat stress tolerance as a functional trait may be included into breeding programmes. Indirect effects of global warming on the health and welfare of animals seem to be more complicated and thus are less predictable. As the epidemiology of certain gastrointestinal nematodes and liver fluke is favourably influenced by increased temperature and humidity, relations between climate change and disease dynamics should be followed closely. Under current conditions, climate change associated economic impacts are estimated to be neutral if some form of adaptation is integrated. Therefore, it is essential to establish and adopt mitigation strategies covering available tools from management, nutrition, health and plant and animal breeding to cope with the future consequences of climate change on dairy farming.Keywords: global warming, cow comfort, heat stress, heat tolerance, functional traits ImplicationsAs a consequence of global warming, drier and hotter summers are expected for Central Europe. Here we discuss multiple interactions between climate change and dairy production in Central Europe in its full complexity, starting from fodder resources to breeding impacts and farm economy. Under current conditions, the impact of climate change on the farm economy is estimated to be neutral if some form of adaptation is integrated. Thus, establishing mitigation and adaptation strategies covering available tools from management, nutrition, health and plant and animal breeding to cope with the future consequences of climate change on dairy farming are essential.-E-mail: Mgauly@gwdg.de 843 ...

show abstract

Short Communication Association of ATP1A1 gene polymorphism with heat tolerance traits in dairy cattle

Cited by 36 publications

References 14 publications

Four SNPs of insulin-induced gene 1 associated with growth and carcass traits in Qinchuan cattle in China

Four SNPs of insulin-induced gene 1 associated with growth and carcass traits in Qinchuan cattle in China

Investigation of insulin-like growth factor-1 gene with egg-laying traits in the Muscovy duck (Cairina moschata)

Future consequences and challenges for dairy cow production systems arising from climate change in Central Europe – a review

Contact Info

Product

Resources

About