Short- but not long-lasting treadmill running reduces allodynia and improves functional recovery after peripheral nerve injury

Activity dependent therapies modulate the spinal changes that motoneurons suffer after a peripheral nerve injury

“…The same protocol that we used was able to reduce microglia activation after chronic constriction injury in mice (Cobianchi et al, 2010). In agreement with this, we observed a significant reduction in microglia processes around motoneurons already at one week.…”

“…Moreover, activity-dependent therapies can also modulate the plastic changes observed after peripheral nerve injury, as reported for the modulation of the H reflex (Asensio-Pinilla et al, 2009;Udina et al, 2011a;Vivó et al, 2008) and of pain responses (Cobianchi et al, 2010(Cobianchi et al, , 2013. Since synaptic stripping might be a source of poor functional recovery following peripheral nerve injury, these combined effects of treadmill training have the potential for improved functional recovery after injury.…”

Efeito da associação da laserterapia com a natação no reparo morfológico do nervo isquiático e na recuperação funcional de ratos submetidos à axonotmese

“…Several experiments involving denervated animals 18 have described exercise as the factor that provides the most budding and extension of the axons, 12 the greatest increase in the number of myelinated fibers 13,14 and the best improvement in functional recovery for the injured member 15 . The results from this study are similar to those found in the literature regarding evaluating functional recovery, due to the fact that the groups that performed exercise showed better results compared to groups who did not go through the swimming protocol.…”

“…Several authors have shown beneficial results by using exercise, namely through greater budding and extension of the axons 12 , increased number of myelinated nerve fibers, 13,14 and improved functional recovery of the injured member [15][16][17] . There have been extensive discussions in the scientific community 18 regarding recommendations as per the type of exercise as well as its duration and intensity.…”

Physical rehabilitation to treat neuropathic pain

“…In summary, results of animal model studies propose this effect of exercise by increased neurotrophin levels, neural activity recoding, peripheral sensory reorganization, supraspinal neuronal excitability change and cortical sensory projections 58 . For example, a study by Cobianchi et al 59 has compared two treadmill running protocols in mice after chronic sciatic nerve constriction injury. Brief protocol of exercises (1h per day in the 5 days following experimental nervous injury) has decreased NP symptoms (decreased allodynia, decreased microglia and astrocytes expression).…”