Short-chain PEG molecules strongly bound to magnetic nanoparticle for MRI long circulating agents

Long circulating micelles of an amphiphilic random copolymer bearing cell outer membrane phosphorylcholine zwitterions

“…By providing a hydration layer and steric barrier surrounding the polymeric core, PEG coating can reduce non-specific binding of serum proteins to the particles, thereby reducing their clearance by MPS cells [9]. The stealth properties can be achieved and optimized by grafting a high density of PEG with MW ranging from 2k to 10k [3,[10][11][12][13]. Although PEGylation has been extensively studied on a variety of nanoparticle systems to increase surface hydrophilicity and improve circulation half-life by decreasing interactions with blood proteins and MPS cells [14][15][16][17], detailed investigations also recognize its disadvantages [18][19][20][21][22].…”

Highly magnetic Fe2O3 nanoparticles synthesized by laser pyrolysis used for biological and heat transfer applications

“…For medical and heat transfer applications, dispersions of superparamagnetic MNPs, containing stabilized assemblies with approximately 100 nm diameter is desirable [5]. A strong link (such as a covalent bonding) between the particle surface and its stabilizing anchor is preferred especially for nanoparticles suspended in biological fluids [6]. However, smaller organic molecules are preferred over longer polymers, especially for maximizing the magnetic fraction in the final aggregate.…”

Featured Article: Nanoenhanced matrix metalloproteinase-responsive delivery vehicles for disease resolution and imaging

“…40,41 Circulation time and organ accumulation of magnetite nanoparticles is similarly affected by encapsulation. 42 Results like these underline the importance of finding new ways of delivering drugs. Furthermore, encapsulation has the ability to impact the possible routes of delivery.…”