Short-Arm Deletions in G-Group Chromosomes

A 45,XX,21--child: attempt at a cytological and clinical interpretation of the karyotype.

“…21 is the only chromosome compatible with life and development in the trisomic state. Furthermore, deficiencies of the chromosomes in group G are of three categories: deletions associated with congenital abnormalities (Weleber, Hecht, and Giblett, 1968;Ricci, Dallapiccola, and Preto, 1970;Warren and Rimoin, 1970), monosomy for one cell line likewise associated with a variation of abnormalities (Lejeune et al, 1964;Reisman et al, 1966;Bauchinger, Schmid, and R6ttinger, 1968;Challacombe and Taylor, 1969;Endo et al, 1969;Zdansky et al, 1969), and, finally, deletions without any clinical signs (Migeon, 1965;Neu, Leao, and Gardner, 1966). In the various cases with abnormalities the clinical picture shows considerable variation.…”

A Familial Transmission of Heterozygous No. 17 Chromosomes in Relation to Spontaneous Abortion

“…However, it is problem that the partial long arm deletion of a no. 17 chromosome is essentially associated with a particular disease, since reported cases with a short arm deletion of a G chromosome were associated with different diseases (Shaw 1962, Neu et al 1966, Ito and Makino 1966.…”

A Preliminary Note on a Case of Trisomic Down's Syndrome with a Short Arm Deletion of a G Group (21-22) Chromosome

“…Evidence of a short arm deletion in the G group chromosomes has recently been presented by several authors (Gunz et al 1962, Shaw 1962, Migeon 1965, Subrt and Brychnac 1966, Neu et al 1966. It is a general feature that this aberration is not associated with any particular disease.…”

“…Neu et al, (1966) reviewed the literature and concluded that the short arm deleted chromosome would be a familial autosomal variant because it was not associated with any particular disease.…”